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Chloramphenicol base

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Identification
Molecular formula
C11H13ClN2O5
CAS number
56-75-7
IUPAC name
1-[4-[[(2R,5S)-3,4,5-trihydroxytetrahydropyran-2-yl]amino]phenyl]ethanone
State
State

At room temperature, Chloramphenicol base is in a solid state, presenting itself in a crystalline form. It is stable under normal conditions but should be stored in a cool, dry place to maintain its efficacy.

Melting point (Celsius)
149.50
Melting point (Kelvin)
422.65
Boiling point (Celsius)
226.50
Boiling point (Kelvin)
499.65
General information
Molecular weight
323.13g/mol
Molar mass
323.1300g/mol
Density
1.3000g/cm3
Appearence

Chloramphenicol base typically appears as a white to light beige crystalline powder. It is characteristic for pharmaceuticals and is utilized for its antibiotic properties. The compound is sensitive to light and may darken upon prolonged exposure.

Comment on solubility

Solubility of 1-[4-[[(2R,5S)-3,4,5-trihydroxytetrahydropyran-2-yl]amino]phenyl]ethanone

The solubility of the compound 1-[4-[[(2R,5S)-3,4,5-trihydroxytetrahydropyran-2-yl]amino]phenyl]ethanone can be influenced by several factors due to its complex structure. This compound, characterized by its three hydroxyl groups, indicates potential for significant interactions with water.

Factors Affecting Solubility:

  • Hydroxyl Groups: The presence of multiple hydroxyl (-OH) groups typically increases the compound's polarity, enhancing its ability to dissolve in polar solvents like water.
  • Hydrophobic Regions: However, the structure may also include hydrophobic regions which could limit solubility in certain organic solvents.
  • pH Influence: Changes in pH can further impact solubility by altering the ionization state of the compound, possibly making it more soluble in basic or acidic conditions.

In a suitable solvent, it is reasonable to expect that:

  • Higher solubility is likely in aqueous environments due to the polar characteristics of the hydroxyl groups.
  • Moderate solubility may be observed in organic solvents, depending on their own polarities.

In conclusion, the overall solubility of 1-[4-[[[2R,5S)-3,4,5-trihydroxytetrahydropyran-2-yl]amino]phenyl]ethanone is a balancing act between its polar and non-polar characteristics, making it an intriguing subject for further study.

Interesting facts

Exciting Insights into 1-[4-[[(2R,5S)-3,4,5-trihydroxytetrahydropyran-2-yl]amino]phenyl]ethanone

This compound, known for its complex structure and unique functional groups, opens doors to fascinating research avenues in the field of medicinal and organic chemistry. Here are some intriguing aspects of 1-[4-[[(2R,5S)-3,4,5-trihydroxytetrahydropyran-2-yl]amino]phenyl]ethanone:

  • Role in Drug Discovery: Its structural motifs suggest the potential for bioactivity, making it an interesting target for drug development, particularly in the realms of treating diseases associated with metabolic disorders.
  • Sugar Mimicry: The presence of the tetrahydropyran moiety is reminiscent of monosaccharides, indicating the possibility of interactions with sugar-binding proteins, which is critical in various biological processes.
  • Hydroxyl Groups: The three hydroxyl (-OH) groups contribute to the compound's hydrogen-bonding capacity, influencing its solubility and reactivity, which can enhance its pharmacokinetic properties.
  • Stereochemistry and Activity: The specific (2R,5S) stereochemistry may lead to differing biological activities compared to its enantiomers, emphasizing the significance of chirality in drug efficacy and safety.
  • Cross-disciplinary Potential: Beyond chemistry, this compound could interest biologists and pharmacologists due to its potential roles in signaling pathways and cellular interactions.

As stated by prominent chemist Linus Pauling, "The best way to have a good idea is to have a lot of ideas." This compound embodies the essence of that ideal by inspiring innovative research and collaboration across disciplines, furthering our understanding of complex biochemical systems.

In summary, 1-[4-[[[2R,5S)-3,4,5-trihydroxytetrahydropyran-2-yl]amino]phenyl]ethanone not only exemplifies the intricate beauty of chemical structures but also serves as a pivotal player in advancing pharmaceutical chemistry.

Synonyms
ACETOPHENONE, 4'-(ARABINOSYLAMINO)-
28905-03-5
RefChem:1075952
4'-(Arabinosylamino)acetophenone
p-Aminoacetophenone arabinoside
1-(4-(Arabinosylamino)phenyl)ethanone
Ethanone, 1-(4-(arabinosylamino)phenyl)-
N-(4-acetylphenyl)pentopyranosylamine
DTXSID90951537