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Methylphenidate

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Identification
Molecular formula
C14H19NO2
CAS number
113-45-1
IUPAC name
1-[4-(2-morpholinoethyl)-1-phenyl-4-piperidyl]butan-1-one
State
State
At room temperature, methylphenidate is found as a solid.
Melting point (Celsius)
187.00
Melting point (Kelvin)
460.15
Boiling point (Celsius)
415.00
Boiling point (Kelvin)
688.15
General information
Molecular weight
233.31g/mol
Molar mass
233.3060g/mol
Density
1.1200g/cm3
Appearence

Methylphenidate is typically found as a white, odorless crystalline powder. It is classified as a stimulant drug of the piperidine class and is used in various pharmaceutical formulations.

Comment on solubility

Solubility of 1-[4-(2-morpholinoethyl)-1-phenyl-4-piperidyl]butan-1-one

The solubility of 1-[4-(2-morpholinoethyl)-1-phenyl-4-piperidyl]butan-1-one can be quite intriguing due to its structure and functional groups. Here are several critical points to consider:

  • Polar Nature: The presence of the morpholino and piperidyl groups typically enhances the polar character of the molecule, which may contribute to its solubility in polar solvents such as water.
  • Hydrophobic Interactions: Contrary to polar solubility, the phenyl group introduces hydrophobic interactions, which could affect solubility in non-polar solvents as well.
  • Solvent Dependence: The compound may exhibit different solubility profiles in a variety of solvents. For instance, it might be more soluble in organic solvents like ethanol or methanol compared to more hydrophobic solvents.
  • Temperature Effects: Temperature plays a significant role. Increased temperature typically enhances solubility, leading to increased molecular motion and interaction with solvent molecules.

In summary, the solubility of 1-[4-(2-morpholinoethyl)-1-phenyl-4-piperidyl]butan-1-one may be best characterized by its variable properties in response to different solvents and conditions. Understanding its solubility is crucial for its application in pharmaceuticals and chemical synthesis.

Interesting facts

Interesting Facts about 1-[4-(2-morpholinoethyl)-1-phenyl-4-piperidyl]butan-1-one

This compound, often encountered in the field of medicinal chemistry, showcases a fascinating blend of functional groups that contribute to its biological activity. Its unique structure is characterized by a combination of piperidine and morpholine rings, which enhances its interactions with various biological targets.

Key Highlights

  • Pharmacological Potential: The compound is explored for its applications in neuropharmacology, particularly its potential to modulate neurotransmitter systems.
  • Diversity of Structure: The presence of both piperidine and morpholine rings, along with a phenyl group, suggests a versatile interaction profile that may be pivotal in its activity.
  • Research Significance: Due to its complex structure, it serves as a valuable intermediate in the synthesis of compounds aimed at treating psychiatric disorders.

In research environments, the compound is often the subject of structure-activity relationship (SAR) studies, where chemists explore how small modifications can influence its pharmacodynamics. This compound exemplifies the creativity and complexity inherent in drug design, illustrating how specific structural elements can vastly alter a compound's biological effects.

Applications in Medicine

Its potential therapeutic applications can be summarized as follows:

  • Neurotransmitter Modulation: Effectively acts on receptors involved in mood regulation.
  • Patient Treatment: Explored for use in managing various psychological conditions.
  • Research Tool: Its synthetic route offers insights into developing novel pharmacological agents.

As research continues, the insights gained from 1-[4-(2-morpholinoethyl)-1-phenyl-4-piperidyl]butan-1-one may pave the way for new therapeutic advancements. This compound embodies the cutting-edge synthesis strategies and biological explorations in contemporary medicinal chemistry.