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4-Aminobutyrophenone

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Identification
Molecular formula
C10H13NO
CAS number
1777-12-6
IUPAC name
1-(4-aminophenyl)butan-1-one
State
State

At room temperature, 4-Aminobutyrophenone is typically found in a solid state. It is characterized by its stable crystalline form which contributes to its solid-state appearance under standard laboratory conditions.

Melting point (Celsius)
69.00
Melting point (Kelvin)
342.15
Boiling point (Celsius)
313.00
Boiling point (Kelvin)
586.15
General information
Molecular weight
163.22g/mol
Molar mass
163.2150g/mol
Density
1.0830g/cm3
Appearence

4-Aminobutyrophenone appears as a white to off-white crystalline solid. Its appearance can vary slightly depending on the purity and specific conditions of handling, but in its standard form, it is typically a fine powder.

Comment on solubility

Solubility of 1-(4-aminophenyl)butan-1-one

1-(4-aminophenyl)butan-1-one, often referred to as a pharmaceutical intermediate, exhibits notable solubility characteristics that can significantly influence its applications. Understanding its solubility can be essential for effective use in various formulations.

Key Points on Solubility:

  • Solvent Interaction: This compound shows preferential solubility in organic solvents like ethanol and methanol, which can be attributed to its hydrophobic butanone structure and the presence of the amine group that can engage in hydrogen bonding.
  • Water Solubility: While 1-(4-aminophenyl)butan-1-one is **not very soluble** in water, it may exhibit limited solubility due to the polar nature of the amine group.
  • Temperature Effects: Solubility tends to increase with temperature; therefore, higher temperatures can enhance its dissolution in solvents.
  • pH Dependency: The solubility can also vary with pH; in acidic conditions, the amine group can become protonated, potentially increasing solubility in aqueous environments.

In summary, the solubility of 1-(4-aminophenyl)butan-1-one is a complex interplay of its molecular structure, solvent properties, and environmental conditions. As highlighted, understanding these factors can optimize its performance in various chemical applications and formulations.

Interesting facts

Interesting Facts about 1-(4-Aminophenyl)butan-1-one

1-(4-Aminophenyl)butan-1-one, a fascinating organic compound, is often recognized for its dual functionality as both a ketone and an amine. Here are some captivating insights that highlight its significance and characteristics:

  • Diverse Applications: This compound plays a crucial role in the synthesis of various pharmaceuticals and agrochemicals, making it invaluable in medicinal chemistry and drug discovery.
  • Synthesis Pathway: The preparation of 1-(4-aminophenyl)butan-1-one can involve innovative reactions that showcase the versatility of synthetic organic chemistry. Chemists often utilize methods such as Friedel-Crafts acylation or reductive amination, providing engaging learning opportunities for students.
  • Biological Activity: Research indicates that compounds with similar structures often exhibit interesting biological properties, including anti-inflammatory and analgesic activities. Investigations into 1-(4-aminophenyl)butan-1-one may unveil novel therapeutic potentials.
  • Structure-Activity Relationship (SAR): Understanding how variations in its chemical structure can influence biological activities is critical. This prompts discussions on the importance of small modifications in pharmaceutical design.
  • Interdisciplinary Relevance: Its study encompasses fields such as pharmacology, medicinal chemistry, and materials science. This adds an interdisciplinary dimension to its research, captivating students from various fields.

As a compound of interest in both academic research and industrial applications, 1-(4-aminophenyl)butan-1-one exemplifies how a seemingly simple organic molecule can hold keys to advancements in health and industry.

“The beauty of chemistry lies in its ability to reveal the secrets of nature through the lens of molecules such as 1-(4-aminophenyl)butan-1-one.”

Synonyms
4'-Aminobutyrophenone
1-Butanone, 1-(4-aminophenyl)-
1-(4-Aminophenyl)-1-butanone
BRN 2084800
DTXSID4061884
4-14-00-00166 (Beilstein Handbook Reference)
DTXCID0035407
cycsozsebpzgpc-uhfffaoysa-n
1688-71-7
1-(4-aminophenyl)butan-1-one
p-Aminobutyrophenone
BUTYROPHENONE, 4'-AMINO-
4''-Aminobutyrophenone
SCHEMBL2677865
1-(4-aminophenyl)-butan-1-one
1-Butanone,1-(4-aminophenyl)-
1-(4-amino-phenyl)-butan-1-one
1-(4-Aminophenyl)-1-butanone #
MFCD00017114
AKOS009158786
FA66363
FS-4840
CS-0206020