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1-(4-chloro-1H-indol-3-yl)butan-2-amine

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Identification
Molecular formula
C12H15ClN2
CAS number
91393-49-6
IUPAC name
1-(4-chloro-1H-indol-3-yl)butan-2-amine
State
State

The compound is typically found as a solid at room temperature.

Melting point (Celsius)
128.00
Melting point (Kelvin)
401.15
Boiling point (Celsius)
330.00
Boiling point (Kelvin)
603.15
General information
Molecular weight
220.71g/mol
Molar mass
220.7120g/mol
Density
1.2300g/cm3
Appearence

1-(4-chloro-1H-indol-3-yl)butan-2-amine appears as a crystalline solid. The crystals are typically white to off-white in color.

Comment on solubility

Solubility of 1-(4-chloro-1H-indol-3-yl)butan-2-amine

1-(4-chloro-1H-indol-3-yl)butan-2-amine is an interesting compound with unique solubility characteristics. Solubility can depend on several factors, including polarity, molecular structure, and the presence of functional groups. Here are key points regarding its solubility:

  • Polarity: The presence of the chlorine atom and the indole ring indicate a mix of polar and nonpolar characteristics, suggesting moderate solubility in various solvents.
  • Solvent Compatibility: This compound is likely to be soluble in organic solvents such as ethanol and dichloromethane, while exhibiting limited solubility in water due to the hydrophobic indole structure.
  • pH Influence: The amine group may become protonated under acidic conditions, enhancing its solubility in aqueous solutions, particularly in stronger acids.
  • Temperature Factors: A rise in temperature could facilitate solubility, as increased kinetic energy often leads to improved dissolution rates.

In summary, while 1-(4-chloro-1H-indol-3-yl)butan-2-amine presents itself as moderately soluble in organic solvents, its solubility can be influenced by external conditions such as pH and temperature. Understanding these factors is crucial for practical applications in chemical formulations.

Interesting facts

Interesting Facts About 1-(4-chloro-1H-indol-3-yl)butan-2-amine

1-(4-chloro-1H-indol-3-yl)butan-2-amine, commonly referred to in various research circles, showcases the fascinating interplay between chemistry and biological activity. Here are some engaging points about this intriguing compound:

  • Indole Derivative: This compound is an indole derivative, a structure that often participates in various biological processes, making it crucial in pharmacology and medicinal chemistry.
  • Biological Significance: Compounds with indole structures are known for their roles in the central nervous system and are often studied for their potential therapeutic effects, including antidepressant and antipsychotic properties.
  • Chlorination Impact: The incorporation of chlorine atoms into organic compounds can significantly alter their chemical behavior, affecting factors such as solubility and reactivity. This chlorine substituent in 1-(4-chloro-1H-indol-3-yl)butan-2-amine can enhance its biological activity.
  • Synthetic Pathways: The synthesis of this compound involves various interesting synthetic pathways, challenging chemists to explore new methodologies that contribute to greater efficiency and sustainability.
  • Research Focus: The compound has attracted attention in scientific research, particularly in the field of drug design, where understanding its interaction with biological pathways is of utmost interest.

In conclusion, 1-(4-chloro-1H-indol-3-yl)butan-2-amine is not just another chemical entity; it represents a window into the world of bioactive molecules. As researchers continue to explore its properties, the compound stands at the forefront of innovation in medicinal chemistry.

Synonyms
3-(2-Aminobutyl)-4-chloroindole
715-47-9
1-(4-chloro-1H-indol-3-yl)butan-2-amine
BRN 0396163
4-Chloro-3-(alpha-ethylaminoethyl) indole
INDOLE, 3-(2-AMINOBUTYL)-4-CHLORO-
5-22-10-00178 (Beilstein Handbook Reference)
DTXSID90991938