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4'-Aminoacetophenone

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Identification
Molecular formula
C8H9NO
CAS number
122-78-1
IUPAC name
1-(4-aminophenyl)ethanone
State
State

At room temperature, 4'-Aminoacetophenone is typically a solid. It is often found in its crystalline form and is stable under standard conditions of temperature and pressure.

Melting point (Celsius)
104.00
Melting point (Kelvin)
377.15
Boiling point (Celsius)
293.00
Boiling point (Kelvin)
566.15
General information
Molecular weight
135.17g/mol
Molar mass
135.1650g/mol
Density
1.1563g/cm3
Appearence

4'-Aminoacetophenone typically appears as a light yellow crystalline solid. Its crystalline nature is due to the orderly arrangement of molecules in the solid-state, and it usually has a distinct aromatic odor.

Comment on solubility

Solubility of 1-(4-aminophenyl)ethanone

1-(4-aminophenyl)ethanone, also known as para-aminophenylacetone, exhibits distinct solubility characteristics that are important for its applications in various domains. Understanding its solubility profile can enhance its usability in chemical reactions and formulations.

Key points regarding the solubility of 1-(4-aminophenyl)ethanone include:

  • Solvent Compatibility: This compound is generally soluble in organic solvents such as ethanol, acetone, and chloroform, which makes it suitable for integration into organic synthesis processes.
  • Water Solubility: The water solubility of 1-(4-aminophenyl)ethanone is relatively low due to its hydrophobic ethyl ketone structure, which can impede its dissolution in aqueous environments.
  • Temperature Dependence: Like many organic compounds, the solubility of 1-(4-aminophenyl)ethanone may increase with higher temperatures, facilitating its use in thermally-controlled reactions or processes.
  • pH Influence: The solubility can also be affected by pH; under moderate acidic conditions, the amine group may become protonated, potentially increasing the solubility in polar solvents.

In summary, while 1-(4-aminophenyl)ethanone demonstrates favorable solubility in organic solvents, its solubility in water remains limited, necessitating careful consideration in its application contexts. As with many organic compounds, understanding these solubility aspects can lead to more effective and efficient use in both laboratory and industrial settings.

Interesting facts

Interesting Facts about 1-(4-aminophenyl)ethanone

1-(4-aminophenyl)ethanone, also known as p-acetamidobenzene, is a compound that bridges organic chemistry and medicinal applications. Here are some intriguing aspects of this compound:

  • Structural Features: The compound features a phenyl ring substituted with an amino group and an acetyl group, which influences its chemical reactivity and properties.
  • Biological Significance: It is often explored in pharmacology for its potential roles in various biological systems. Its structure suggests it's a candidate for developing analgesic or anti-inflammatory agents, similar to acetaminophen.
  • Synthesis: 1-(4-aminophenyl)ethanone can be synthesized through acetylation of 4-aminophenol, showcasing the importance of such functional groups in organic synthesis.
  • Reactivity: The presence of both an amino group and a carbonyl group allows for interesting reactivity. It can participate in nucleophilic addition reactions due to the electrophilic nature of the carbonyl carbon.
  • Application in Dyes: This compound's unique structure also makes it an exciting precursor in the field of dyes and pigments, especially in the synthesis of various colorants.

Overall, the study of 1-(4-aminophenyl)ethanone offers insight into the intersection of organic chemistry and medicinal application. Researchers continue to explore its many potential uses, emphasizing the importance of understanding such compounds for innovative applications in health and industry.

Synonyms
4'-Aminoacetophenone
99-92-3
4-Aminoacetophenone
1-(4-Aminophenyl)ethanone
p-Aminoacetophenone
4-ACETYLANILINE
p-Acetylaniline
Ethanone, 1-(4-aminophenyl)-
p-Aminoacetylbenzene
1-(4-Aminophenyl)Ethan-1-One
Acetophenone, 4'-amino-
Acetophenone, p-amino-
Acetophenone, 4-amino-
p-Aminoacetofenonu
p-amino acetophenone
USAF EK-631
MFCD00007896
CCRIS 5061
1-acetyl-4-aminobenzene
HSDB 2711
NSC 3242
EINECS 202-801-2
1-(4-Aminophenyl)-ethanone
UNII-1S58KH902I
BRN 0471493
AI3-01092
NSC-3242
4-AMINO-ACETOPHENON
4-ACETYLANILINE [HSDB]
DTXSID6052669
1S58KH902I
4-14-00-00100 (Beilstein Handbook Reference)
p-Aminoacetofenonu [Polish]
4'-aminoacetophenon
4-Acetylaniline; p-Aminoacetophenone; p-Aminoacetylbenzene
pAcetylaniline
4-acetylanilin
pAminoacetofenonu
pAminoacetophenone
p-aminoacetophenon
pAminoacetylbenzene
4'aminoacetophenone
p-amino-acetophenone
Acetophenone, pamino
4-acetyl phenylamine
4-amino acetophenone
para-aminoacetophenone
Acetophenone, 4amino
aniline, 4-acetyl-
para-amino acetophenone
4'-Amino acetophenone
1(4Aminophenyl)ethanone
Ethanone, 1(4aminophenyl)
WLN: ZR DV1
1-(4-aminophenyl) ethanone
4'-Aminoacetophenone, 99%
SCHEMBL223335
1-(4-amino-phenyl)-ethanone
CHEMBL3278329
DTXCID7031242
SCHEMBL12918413
NSC3242
BCP30575
STR00944
STL181959
AKOS000119076
CS-W009534
FA17680
HY-W008818
PS-4587
SB75393
BP-13068
SY011145
A0251
NS00009372
4 inverted exclamation mark -Aminoacetophenone
EN300-17971
F11286
p-Aminoacetophenone; 1-(4-Aminophenyl)-ethanone
AC-907/25014209
AE-641/02305020
1-(4-Aminophenyl)ethanone;1-Acetyl-4-aminobenzene
Q27252822
Z57127377
F2146-0311
CLENBUTEROL HYDROCHLORIDE IMPURITY D [EP IMPURITY]
4'-Aminoacetophenone, for spectrophotometric det. of Ce, Pd, >=98.0% (NT)
4'-Aminoacetophenone, Pharmaceutical Secondary Standard; Certified Reference Material
1-(4-Aminophenyl)ethanone;p-Aminoacetophenone; 1-Acetyl-4-aminobenzene; 4-Acetylaniline; 4-Acetylphenylamine;Clenbuterol Impurity D