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Lonafarnib

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Identification
Molecular formula
C27H31N3O
CAS number
193275-84-2
IUPAC name
1-[4-[5-[4-[amino-(cyclohexylamino)methyl]phenyl]-2-furyl]phenyl]-N'-cyclohexyl-methanediamine
State
State

At room temperature, lonafarnib is typically found in a solid state. It is stable under normal conditions of storage and handling.

Melting point (Celsius)
167.00
Melting point (Kelvin)
440.15
Boiling point (Celsius)
688.00
Boiling point (Kelvin)
961.15
General information
Molecular weight
540.73g/mol
Molar mass
540.7300g/mol
Density
1.2410g/cm3
Appearence

Lonafarnib is a white to off-white crystalline solid. It typically appears as a powder that is soluble in various organic solvents.

Comment on solubility

Solubility of 1-[4-[5-[4-[amino-(cyclohexylamino)methyl]phenyl]-2-furyl]phenyl]-N'-cyclohexyl-methanediamine (C27H31N3O)

The solubility of the compound 1-[4-[5-[4-[amino-(cyclohexylamino)methyl]phenyl]-2-furyl]phenyl]-N'-cyclohexyl-methanediamine is an intriguing subject due to its complex structure. Understanding its solubility can be beneficial for various applications, particularly in pharmaceuticals and organic synthesis. Here are some key points regarding its solubility:

  • Polarity: The compound features both hydrophobic cyclohexyl groups and a hydrophilic amino functional group. This suggests that it may have limited solubility in water but could be soluble in organic solvents.
  • Functional Groups: The presence of the amine group potentially allows for hydrogen bonding with water molecules, enhancing solubility in polar solvents to some extent.
  • Steric Hindrance: The bulky cyclohexyl groups may contribute to steric hindrance, which could affect both the dissolution process and the overall solubility of the compound in different media.
  • Potential Solvents: Common solvents that may facilitate the solubility of this compound include ethanol, methanol, and dimethyl sulfoxide (DMSO), while highly polar solvents may be less effective.

In summary, the solubility of C27H31N3O is expected to be moderate, with a dependency on the solvent used and the balance between its hydrophobic and hydrophilic characteristics. As with many organic compounds, solubility assays under different conditions will provide more definitive insights.

Interesting facts

Interesting Facts about 1-[4-[5-[4-[amino-(cyclohexylamino)methyl]phenyl]-2-furyl]phenyl]-N'-cyclohexyl-methanediamine

This compound, with its intricate structure and multiple functional groups, opens the door to various fascinating discussions in the realms of chemistry and medicinal science. Here are some interesting facts:

  • Complex Molecular Architecture: The presence of both cyclohexyl and phenyl groups along with a furan ring showcases the compound's ability to engage in diverse chemical interactions.
  • Potential Pharmaceutical Applications: Compounds like this often intrigue researchers due to their potential as lead compounds in drug development. The amino groups can enhance biological activity and improve solubility.
  • Structure-Activity Relationship (SAR): Understanding how structural changes can impact biological activity is imperative in medicinal chemistry. Substituting different groups on the phenyl rings might yield compounds with improved potency and selectivity for certain biological targets.
  • Synthesis Challenges: The synthesis of such complex organic molecules can be a challenge, often requiring multiple reaction steps and careful management of sterics and electronics to achieve the desired end product.
  • Utility in Materials Science: Beyond pharmaceuticals, compounds with such elaborate structures may exhibit interesting properties useful in material science, such as non-linear optical properties or as precursors for polymers with specialized functionalities.
  • Research Implications: Scientists often collaborate across disciplines, leveraging the unique properties of compounds like this in fields such as organic electronics and nanotechnology.

In summary, 1-[4-[5-[4-[amino-(cyclohexylamino)methyl]phenyl]-2-furyl]phenyl]-N'-cyclohexyl-methanediamine represents a captivating subject for researchers and students alike. Its complex design not only fascinates chemists but also provides various avenues for exploration in both fundamental and applied sciences.

Synonyms
(S,R)-(furan-2,5-diyldibenzene-4,1-diyl)bis(N-cyclohexylmethanediamine)