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Apomorphine hydrochloride

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Identification
Molecular formula
C17H17NO2·HCl
CAS number
58-00-4
IUPAC name
1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-ium;chloride
State
State

Apomorphine hydrochloride, at room temperature, is typically a solid and is supplied as a crystalline powder. It is typically soluble in water, forming clear solutions at the concentrations used for medical applications. Attention to light sensitivity is necessary when handling this compound.

Melting point (Celsius)
243.00
Melting point (Kelvin)
516.15
Boiling point (Celsius)
353.40
Boiling point (Kelvin)
626.55
General information
Molecular weight
303.35g/mol
Molar mass
303.3520g/mol
Density
1.2075g/cm3
Appearence

Apomorphine hydrochloride is a white to off-white crystalline powder. It is sensitive to light and may discolor to a green or blue tint upon exposure to air and light. It should be stored protected from light and moisture to maintain stability.

Comment on solubility

Solubility of 1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-ium;chloride

The compound 1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-ium;chloride exhibits notable solubility characteristics that can be influenced by several factors:

  • Polar Solvents: This compound is likely to exhibit good solubility in polar solvents due to the presence of the quaternary ammonium moiety associated with the chloride anion.
  • Non-polar Solvents: Conversely, solubility in non-polar solvents may be significantly lower, as the presence of methoxy groups increases the polar character of the molecule.
  • pH Dependence: The solubility may also depend on the pH of the solution, as the ionization state of the compound can change, affecting how well it dissolves.
  • Temperature Effects: Increasing temperature often enhances solubility, so solubility testing at various temperatures can provide insights into its behavior.

It can be expected that the compound's solubility is markedly different in various environments, showcasing the intricate relationship between chemical structure and solubility properties. Understanding these interactions is crucial for applications in medicinal chemistry and related fields.

Interesting facts

Interesting Facts about 1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-ium;chloride

This unique chemical compound belongs to the class of tetrahydroisoquinoline derivatives, which are known for their diverse biological activities. Here are some noteworthy points:

  • Pharmacological Potential: Compounds like this one often exhibit significant pharmacological potential, particularly in the realm of neurochemistry. They may serve as *ligands* for various neuronal receptors, influencing mood and perception.
  • Structure-Activity Relationship: The presence of multiple methoxy groups in the structure can enhance its lipophilicity, which may lead to increased bioavailability. Analyzing the relationship between structure and activity assists researchers in the design of more effective pharmaceuticals.
  • Natural Occurrence: Tetrahydroisoquinolines are frequently found in plants and have been studied for their potential *natural product synthesis.* Exploring these compounds paves the way for drug discovery from natural sources.
  • Research Applications: This compound can be a valuable tool in scientific research, particularly in studies examining the effects of certain neurotransmitters in the brain, such as *dopamine* and *serotonin.*
  • Historical Context: Compounds in this class have shown interesting historical significance in traditional medicine practices. They’ve been used to treat various ailments, demonstrating the intersection of chemistry and historical medicinal practices.

Overall, the compound 1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-ium;chloride embodies the rich interplay between structure and biological activity, making it a compound of interest for both current research and future applications in medicinal chemistry.

Synonyms
EINECS 229-213-9
NSC 118072
1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-ium chloride
Papaverine, 1,2,3,4-tetrahydro-, hydrochloride
1,2,3,4-Tetrahydro-6,7-dimethoxy-1-veratryl-isoquinoline hydrochloride
ISOQUINOLINE, 1,2,3,4-TETRAHYDRO-6,7-DIMETHOXY-1-VERATRYL-, HYDROCHLORIDE
NS00082186
A24916
1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-ium;chloride
1-(3,4-Dimethoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride;Tetrahydropapaverine hydrochloride