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4-Chloroamphetamine

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Identification
Molecular formula
C11H14ClN
CAS number
2235-64-1
IUPAC name
1-(4-chloro-1H-indol-3-yl)propan-2-amine
State
State

At room temperature, 4-Chloroamphetamine is typically found as a solid.

Melting point (Celsius)
121.00
Melting point (Kelvin)
394.20
Boiling point (Celsius)
266.50
Boiling point (Kelvin)
539.70
General information
Molecular weight
183.65g/mol
Molar mass
183.6530g/mol
Density
1.0900g/cm3
Appearence

The compound is typically a crystalline solid that may appear as a white powder, though samples may have varied appearance based on purity and form.

Comment on solubility

Solubility of 1-(4-chloro-1H-indol-3-yl)propan-2-amine

The solubility of 1-(4-chloro-1H-indol-3-yl)propan-2-amine can be quite intricate due to its chemical structure. Here are some key points to consider:

  • Solvent Dependence: The solubility of this compound largely depends on the solvent used. It tends to be more soluble in polar solvents like water and ethanol due to the presence of amine functional groups, which can engage in hydrogen bonding.
  • Temperature Influence: As with many compounds, temperature plays a significant role in solubility. Increased temperatures typically enhance solubility, allowing for greater interaction between the solute and solvent molecules.
  • pH Factors: The solubility may also be affected by the pH of the solution. In acidic environments, the amine group can be protonated, increasing the solubility in water.

Overall, while 1-(4-chloro-1H-indol-3-yl)propan-2-amine may present moderate solubility in various solvents, the specific conditions such as solvent type, temperature, and pH can have a significant impact on its overall solubility profile.

Interesting facts

Interesting Facts about 1-(4-chloro-1H-indol-3-yl)propan-2-amine

1-(4-chloro-1H-indol-3-yl)propan-2-amine, commonly referred to as a derivative of indole, has garnered interest in various fields of research, highlighting its potential applications.

Key Insights:

  • Biochemical Significance: This compound shows promise as a modulator of serotonin receptors, suggesting potential therapeutic effects in the treatment of mood disorders.
  • Pharmaceutical Potential: Due to its structural similarities to important pharmaceutical agents, research continues into its role in drug development, particularly in psychiatry and neuropharmacology.
  • Research Applications: Studies have indicated that compounds in its class can possess anti-inflammatory and analgesic properties, making them interesting candidates for pain management therapies.
  • Structure-Activity Relationship (SAR): The presence of a chlorine atom at the para position of the indole ring significantly influences its biological activity, making SAR studies a focal point for understanding how modifications can enhance efficacy.

According to leading researchers, “The ability to fine-tune molecular structures can lead to breakthroughs in treatment options for several neurological conditions.” This underscores the importance of compounds like 1-(4-chloro-1H-indol-3-yl)propan-2-amine in advancing medicinal chemistry.

On a practical note, careful synthesis and characterization of this compound are imperative for exploring its full potential in the medical field, and ongoing studies may reveal even more about its desirable traits and functionalities.

Synonyms
711-54-6
1-(4-chloro-1H-indol-3-yl)propan-2-amine
4-Chloro-3-(alpha-methylaminoethyl) indole
BRN 0475950
4-Chloro-3-(2-amino-1-propyl)indole
INDOLE, 4-CHLORO-3-(2-AMINO-1-PROPYL)-
Indol, 3-(2-aminpropyl)-4-chloro-
DTXSID10991415
AKOS022212105