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Tetrabenazine

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Identification
Molecular formula
C19H27NO3
CAS number
58-46-8
IUPAC name
1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinoline
State
State

At room temperature, Tetrabenazine is a solid.

Melting point (Celsius)
128.50
Melting point (Kelvin)
401.65
Boiling point (Celsius)
484.15
Boiling point (Kelvin)
757.30
General information
Molecular weight
317.43g/mol
Molar mass
317.3940g/mol
Density
1.2100g/cm3
Appearence

Tetrabenazine appears as a white to slightly yellowish crystalline powder.

Comment on solubility

Solubility of 1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinoline

The solubility of 1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinoline is an intriguing topic of discussion due to its complex molecular structure. This compound incorporates several methoxy groups and an isoquinoline core, which significantly influences its solubility characteristics.

Factors Influencing Solubility

The solubility behavior can be summarized by considering several key factors:

  • Molecular Structure: The presence of multiple methoxy groups increases the hydrophilicity, potentially enhancing solubility in polar solvents.
  • Hydrogen Bonding: The ability of the compound to form hydrogen bonds may facilitate solubility in certain solvents.
  • Solvent Polarity: Solubility is generally higher in polar solvents such as water or alcohols compared to nonpolar solvents.

Moreover, studies suggest that such compounds tend to exhibit better solubility profiles when:

  • **Dissolved in organic solvents** like ethanol or dimethyl sulfoxide (DMSO).
  • **Warmed**, since increased temperature often improves solubility for organic compounds.

In conclusion, while the precise solubility of 1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinoline can vary greatly based on solvent choice and experimental conditions, it is likely to demonstrate *moderate to good solubility* in polar organic solvents, aided by its unique structural features.

Interesting facts

Interesting Facts about 1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinoline

This intriguing compound belongs to the class of isoquinolines, which are known for their complex structures and varied biological activities. Here are some captivating aspects of this compound:

  • Bioactive Potential: Isoquinoline derivatives, such as this compound, have been extensively studied for their potential therapeutic effects. They are often associated with various biological activities, including anticancer, antimicrobial, and anti-inflammatory properties.
  • Complex Structure: The presence of multiple methoxy groups in the structure enhances the molecule's lipophilicity and, possibly, its biological activity. The three-dimensional orientation of those substituents can greatly influence the compound's interactions with biological targets.
  • Synthetic Pathways: The synthesis of this compound may involve several intricate steps, showcasing the ingenuity of organic chemists. Researchers often explore different synthetic routes to optimize yields and control stereochemistry, reflecting the compound's sophisticated nature.
  • Pharmacological Studies: Investigations into the pharmacological effects of this compound might reveal significant insights into potential medicinal applications. As scientists continue to explore isoquinolines, the hope is that new therapies will emerge that can address various diseases.

As chemists delve deeper into the properties and applications of this compound, they might uncover new avenues for research and therapeutic development. The dynamic nature of such compounds makes them a hot topic in both pharmaceuticals and organic chemistry.

Synonyms
1699-51-0
(+-)-Laudanosine
Laudanosine
DL-Laudanosine
1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline
(R,S)-Laudanosine
Laudanosine (R,S)
20412-65-1
C21H27NO4
1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinoline
NSC35045
Isoquinoline,1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-, (1R)-
SMR000064381
EINECS 216-923-9
NSC 94267
Veraisoquin
dl-Laudanosin
AI3-61890
NSC-35045
Prestwick_292
MFCD00006910
5',8-Dimethoxylaudanosine hydrochloride
(A+/-)-Laudanosine
Spectrum_000863
(.+-.)-Laudanosine
SpecPlus_000088
Prestwick0_000591
Prestwick1_000591
Prestwick2_000591
Prestwick3_000591
Spectrum2_000663
Spectrum3_000112
Spectrum4_000934
Spectrum5_001625
(.+/-.)-Laudanosine
(+-)-1,2,3,4-Tetrahydro-6,7-dimethoxy-2-methyl-1-veratrylisoquinoline
DL-Laudanosine (Standard)
1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline
CHEMBL1407
ISOQUINOLINE, 1,2,3,4-TETRAHYDRO-6,7-DIMETHOXY-2-METHYL-1-VERATRYL-, (+-)-
Oprea1_379167
BSPBio_000462
BSPBio_001724
KBioGR_001488
KBioSS_001343
MLS000060551
MLS002634637
DivK1c_006184
SCHEMBL466529
SPBio_000725
SPBio_002681
BPBio1_000510
CHEBI:91599
KBio1_001128
KBio2_001343
KBio2_003911
KBio2_006479
KBio3_000864
DTXSID00871873
HMS1569H04
HMS2096H04
HMS2271K11
AAA08563
EX-A3381
NSC94267
BDBM50270376
CCG-38566
NSC-94267
NSC331268
STL570293
AKOS001094404
AKOS022144164
FL52345
HY-122489R
NSC-331268
(1)-1-((3,4-Dimethoxyphenyl)methyl)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methylisoquinoline
1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoqu inoline
NCGC00017301-02
NCGC00142367-01
AS-37336
Isoquinoline, 1-((3,4-dimethoxyphenyl)methyl)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-, (+-)-
DB-043801
DB-180391
HY-122489
AB00052572
CS-0085743
DL-Laudanoside; N-Methyltetrahydropapaverine
NS00002032
EN300-180011
AB00052572-12
BRD-A24817035-001-05-4
Q27163429
Z57474215
Isoquinoline,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-veratryl-
(.+/-.)-1,2,3,4-Tetrahydro-6,7-dimethoxy-2-methyl-1-veratrylisoquinoline
1,2,3,4-Tetrahydro-6,7-dimethoxy-1-(3,4-dimethoxybenzyl)-2-methylisoquinoline
Isoquinoline, 1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-veratryl-, (.+/-.)-
Isoquinoline,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-veratryl-, (.+-.)-
Isoquinoline,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-
Isoquinoline, 1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-, (.+/-.)-
Isoquinoline,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-, (.+-.)-