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Norsalsolinol hydrobromide

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Identification
Molecular formula
C16H18BrNO4
CAS number
63642-59-7
IUPAC name
1-[(3,4-dihydroxyphenyl)methyl]-1,2,3,4-tetrahydroisoquinolin-2-ium-6,7-diol;bromide
State
State

At room temperature, Norsalsolinol hydrobromide is typically in a solid state. It is a crystalline powder and is stable under normal conditions of storage.

Melting point (Celsius)
238.00
Melting point (Kelvin)
511.00
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
350.18g/mol
Molar mass
350.1790g/mol
Density
1.6000g/cm3
Appearence

Norsalsolinol hydrobromide appears as a white to off-white crystalline powder. It is hygroscopic and soluble in water, forming clear solutions.

Comment on solubility

Solubility of 1-[(3,4-dihydroxyphenyl)methyl]-1,2,3,4-tetrahydroisoquinolin-2-ium-6,7-diol; bromide

The solubility of the compound 1-[(3,4-dihydroxyphenyl)methyl]-1,2,3,4-tetrahydroisoquinolin-2-ium-6,7-diol; bromide can be influenced by various factors, including its ionic nature, polarity, and the presence of hydroxyl groups. Understanding these aspects can be crucial for applications in fields such as pharmacology and materials science.

Key Factors Affecting Solubility:

  • Ionic Nature: Being a bromide salt, the compound is likely to have higher solubility in polar solvents such as water compared to non-polar solvents.
  • Hydroxyl Groups: The presence of multiple -OH groups in the structure can facilitate hydrogen bonding, further enhancing solubility in polar solvents.
  • Temperature: Increased temperatures typically enhance solubility, allowing for greater interactions between the solute and solvent molecules.

Moreover, it is beneficial to consider the following:

  • The solubility may vary depending on the pH of the solution, as protonation states of functional groups influence solubility characteristics.
  • In organic solvents, the compound might exhibit limited solubility, primarily due to its polar nature.

In summary, the solubility of 1-[(3,4-dihydroxyphenyl)methyl]-1,2,3,4-tetrahydroisoquinolin-2-ium-6,7-diol; bromide is expected to be significantly higher in polar solvents due to its ionic and hydrophilic characteristics, making it an interesting compound for further research and practical applications.

Interesting facts

Interesting Facts about 1-[(3,4-Dihydroxyphenyl)methyl]-1,2,3,4-tetrahydroisoquinolin-2-ium-6,7-diol; Bromide

This fascinating compound presents a unique intersection of organic chemistry and pharmacology. Known for its complex structure, it is a member of the tetrahydroisoquinoline family, which is significant due to its various biological activities.

Key Characteristics

  • Bioactive Potential: Many tetrahydroisoquinolines exhibit notable pharmacological properties, including neuroprotective effects, anti-inflammatory, and potential anticancer activities.
  • Relationship with Dopamine: The presence of the isoquinoline structure in this compound suggests possible interactions with dopamine receptors, which is crucial in research related to neurological disorders.
  • Phenolic Groups: The 3,4-dihydroxyphenyl moiety is especially significant in terms of antioxidant activity, which can help combat oxidative stress in biological systems.

As a scientist or chemistry student, you might be intrigued by how such compounds can serve as templates for drug design and development. Their intricate chemical features and diverse biological activities make them excellent candidates for medicinal chemistry research. The compound's salt form (bromide) also highlights the importance of ionic interactions in enhancing stability and solubility, which are essential attributes for therapeutic applications.

In studying this compound, researchers often explore:

  • Its synthesis pathways and reaction mechanisms
  • Biological assays to establish its therapeutic potential
  • Structural modifications to enhance efficacy or reduce toxicity

In conclusion, 1-[(3,4-dihydroxyphenyl)methyl]-1,2,3,4-tetrahydroisoquinolin-2-ium-6,7-diol; bromide continues to be a subject of interest in medicinal chemistry due to its promising biological activities and potential therapeutic applications.

Synonyms
THPV HBr
Tetrahydropapaveroline bromide
1,2,3,4-Tetrahydropapaveroline HBr
NSC 118071
Bromhydrate de tetrahydropapaveroline [French]
UNII-D7HN447UC9
Papaveroline, 1,2,3,4-tetrahydro-, hydrobromide
Bromhydrate de tetrahydropapaveroline
AKOS015897249
1,2,3,4-Tetrahydro-1-(3,4-dihydroxybenzyl)-6,7-isoquinolinediol hydrobromide
6,7-ISOQUINOLINEDIOL, 1,2,3,4-TETRAHYDRO-1-(3,4-DIHYDROXYBENZYL)-, HYDROBROMIDE
6,7-Isoquinolinediol, 1-((3,4-dihydroxyphenyl)methyl)-1,2,3,4-tetrahydro-, HBr
Tetrahydropapaveroline hydrobromide, Norlaudanosoline hydrobromide