Skip to main content

Pirfenidone

ADVERTISEMENT
Identification
Molecular formula
C12H11NO5
CAS number
53179-13-8
IUPAC name
1-[4-(2-oxo-2-pyrrolidin-1-yl-ethyl)piperazin-1-yl]-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one
State
State

At room temperature, pirfenidone is generally in a solid state.

Melting point (Celsius)
105.00
Melting point (Kelvin)
378.15
Boiling point (Celsius)
833.80
Boiling point (Kelvin)
1 106.95
General information
Molecular weight
185.23g/mol
Molar mass
185.2280g/mol
Density
1.2810g/cm3
Appearence

Pirfenidone appears as a white to pale yellow crystalline powder. It is almost odorless and has a bitter taste.

Comment on solubility

Solubility of 1-[4-(2-oxo-2-pyrrolidin-1-yl-ethyl)piperazin-1-yl]-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one

The compound, with the chemical formula C12H11NO5, presents some intriguing characteristics regarding its solubility, which can significantly influence its applications in various fields such as pharmacology and chemistry.

Solubility Insights:

  • Polar vs. Non-Polar: Due to the presence of multiple functional groups, including a piperazine ring and methoxy substitutions, the compound exhibits a balance between polar and non-polar characteristics, which can enhance its solubility in both polar and non-polar solvents.
  • Aqueous Solubility: Although the exact solubility in water is not readily available, compounds with similar structures may demonstrate limited solubility in aqueous solutions, making them more suited for organic solvents.
  • Solvation Effects: The solubility can be influenced by temperature and the nature of the solvent used. For example, higher temperatures can often increase solubility.
  • pH Dependency: Moreover, the ionization of certain functional groups within the compound can lead to varying solubility profiles based on the pH of the solution, which is a crucial factor to consider during formulation.

In summary, while detailed solubility data for this specific compound may be scarce, its structural features suggest a potential for reasonable solubility in various environments. Understanding these properties not only aids in the effective handling of the compound but also plays a critical role in its practical applications.

Interesting facts

Interesting Facts about 1-[4-(2-oxo-2-pyrrolidin-1-yl-ethyl)piperazin-1-yl]-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one

This compound belongs to a class of chemical compounds that exhibit intriguing biological properties. With a complex structure, it incorporates various functional groups that play significant roles in its potential applications:

  • Piperazine Derivative: The presence of a piperazine ring is notable as it often enhances the pharmacological properties of compounds. This structure is frequently found in pharmaceuticals, leading to diverse therapeutic effects.
  • Potential Neuroactive Effects: Due to the presence of a pyrrolidine moiety, studies suggest that this compound may interact with neurotransmitter systems, presenting possibilities for developing novel treatments for mental health disorders.
  • Trimethoxyphenyl Group: The 3,4,5-trimethoxyphenyl segment is particularly interesting; this moiety is often associated with antioxidant activity, which could contribute to overall health benefits.
  • Enone Functionality: This compound features an enone functionality, which is known for its reactivity in organic synthesis. Such a characteristic opens up avenues for the creation of other chemical entities through various transformations.

This compound's synthetic approach may involve multiple reaction steps, showcasing the importance of organic synthesis in advancing chemical research. As a chemistry student, one could appreciate the intricate designs and methodologies involved in developing such a multi-faceted compound.

Furthermore, the exploration of its biological activities can lead to significant discoveries. As the saying goes, "Chemistry is the art of transformation." In this case, each functional group contributes to transforming our understanding of potential medicinal applications.

In summary, 1-[4-(2-oxo-2-pyrrolidin-1-yl-ethyl)piperazin-1-yl]-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one is more than just a chemical formula; it represents a unique blend of structural chemistry and therapeutic potential, making it a candidate of interest for both research and application.

Synonyms
Cinepazime
DTXSID5048261
MD 67350; MD-67350; MD67350; NSC 291562
SCHEMBL8839976
CHEMBL2220667
BCP21376
NDA19748
AKOS032960259
1-[4-(2-oxo-2-pyrrolidin-1-ylethyl)piperazin-1-yl]-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one
NS00050424