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Testosterone

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Identification
Molecular formula
C19H28O2
CAS number
58-22-0
IUPAC name
1-[(3R,5R,8R,9S,10S,13S,14S,17S)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone
State
State

At room temperature, testosterone is typically found in a solid state in the form of a white crystalline powder. It is commonly available in various forms for therapeutic use including injectables, tablets, and patches.

Melting point (Celsius)
155.00
Melting point (Kelvin)
428.15
Boiling point (Celsius)
431.00
Boiling point (Kelvin)
704.15
General information
Molecular weight
288.43g/mol
Molar mass
288.4310g/mol
Density
1.1450g/cm3
Appearence

Testosterone is a white to off-white crystalline powder. It is odorless and stable under normal conditions. As a steroid hormone, it is often processed into various forms, including gels and injectables, for medical use.

Comment on solubility

Solubility of 1-[(3R,5R,8R,9S,10S,13S,14S,17S)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone

The solubility of this complex organic compound can be considered through several key factors. Due to its intricate molecular structure, which contains multiple chiral centers and a substantial hydrocarbon framework, its solubility characteristics can vary significantly based on the solvent used.

Factors Influencing Solubility:

  • Polarity of the Solvent: This compound, with its large hydrophobic regions, is likely to exhibit low solubility in polar solvents such as water. In contrast, it may dissolve more readily in non-polar or weakly polar organic solvents like hexane or chloroform.
  • Temperature: Solubility typically increases with temperature. Thus, in situations where the solvent is heated, we may observe improved solubility.
  • Potential for Hydrogen Bonding: The presence of the hydroxyl group may facilitate solubility in solvents capable of hydrogen bonding, albeit to a limited extent due to competition with the overall hydrophobic character of the molecule.

It is important to note that the actual solubility of this compound can be best determined through empirical measurements.

Conclusion:

In summary, the solubility of 1-[(3R,5R,8R,9S,10S,13S,14S,17S)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone is largely influenced by its hydrophobic characteristics and the nature of the solvent employed, making it a compound of significant interest for further research in solubility studies.

Interesting facts

Interesting Facts about 1-[(3R,5R,8R,9S,10S,13S,14S,17S)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone

This compound is a fascinating example of a steroid-like structure, possessing a complex arrangement of carbon atoms that creates a unique molecular framework. Here are some interesting insights:

  • Steroid Backbone: The presence of multiple rings in the structure indicates that this compound is likely to exhibit characteristics similar to steroids, involved in many biological processes.
  • Hydroxyl Group: The hydroxyl functional group (–OH) within its molecular structure can significantly affect the compound's reactivity and interactions with biological systems, potentially influencing its role as a precursor in hormone synthesis.
  • Natural Occurrence: Compounds with similar structures are often found in nature as part of larger biological systems, which makes them of particular interest for studying natural product chemistry.
  • Potential Applications: Given its structural complexity, this compound may hold potential in medicinal chemistry, especially in therapeutic applications related to hormonal treatments or metabolic disorders.

Furthermore, the stereochemistry of the compound, indicated by the careful arrangement of the R and S designations, is crucial in determining its biological activity. As the famous chemist Robert H. Grubbs said, "The beauty of chemistry lies in its ability to create complex molecules that can affect life in profound ways." This compound embodies that sentiment, with its intricate design relevant to both chemical research and pharmaceutical applications.

The ongoing study of such compounds not only expands our understanding of organic chemistry but also opens avenues for innovative research in drug development. With the right investigations, compounds like this can lead to breakthroughs in health science.

