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Clotrimazole hydrochloride

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Identification
Molecular formula
C11H8Cl2N2O
CAS number
7080-44-0
IUPAC name
1-(4-chlorophenyl)-2-(1H-imidazol-1-ium-1-yl)ethanone;chloride
State
State

Clotrimazole hydrochloride is typically in a solid state at room temperature. This compound is stable under normal conditions and useful in medical applications due to its antifungal activity.

Melting point (Celsius)
142.00
Melting point (Kelvin)
415.15
Boiling point (Celsius)
325.00
Boiling point (Kelvin)
598.15
General information
Molecular weight
344.19g/mol
Molar mass
344.2810g/mol
Density
1.3290g/cm3
Appearence

Clotrimazole hydrochloride typically appears as a white to off-white crystalline powder. It is often used in pharmaceutical formulations because of its antifungal properties.

Comment on solubility

Solubility of 1-(4-chlorophenyl)-2-(1H-imidazol-1-ium-1-yl)ethanone;chloride

The solubility of 1-(4-chlorophenyl)-2-(1H-imidazol-1-ium-1-yl)ethanone;chloride exhibits some interesting characteristics due to its structural components. Key factors influencing the solubility include:

  • Polarity: The presence of the imidazolium moiety enhances the polarity of the compound, which generally favors solubility in polar solvents.
  • Chloride Ion: As a chloride salt, it is expected to dissolve well in water, given that chloride ions are often soluble in aqueous solutions.
  • Hydrogen Bonding: The potential for hydrogen bonding due to functional groups can also aid in solubility, particularly in alcohols and other hydrogen-bonding solvents.

In practice, this compound is anticipated to be soluble in a variety of polar solvents such as water and methanol, although precise solubility values would depend on factors such as temperature and pH. Furthermore, the combination of hydrophilic and hydrophobic areas in its structure suggests that caution should be taken when predicting solubility in organic solvents.

In summary, while solubility should generally be favorable in polar environments, experimental validation is essential for comprehensive understanding.

Interesting facts

Interesting Facts about 1-(4-chlorophenyl)-2-(1H-imidazol-1-ium-1-yl)ethanone; chloride

This compound stands out due to its unique structure and potential applications in various fields, particularly in medicinal chemistry. Here are some engaging facts:

  • Pharmacological Significance: Compounds containing imidazole rings, such as this one, have been widely researched for their biological activity. They often exhibit antimicrobial, antifungal, and anti-inflammatory properties, making them interesting candidates for drug development.
  • Chlorine's Role: The presence of the Cl atom in the para position of a phenyl group can significantly alter the compound's reactivity and biological characteristics, enhancing its interaction with biological targets.
  • Structure-Activity Relationship: The structural features of 1-(4-chlorophenyl)-2-(1H-imidazol-1-ium-1-yl)ethanone; chloride provide a great example of how minor modifications can influence the pharmacological effects of a compound. Understanding these relationships is vital in drug design.
  • Historical Uses: Imidazole derivatives have a rich history in medicinal applications. Scientists have leveraged their unique properties for creating antifungal therapies, among other treatments.
  • Research Opportunities: Ongoing studies into this class of compounds continue to unveil new potentials, particularly in targeting resistant strains of bacteria and fungi. The exploration of this compound could yield promising results in addressing current healthcare challenges.

In summary, 1-(4-chlorophenyl)-2-(1H-imidazol-1-ium-1-yl)ethanone; chloride, through its intriguing structural elements and biological implications, is a compound worth further exploration. As a scientist or chemistry student, understanding the implications of such compounds can lead to exciting breakthroughs in the field of medicinal chemistry.

Synonyms
N-(4-Chlorophenacyl)imidazole hydrochloride
24169-70-8
ACETOPHENONE, 4'-CHLORO-2-(1-IMIDAZOLYL)-, HYDROCHLORIDE