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Identification
Molecular formula
C16H17NO4
CAS number
957-75-5
IUPAC name
1-[(3,4-dihydroxyphenyl)methyl]-1,2,3,4-tetrahydroisoquinoline-6,7-diol
State
State
At room temperature, the compound is typically in a solid state. It is often synthesized in its hydrochloride salt form for improved handling and application in research settings.
Melting point (Celsius)
168.00
Melting point (Kelvin)
441.15
Boiling point (Celsius)
300.00
Boiling point (Kelvin)
573.15
General information
Molecular weight
273.28g/mol
Molar mass
273.2760g/mol
Density
1.4105g/cm3
Appearence
The compound is a white to off-white powder, known for its appearance as a solid crystalline powder. It is often used in its hydrochloride form for increased stability and solubility in aqueous solutions.
Comment on solubility

Solubility of 1-[(3,4-dihydroxyphenyl)methyl]-1,2,3,4-tetrahydroisoquinoline-6,7-diol

The solubility of 1-[(3,4-dihydroxyphenyl)methyl]-1,2,3,4-tetrahydroisoquinoline-6,7-diol is a complex subject due to its unique chemical structure. In general, several factors can influence the solubility of this compound:

  • Polarity: The presence of multiple hydroxyl (-OH) groups significantly increases the polarity of the molecule, which often enhances solubility in polar solvents like water.
  • Hydrogen Bonding: The multitude of hydroxyl groups can form hydrogen bonds with water molecules, promoting higher solubility levels.
  • Molecular Interactions: The aromatic rings can lead to π-π stacking and other van der Waals interactions, which might affect solubility in non-polar solvents.
  • pH Dependence: The solubility is likely pH-dependent due to ionizable groups, which may alter the compound’s solubility in various pH environments.

However, it should be noted that while theoretical predictions of solubility might suggest good solubility characteristics, empirical testing is necessary for definitive conclusions. As a rule of thumb, compounds with high polarity and extensive hydrogen bonding capabilities typically exhibit enhanced solubility in aqueous environments.

In summary, while the solubility of 1-[(3,4-dihydroxyphenyl)methyl]-1,2,3,4-tetrahydroisoquinoline-6,7-diol is influenced by its unique structure, experimental data is crucial to confirm its practical solubility properties.

Interesting facts

Exploring 1-[(3,4-Dihydroxyphenyl)methyl]-1,2,3,4-tetrahydroisoquinoline-6,7-diol

1-[(3,4-Dihydroxyphenyl)methyl]-1,2,3,4-tetrahydroisoquinoline-6,7-diol is a fascinating compound that combines elements of both structural complexity and potential biological activity. This compound belongs to the isoquinoline family, which is noteworthy for its presence in a variety of natural products and has been associated with diverse pharmaceutical applications. Here are some interesting aspects:

  • Pharmacological Potential: Compounds related to isoquinoline structures often exhibit a range of bioactivities, including antimicrobial, anti-inflammatory, and anticancer properties. This particular compound may hold similar promise and is a subject of ongoing research in drug development.
  • Structural Features: The presence of a dihydroxyphenyl group adds to the compound's reactivity and potential for forming hydrogen bonds, which can enhance its interactions with biological targets, making it an interesting candidate for studies in medicinal chemistry.
  • Natural Occurrence: Isoquinolines are frequently found in various plant species, suggesting that compounds like this one may play significant roles in plant defense mechanisms and could provide leads for developing new therapeutic agents derived from natural sources.
  • Research Significance: The study of such complex organic molecules is not only crucial for understanding their biological roles but also offers insights into the development of synthetic methods that can yield novel compounds with tailored properties.

As researchers continue to investigate the myriad applications of isoquinoline derivatives, 1-[(3,4-dihydroxyphenyl)methyl]-1,2,3,4-tetrahydroisoquinoline-6,7-diol stands out as a captivating subject for future studies. It encapsulates the convergence of chemistry and biology, embodying the intricate relationships that govern molecular interactions in living systems.

As we delve deeper into the world of organic compounds, it's essential to keep an open mind regarding the potential these structures may have in science and medicine. The journey of discovery never really ends!

Synonyms
Tetrahydropapaveroline
Norlaudanosoline
4747-99-3
(R,S)-Norlaudanosoline
1-[(3,4-dihydroxyphenyl)methyl]-1,2,3,4-tetrahydroisoquinoline-6,7-diol
V1EWJ6B8KY
(RS)-NORLAUDANOSOLINE
(+/-)-tetrahydropapaveroline
CHEMBL19068
(+/-)-NORLAUDANOSOLINE
CHEBI:28770
1-(3,4-dihydroxybenzyl)-1,2,3,4-tetrahydroisoquinoline-6,7-diol
6,7-Isoquinolinediol, 1-((3,4-dihydroxyphenyl)methyl)-1,2,3,4-tetrahydro-
Tetrahydroxypapaveroline
UNII-V1EWJ6B8KY
Oprea1_179526
SCHEMBL221137
DTXSID70963850
Norlaudanosoline Hydrobromide Salt
ABXZOXDTHTTZJW-UHFFFAOYSA-N
TETRAHYDROPAPAVEROLINE [MI]
BDBM50027331
STL565699
Papaveroline, 1,2,3,4-tetrahydro-
AKOS037623582
TETRAHYDROPAPAVEROLINE, (+/-)-
C06350
Q27103884
Z2752228094
1-(3,4-Dihydroxybenzyl)-1,2,3,4-tetrahydro-6,7-isoquinolinediol #
6,7-dihydroxy-1-(3',4'-dihydroxybenzyl)-1,2,3,4-tetrahydroisoquinoline
1-((3,4-DIHYDROXYPHENYL)METHYL)-1,2,3,4-TETRAHYDRO-6,7-ISOQUINOLINEDIOL
1-[(3,4-dihydroxyphenyl)methyl]-1,2,3,4-tetrahydroisoquinoline-6,7-diol hydrobromide (JW8-5)