Skip to main content

4-Chloro-α-methyltryptamine hydrochloride

ADVERTISEMENT
Identification
Molecular formula
C12H16ClN2 · HCl
CAS number
69457-67-6
IUPAC name
1-[(4-chloro-1H-indol-3-yl)methyl]propylammonium;chloride
State
State

The compound exists as a solid at room temperature, specifically in its crystalline hydrochloride form.

Melting point (Celsius)
160.00
Melting point (Kelvin)
433.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
229.13g/mol
Molar mass
229.1330g/mol
Density
1.2000g/cm3
Appearence

The compound appears as a white to off-white crystalline solid, typically forming fine powders or small crystals. It is often handled in the form of its hydrochloride salt to enhance solubility.

Comment on solubility

Solubility of 1-[(4-chloro-1H-indol-3-yl)methyl]propylammonium Chloride

The solubility of 1-[(4-chloro-1H-indol-3-yl)methyl]propylammonium chloride can be characterized by several important factors:

  • Highly water-soluble: The presence of the ammonium group suggests a tendency for the compound to dissolve readily in water due to ion-dipole interactions.
  • Influence of Chloride Ion: The chloride ion (Cl-) enhances solubility by stabilizing the ion pair in aqueous solutions.
  • Temperature Dependence: Solubility may increase with temperature, allowing for greater interaction with the solvent molecules.
  • pH Sensitivity: The solubility can vary with changes in pH, particularly if it affects the protonation state of the ammonium group.

In conclusion, 1-[(4-chloro-1H-indol-3-yl)methyl]propylammonium chloride is expected to be considerably soluble in polar solvents such as water due to its ionic nature, which can facilitate enhanced interaction with solvent particles. This solubility profile is critical for its applications in pharmacology and biochemistry.

Interesting facts

Interesting Facts about 1-[(4-chloro-1H-indol-3-yl)methyl]propylammonium Chloride

This compound, known as 1-[(4-chloro-1H-indol-3-yl)methyl]propylammonium chloride, is a fascinating example of a quaternary ammonium salt, which is often utilized in various fields of research and applications due to its unique properties. Here are some interesting insights:

  • Biological Significance: The indole structure present in this compound is a fundamental building block in many biologically active compounds. Indole derivatives are known for their roles in medicine, including applications as antidepressants and anti-cancer agents.
  • Quaternization: The quaternization of amines, such as in this compound, leads to increased stability and solubility in ionic forms. This property makes quaternary ammonium compounds valuable in the development of pharmaceuticals and surfactants.
  • Chloride Counterion: The presence of the chloride ion enhances the molecule's ability to dissociate in solution, promoting its role as an effective ionic compound in various chemical reactions.
  • Research Applications: Compounds like this one are often used in studies related to ion transport in biological membranes, contributing to our understanding of cellular processes and signaling pathways.
  • Chemical Flexibility: The varying substituents on the indole ring allow for extensive modification, giving researchers the ability to synthesize a plethora of derivatives with tailored properties for specific applications.

In conclusion, 1-[(4-chloro-1H-indol-3-yl)methyl]propylammonium chloride stands out not just for its functional groups, but also for its potential contributions to the field of medicinal chemistry and beyond. As we delve deeper into these compounds, we pave the way towards advancing our understanding of complex biological systems and creating new therapeutic strategies.

Synonyms
3-(2-Aminobutyl)-4-chloroindole hydrochloride
1206-72-0
INDOLE, 3-(2-AMINOBUTYL)-4-CHLORO-, HYDROCHLORIDE