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BRL 49653

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Identification
Molecular formula
C13H13BrN6
CAS number
130806-84-5
IUPAC name
1-(4-bromophenyl)-2-(4,6-dimethylpyrimidin-2-yl)guanidine
State
State

The compound is found in a solid state at room temperature. It typically forms fine, crystalline powders.

Melting point (Celsius)
218.00
Melting point (Kelvin)
491.15
Boiling point (Celsius)
360.70
Boiling point (Kelvin)
633.90
General information
Molecular weight
375.19g/mol
Molar mass
375.1910g/mol
Density
1.3885g/cm3
Appearence

The compound typically appears as a crystalline solid with a slight yellowish tint. It is not hygroscopic and is fairly stable under normal conditions.

Comment on solubility

Solubility of 1-(4-bromophenyl)-2-(4,6-dimethylpyrimidin-2-yl)guanidine

The solubility of 1-(4-bromophenyl)-2-(4,6-dimethylpyrimidin-2-yl)guanidine can be influenced by various factors including its molecular structure, polarity, and interactions with solvents. Understanding solubility is crucial for applications in drug formulation, catalysis, and chemical synthesis. Here are some key points to consider:

  • Polarity: Due to the presence of polar functional groups such as guanidine, this compound may exhibit variable solubility in polar solvents like water.
  • Hydrophobic Effects: The 4-bromophenyl and 4,6-dimethylpyrimidin-2-yl moieties may impart some hydrophobic characteristics, potentially reducing solubility in aqueous environments.
  • Temperature Dependence: As with many organic compounds, solubility could increase with temperature, making it essential to consider the solvents' thermal properties.
  • pH Sensitivity: The guanidine group may be sensitive to pH changes, leading to solubility variations based on the acidity or basicity of the medium.

In summary, while the detailed solubility profile of 1-(4-bromophenyl)-2-(4,6-dimethylpyrimidin-2-yl)guanidine can be complex, understanding the interplay of polarity, hydrophobic effects, temperature, and pH is crucial for predicting its behavior in various contexts. A comprehensive solubility analysis should incorporate experimental data for precise applications.

Interesting facts

Exploring 1-(4-bromophenyl)-2-(4,6-dimethylpyrimidin-2-yl)guanidine

The compound 1-(4-bromophenyl)-2-(4,6-dimethylpyrimidin-2-yl)guanidine is a fascinating substance within the realm of medicinal chemistry. Known for its unique structural features and versatile applications, it plays a critical role in various chemical pathways.

Key Characteristics

  • Pharmacological Relevance: This compound is often analyzed for its potential as a pharmacological agent. Its intricate design allows for interaction with biological targets, making it a significant subject of study in drug development.
  • Structural Insights: The addition of bromine in the phenyl group enhances the compound's reactivity, providing opportunities for diverse chemical transformations. The pyrimidine moiety contributes additional properties, such as the ability to form hydrogen bonds.
  • Mechanism of Action: Researchers are keenly interested in how this compound interacts at the molecular level, especially regarding its binding affinity and selectivity towards specific receptors.

Applications and Research

This compound's ability to influence biological systems has made it a prime candidate for investigational studies aimed at understanding complex diseases. Some interesting areas of focus include:

  • Investigating its antitumor properties, particularly in relation to inhibiting cancer cell proliferation.
  • Exploring its role in modulating neurotransmitter systems, which could provide insights into treating neurological disorders.
  • Evaluating its effectiveness as a biochemical tool for studying enzyme activity and function.

"The beauty of chemical compounds lies not only in their structure but in their potential to shape our understanding of complex biological systems."

In summary, 1-(4-bromophenyl)-2-(4,6-dimethylpyrimidin-2-yl)guanidine stands out as a compound of considerable interest, bridging the gap between synthetic chemistry and its applications in pharmacology. The ongoing research surrounding this compound promises to uncover even more intriguing possibilities.

Synonyms
Cambridge id 5804741
N-(4-bromophenyl)-N'-(4,6-dimethylpyrimidin-2-yl)guanidine
1-(4-bromophenyl)-3-(4,6-dimethylpyrimidin-2-yl)guanidine
SCHEMBL5923509
DTXSID90936243
H32193