Skip to main content

Nuciferine

ADVERTISEMENT
Identification
Molecular formula
C19H21NO3Cl
CAS number
475-83-2
IUPAC name
1-[(3,4,5-trimethoxyphenyl)methyl]-1,2,3,4-tetrahydroisoquinolin-2-ium-6,7-diol;chloride
State
State
At room temperature, nuciferine chloride is typically in a solid state. Given its ionic nature, it is not volatile or gaseous under standard conditions, and it is frequently encountered as a powder or crystalline solid.
Melting point (Celsius)
46.85
Melting point (Kelvin)
320.00
Boiling point (Celsius)
408.15
Boiling point (Kelvin)
681.30
General information
Molecular weight
311.36g/mol
Molar mass
311.3640g/mol
Density
1.3260g/cm3
Appearence

Nuciferine chloride appears as a crystalline, white to off-white solid. It may also form as a powder with a possible yellowish tint due to impurities or other factors.

Comment on solubility

Solubility of 1-[(3,4,5-trimethoxyphenyl)methyl]-1,2,3,4-tetrahydroisoquinolin-2-ium-6,7-diol;chloride

The solubility characteristics of the compound 1-[(3,4,5-trimethoxyphenyl)methyl]-1,2,3,4-tetrahydroisoquinolin-2-ium-6,7-diol;chloride can be quite intriguing due to its complex structure. Solubility is a critical attribute that influences how substances interact in solutions, and for this specific compound, various factors come into play:

  • Polarity: Given the presence of multiple methoxy groups and the ionic chloride component, this compound is likely to exhibit moderate to high solubility in polar solvents like water and alcohols.
  • Hydrogen Bonding: The hydroxyl groups (–OH) on the diol portion of the compound facilitate hydrogen bonding with solvents, enhancing solubility.
  • Electrostatic Interactions: The quaternary ammonium-like structure suggests that it may engage in strong ionic interactions with polar solvents, further contributing to its solubility profile.

However, it is essential to note that as with many organic compounds, solubility may vary significantly with changes in temperature and concentration. Thus, while it can be expected to dissolve readily in aqueous environments, additional research is advisable to confirm specific solubility values under varying conditions. As a rule of thumb, always consult empirical data when determining solubility for practical applications.

Interesting facts

Interesting Facts about 1-[(3,4,5-trimethoxyphenyl)methyl]-1,2,3,4-tetrahydroisoquinolin-2-ium-6,7-diol;chloride

This fascinating compound, known for its complex structure, falls under the category of isoquinolines, which are valuable in medicinal chemistry due to their diverse biological activities. Here are some key points that highlight its significance:

  • Medicinal Potential: Isoquinolines, including this compound, exhibit a wide range of pharmacological properties. Research indicates they may possess anti-inflammatory, anti-cancer, and neuroprotective effects, making them an area of interest for drug development.
  • Structural Complexity: The presence of a 3,4,5-trimethoxyphenyl group suggests that this compound could interact with various biological targets, enhancing its pharmacological profile. The tetrahydroisoquinoline structure adds to its interesting stereochemistry.
  • Research Applications: Scientists are investigating its potential in treating neurodegenerative diseases like Alzheimer’s. The ability of isoquinolines to cross the blood-brain barrier is crucial in this exploration.
  • Natural Sources: Many isoquinolines are derived from natural products, found in plants and other organisms. This compound may hold the key to understanding better natural remedies and synthesizing new therapeutic agents.

In conclusion, the compound 1-[(3,4,5-trimethoxyphenyl)methyl]-1,2,3,4-tetrahydroisoquinolin-2-ium-6,7-diol;chloride is a prime example of how intricate chemical structures can lead to promising medicinal applications. As researchers delve deeper into its properties, it may unveil innovative pathways for combating various health challenges.

Synonyms
1,2,3,4-Tetrahydro-1-(3,4,5-trimethoxyphenyl)-6,7-isoquinolinediol hydrochloride
18559-63-2
1-[(3,4,5-trimethoxyphenyl)methyl]-1,2,3,4-tetrahydroisoquinolin-2-ium-6,7-diol;chloride
(+-)-Trimethoquinol
Tretoquinol dl-form hydrochloride
100GVI988J
(+-)-Trimetoquinol hydrochloride
Tretoquinol dl-form HCl
UNII-100GVI988J
TMQ, R-(+)
(+-)-1,2,3,4-Tetrahydro-1-(3,4,5-trimethoxybenzyl)-6,7-isoquinolinediol hydrochloride
dl-1-(3,4,5-Trimethoxybenzyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline hydrochloride
6,7-Isoquinolinediol, 1,2,3,4-tetrahydro-1-(3,4,5-trimethoxybenzyl)-, hydrochloride, (+-)-
6,7-Isoquinolinediol, 1,2,3,4-tetrahydro-1-(3,4,5-trimethoxyphenyl)-, hydrochloride