Synonyms
Pregnanolone
ELTANOLONE
128-20-1
3alpha-Hydroxy-5beta-pregnan-20-one
Eltanolona
Pregnan-3alpha-ol-20-one
Eltanolonum
Pregnan-20-one, 3-hydroxy-, (3alpha,5beta)-
(3alpha,5beta)-3-hydroxypregnan-20-one
BXO86P3XXW
Kabi 2213
Kabi-2213
NSC-82867
CHEBI:1712
Allopregnan-3 beta-ol-20-one
DTXSID1046342
SKF-6455
3 Hydroxypregnan 20 one
1-[(3R,5R,8R,9S,10S,13S,14S,17S)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone
Pregnan 3alpha ol 20 one
3 alpha, 5 beta-Tetrahydroprogesterone
3 alpha-Hydroxy-5 beta-pregnan-20-one
5beta-Pregnan-20-one, 3alpha-hydroxy-
Allopregnan 3 beta ol 20 one
beta-ol-20-one, Allopregnan-3
DTXCID101474386
NSC82867
3beta Hydroxy 5alpha pregnan 20 one
3 alpha, 5 beta Tetrahydroprogesterone
3 alpha Hydroxy 5 beta pregnan 20 one
alpha-Hydroxy-5 beta-pregnan-20-one, 3
beta-pregnan-20-one, 3 alpha-Hydroxy-5
1-((3R,5R,8R,9S,10S,13S,14S,17S)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta(a)phenanthren-17-yl)ethanone
RefChem:868470
Pregnanolone, (3alpha,5beta)-
Pregnanolone II
Eltanolone [INN]
SKF 6455
NSC 82867
3alpha-Hydroxy-5beta-pregnane-20-one
5beta-Pregnan-3alpha-ol-20-one
Pregnan-3.alpha.-ol-20-one
3alpha-Hydroxy-5beta-tetrahydroprogesterone
MFCD00067137
5B-Pregnan-3A-ol-20-one
3.alpha.-Hydroxy-5.beta.-pregnan-20-one
5?-Pregnan-3?-ol-20-one
5.beta.-Pregnan-20-one, 3.alpha.-hydroxy-
3.alpha.,5.beta.-Epimeric pregnanolone
3.alpha.-Hydroxy-5.beta.-tetrahydroprogesterone
Pregnan-20-one, 3-hydroxy-, (3.alpha.,5.beta.)-
Eltanolonum [INN-Latin]
Eltanolona [INN-Spanish]
1-((3R,5R,8R,9S,10S,13S,14S,17S)-3-hydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)ethan-1-one
3alpha,5beta-Epimeric pregnanolone
pregnan-3a-ol-20-one
MLS002694512
UNII-BXO86P3XXW
BRN 4785659
3-alpha-Hydroxy-5-beta-pregnan-20-one
NCGC00163287-01
P9N
3alpha,5beta-THP
Pregnanolone, (3alpha,5beta)-isomer
WLN: L E5 B666TJ A1 E1 FV1 OQ
5-beta-Pregnan-20-one, 3-alpha-hydroxy-
Pregnan-20-one, 3-hydroxy-, (3a,5b)-
ELTANOLONE [MART.]
SCHEMBL56664
Pregnanolone, (3beta)-isomer
Pregnanolone, (3alpha)-isomer
Pregnanolone, (5alpha)-isomer
CHEMBL210952
3.alpha.,5.beta.-Pregnanolone
3a-Hydroxy-5b-pregnan-20-one
GTPL11534
3alpha,5beta-tetrahydroprogesterone
Tox21_112042
(3a,5b)-3-Hydroxypregnan-20-one
LMST02030175
Pregnanolone, (3beta, 5beta)-isomer
Pregnanolone, (3alpha,5alpha)-isomer
Pregnanolone, (3beta, 5alpha)-isomer
DB12308
FP27148
5 beta -Pregnan-3 alpha -ol-20-one
5.beta.-Pregnan-3.alpha.-ol-20-one
CAS-128-20-1
Pregnan-20-one, (3.alpha.,5.beta.)-
(3alpha,5beta)-3-Hydroxy-pregnan-20-one
PREGNAN-3.ALPHA.-OL-20-ONE [MI]
Pregnanolone, (3beta, 5beta,14beta)-isomer
C05480
G77796
Pregnan-20-one, 3-hydroxy-, (3|A,5|A)-
Pregnanolone, (3beta, 5beta, 17alpha)-isomer
Pregnanolone, (3beta, 5alpha, 17alpha)-isomer
128P201
3-Hydroxypregnan-20-one, (3.alpha.,5.beta.)-
Pregnanolone, (3alpha, 5beta, 17-alpha)-isomer
Q18344323
Pregnanolone, (3beta, 5alpha, 8alpha, 17beta)-isomer
(3?,5?)-3-Hydroxy-pregnan-20-one;3-Deoxo-3?-hydroxy-5?-dihydroprogesterone;3?,5?-Pregnanolone
110350-90-8