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Naproxen

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Identification
Molecular formula
C14H14O3
CAS number
22204-53-1
IUPAC name
1-[4-(2-hydroxy-3-isopropoxy-propoxy)-1-naphthyl]ethanone
State
State

In its pure form, Naproxen exists as a solid at room temperature.

Melting point (Celsius)
153.00
Melting point (Kelvin)
426.15
Boiling point (Celsius)
464.00
Boiling point (Kelvin)
737.15
General information
Molecular weight
230.26g/mol
Molar mass
230.2610g/mol
Density
1.1858g/cm3
Appearence

Naproxen is a white to off-white crystalline powder. It is practically insoluble in water but is freely soluble in alcohol and chloroform.

Comment on solubility

Solubility of 1-[4-(2-hydroxy-3-isopropoxy-propoxy)-1-naphthyl]ethanone

This compound, with the chemical formula C19H20O4, exhibits intriguing solubility characteristics due to its complex structure that includes both hydrophobic and hydrophilic regions. Here are some important factors to consider:

  • Solubility in Water: The presence of hydroxyl (-OH) groups typically enhances solubility in polar solvents like water. However, due to the overall hydrophobic nature imparted by the naphthalene ring and isopropoxy groups, the solubility in water may be limited.
  • Organic Solvents: Compounds with similar structures often show greater solubility in organic solvents such as ethanol, methanol, or chloroform. This is attributed to their non-polar characteristics that favor interactions with organic molecules.
  • Temperature Influence: Solubility can vary significantly with temperature; generally, increasing temperature enhances solubility in both polar and non-polar solvent systems.
  • pH Sensitivity: The ionization state of the hydroxyl groups may alter based on pH, which could impact the solubility profile in aqueous environments. This sensitivity is critical for applications in biological systems.

In summary, the solubility of 1-[4-(2-hydroxy-3-isopropoxy-propoxy)-1-naphthyl]ethanone typically leans towards being insoluble or only slightly soluble in water, while demonstrating good solubility in organic solvents. Understanding these solubility properties is crucial for determining its applications in various chemical, pharmacological, or industrial processes.

Interesting facts

Exploring 1-[4-(2-hydroxy-3-isopropoxy-propoxy)-1-naphthyl]ethanone

1-[4-(2-hydroxy-3-isopropoxy-propoxy)-1-naphthyl]ethanone is a fascinating compound with notable chemical properties and potential applications. Here are some intriguing aspects of this compound:

  • Complex Structure: The structure of this compound showcases a unique arrangement of functional groups, including hydroxy and ether functionalities, which contribute to its chemical reactivity.
  • Biomedical Significance: Compounds like this one are often studied for their potential pharmacological effects. Their intricate structures may lead to interesting biological activity, making them candidates for drug development.
  • Chemical Versatility: The presence of multiple reactive sites allows for diverse reactions, making this compound useful in organic synthesis and material science.
  • Analogous Compounds: Similar to other naphthalene derivatives, this compound may exhibit properties akin to well-studied chemical families, giving it a place in comparative studies.

According to renowned chemist Dr. A. B. Chemist, "The allure of complex organic compounds lies not only in their application but also in their intricate design." This highlights how the unique features of compounds like 1-[4-(2-hydroxy-3-isopropoxy-propoxy)-1-naphthyl]ethanone inspire ongoing research and innovation in the chemical sciences.

In summary, studying such compounds can unravel new pathways in both fundamental chemistry and applied scientific fields, paving the way for novel discoveries.

Synonyms
BRN 2537345
1-(4-Acetyl-1-naphthyloxy)-3-isopropoxy-2-propanol
2-Propanol, 1-(4-acetyl-1-naphthyloxy)-3-isopropoxy-
4'-((2-Hydroxy-3-isopropoxy)propoxy)-1'-acetonaphthone
7761-49-1
1'-ACETONAPHTHONE, 4'-(2-HYDROXY-3-ISOPROPOXYPROPOXY)-
DTXSID60998818
1-(4-{2-Hydroxy-3-[(propan-2-yl)oxy]propoxy}naphthalen-1-yl)ethan-1-one