Loperamide hydrochloride | Solubility of Things

Identification

Molecular formula

C₂₉H₃₁Cl₂FNO₂

CAS number

34552-83-5

IUPAC name

1-[4-(4-fluorophenyl)-4-oxo-butyl]-4-piperidin-1-ium-1-yl-piperidin-1-ium-4-carboxamide;dichloride

State

Loperamide hydrochloride is typically found in solid state at room temperature, appearing as a crystalline powder.

Melting point (Celsius)

224.00

Melting point (Kelvin)

497.15

Boiling point (Celsius)

306.00

Boiling point (Kelvin)

579.15

General information

Molecular weight

513.51g/mol

Molar mass

513.5110g/mol

Density

1.4500g/cm³

Appearence

Loperamide hydrochloride appears as a white to off-white solid, crystalline powder. It is commonly available in tablet or capsule form as a medication.

Comment on solubility

Solubility of 1-[4-(4-fluorophenyl)-4-oxo-butyl]-4-piperidin-1-ium-1-yl-piperidin-1-ium-4-carboxamide; dichloride

This complex compound exhibits interesting solubility characteristics, particularly as it is a salt (dichloride form), which often enhances its solubility in various solvents. Here are a few important points regarding its solubility:

Polar Solvents: Due to the presence of ionic interactions in the dichloride form, this compound is likely to have high solubility in polar solvents such as water. The charged piperidinium groups can interact favorably with water molecules.
Non-Polar Solvents: Conversely, solubility in non-polar solvents is expected to be relatively low. The bulky size and polar groups inhibit dissolution in such media.
Temperature Effects: The solubility may increase with temperature, which is a common behavior for many salt compounds, enabling greater interaction with solvent molecules.
pH Influence: The solubility can also be affected by the pH of the solution, as it may change the ionization status of functional groups present in the compound.

In summary, the compound's solubility profile is significantly influenced by the presence of ionizable groups and their interactions with the solvent. As noted, "solubility is a key factor in determining the bioavailability and efficacy of a compound," making it crucial to consider in practical applications.

Interesting facts

Interesting Facts about 1-[4-(4-fluorophenyl)-4-oxo-butyl]-4-piperidin-1-ium-1-yl-piperidin-1-ium-4-carboxamide; Dichloride

This compound, known for its complex structure, showcases the fascinating intersection of organic chemistry and pharmacology. Here are some intriguing aspects:

Structural Complexity: The compound features multiple functional groups which can play significant roles in its biological activity. The presence of piperidine rings suggests potential neuroactive properties.
Fluorine Substitution: The incorporation of a fluorinated aromatic group (4-fluorophenyl) is notable as fluorine can enhance metabolic stability and lipophilicity. This often results in compounds that are more effective in pharmaceutical applications.
Potential Applications: Due to its structure, this compound could be investigated as a candidate for therapeutic applications, particularly in the treatment of neurological disorders or pain management.
Ionization Properties: As a piperidin-1-ium derivative, this compound may exhibit interesting ionization characteristics that can influence its pharmacokinetics and interaction with biological systems.
Research Significance: Compounds of this nature are often explored in medicinal chemistry for their potential as drug candidates, contributing to the understanding of structure-activity relationships (SAR).

In summary, 1-[4-(4-fluorophenyl)-4-oxo-butyl]-4-piperidin-1-ium-1-yl-piperidin-1-ium-4-carboxamide; dichloride exemplifies the rich potential within synthetic organic compounds, particularly those designed for specific biological activity. It's a prime example of how chemical synthesis can lead to novel entities that pave the way for advancements in medicinal chemistry.

Synonyms

Propitan

1'-(4-(4-Fluorophenyl)-4-oxobutyl)(1,4'-bipiperidine)-4'-carboxamide dihydrochloride

D92202