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Tetrabenazine

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Identification
Molecular formula
C19H27NO3
CAS number
58-32-2
IUPAC name
1-[(3,4-dimethoxyphenyl)methyl]-2-[10-[1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]decyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-2-ium;methyl sulfate
State
State

This compound is in a solid state at room temperature.

Melting point (Celsius)
131.00
Melting point (Kelvin)
404.15
Boiling point (Celsius)
429.15
Boiling point (Kelvin)
702.30
General information
Molecular weight
317.45g/mol
Molar mass
317.4500g/mol
Density
1.1185g/cm3
Appearence

Tetrabenazine appears as a white to pale yellow crystalline powder. The compound is often utilized in its crystalline form for pharmaceutical applications.

Comment on solubility

Solubility Characteristics

The compound 1-[(3,4-dimethoxyphenyl)methyl]-2-[10-[1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]decyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-2-ium; methyl sulfate exhibits intriguing solubility properties.

Key Points on Solubility:

  • Polar Nature: Due to the presence of the methyl sulfate group, the compound demonstrates increased polarity, which typically enhances solubility in polar solvents like water.
  • Solvent Compatibility: It is likely to be soluble in common polar solvents such as ethanol, methanol, and acetone, but may have limited solubility in non-polar solvents.
  • Ionization Potential: The ionizable sulfate group may facilitate dissolution in aqueous media by enhancing interaction with water molecules.
  • Temperature Dependency: Solubility can be temperature dependent, with higher temperatures often leading to increased solubility. Therefore, it is advisable to conduct solubility tests at various temperatures for accurate data.

In summary, while this compound shows potential for good solubility in polar environments due to its structural features, it is essential to evaluate its solubility under different conditions to fully understand its behavior in various mediums.

Interesting facts

Interesting Facts about 1-[(3,4-dimethoxyphenyl)methyl]-2-[10-[1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]decyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-2-ium; methyl sulfate

This compound belongs to a class of chemicals known for their complex structures and intriguing properties. Here are some notable facts that highlight its significance:

  • Chemical Structure: The compound features two major isoquinoline units, a class of compounds known for their biological activity. Isoquinolines can exhibit a range of effects on living organisms, making them subjects of interest in medicinal chemistry.
  • Pharmacological Potential: Many isoquinoline derivatives have shown promise in treating various diseases, including cancer and neurological disorders. This compound’s unique molecular arrangement may enhance such properties.
  • Dimethoxy Groups: The presence of dimethoxy groups indicates a potential for increased solubility and reactivity, facilitating interactions within biological systems. Aromatic compounds with methoxy groups often display enhanced lipophilicity.
  • Structure-Activity Relationship (SAR): Understanding the structural components of this compound can aid scientists in predicting its biological activity, which is essential for drug design and discovery.
  • History: Compounds like this one, rich in molecular complexity, often have historical significance in the study of natural products and synthetic chemistry, showcasing the evolution of drug development over decades.
  • Research Awareness: The compound is part of ongoing research efforts aimed at better understanding complex organic compounds and their potential applications in pharmaceuticals and other industries.

As with many compounds of this nature, the deeper one investigates, the more fascinating insights can be uncovered. Scientists are continuously exploring the vast potential that complexes like this may hold for the future of therapeutic interventions.

Synonyms
Laudexium methylsulfate
Laudexium metilsulfate
3253-60-9
Laudolissin
Laudexium methyl sulfate
Laudexium methylsulphate
Laudexenium methyl sulfate
Laudolissin methosulphate
Laudexium methyl sulphate
Laudexii metilsulfas [INN-Latin]
UNII-D067KDG4NU
D067KDG4NU
Laudexium metilsulfate [INN]
Metilsulfate de laudexium [INN-French]
Metilsulfato de laudexio [INN-Spanish]
LAUDEXIUM METHYL SULFATE [MI]
Isoquinolinium, 2,2'-decamethylenebis(1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-veratryl-, bis(methyl sulfate)
Laudexii metilsulfas (INN-Latin)
Metilsulfate de laudexium (INN-French)
Metilsulfato de laudexio (INN-Spanish)
laudexium (cation)
Metilsulfato de laudexio
Metilsulfate de laudexium
Laudexium (methylsulfate)
2,2'-Decamethylenebis(1,2,3,4-tetrahydro)-6,7-dimethoxy-2-methyl-1-veratrylisoquinolium methylsulfate
sulfonatooxymethane
1-[(3,4-dimethoxyphenyl)methyl]-2-[10-[1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]decyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-2-ium;methyl sulfate
2,2'-(decane-1,10-diyl)bis(1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-2-ium) methyl sulfate
Laudexii metilsulfas
SCHEMBL1170701
CHEMBL2106395
DTXSID301029355
HY-122471A
NS00123370
Q15051950
1-[(3,4-Dimethoxyphenyl)methyl]-2-[10-[1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]decyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-2-ium; meth