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Lidocaine

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Identification
Molecular formula
C14H22ClN3O
CAS number
137-58-6
IUPAC name
1-(4-chlorophenyl)-2-[3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)propyl-methyl-amino]ethanone
State
State

At room temperature, Lidocaine is generally found as a solid. However, it can also be formulated as a liquid solution for injections.

Melting point (Celsius)
66.00
Melting point (Kelvin)
339.15
Boiling point (Celsius)
350.00
Boiling point (Kelvin)
623.15
General information
Molecular weight
234.34g/mol
Molar mass
234.3360g/mol
Density
1.2400g/cm3
Appearence

Lidocaine typically appears as a white crystalline powder or a clear, colorless liquid when in its injectable form. The solid form is typically used for topical applications and as an ingredient in ointments and gels.

Comment on solubility

Solubility of 1-(4-chlorophenyl)-2-[3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)propyl-methyl-amino]ethanone

The solubility of the compound with the formula C14H22ClN3O can be influenced by several key factors. Understanding these can shed light on its behavior in various solvents:

  • Polarity: This compound has polar functional groups due to the presence of nitrogen and oxygen, which typically increases solubility in polar solvents such as water.
  • Log P: The partition coefficient (Log P) is crucial; higher values indicate better solubility in non-polar solvents, while lower values favor polar solvents. The structure suggests a possible moderate partition coefficient.
  • Hydrogen Bonding: The capability to form hydrogen bonds can enhance solubility in protic solvents. This compound may exhibit such interactions due to the presence of amino and carbonyl groups.
  • Temperature Effects: Solubility often increases with temperature, so assessing how this compound behaves at varying temperatures is vital for practical applications.

In summary, while the solubility of 1-(4-chlorophenyl)-2-[3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)propyl-methyl-amino]ethanone is likely to be moderate in polar solvents, specific experimental data is essential for precise characterization. Always consider how the molecular structure interplays with the solvent environment to make informed predictions about solubility.

Interesting facts

Interesting Facts About 1-(4-chlorophenyl)-2-[3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)propyl-methyl-amino]ethanone

This compound, with its intricate structure and potential applications in medicinal chemistry, provides a fascinating glimpse into the world of pharmaceuticals. Here are some key points to consider:

  • Complex Structure: The structure of this compound illustrates a blend of various chemical functionalities, including an aromatic ring system, a carbonyl group, and a secondary amine.
  • Potential Therapeutic Applications: Compounds similar to this one often serve as precursor molecules in the development of medications aimed at treating neurological or psychological conditions, reflecting the importance of structure-activity relationships in drug design.
  • Synthetic Interest: The synthetic pathways leading to such complex molecules are of particular interest in organic chemistry. Researchers often explore various methods to enhance yield and selectivity during synthesis.
  • Chlorine Substitution: The presence of a chlorine atom adds intriguing properties to the compound, often enhancing biological activity while also affecting lipophilicity and overall pharmacokinetics.
  • Stereochemistry and Activity: The spatial arrangement of atoms in this compound may significantly influence its biological activity. With proper stereochemical analysis, scientists can tailor compounds to achieve desired therapeutic effects.

In summation, this compound is not just a series of atoms and bonds; it represents a gateway to understanding complex biological interactions and the synthesis of pharmaceuticals. As researchers continue to explore its properties, this compound may unlock new possibilities in the realm of medicinal chemistry.

Synonyms
LOFEPRAMINE
23047-25-8
Lopramine
Amplit
Leo 640
Lofepramina
Lofepraminum
Gamanil
Lomont
Lofepramine [INN:BAN]
Lofepraminum [INN-Latin]
Lofepramina [INN-Spanish]
OCA4JT7PAW
UNII-OCA4JT7PAW
HSDB 7184
4'-Chlor-2-((3-(10,11-dihydro-5H-dibenz(b,f)azepin-5-yl)propyl)methylamino)acetophenon
EINECS 245-396-8
Lofepramine (INN)
DB 2182
Ethanone, 1-(4-chlorophenyl)-2-[[3-(10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propyl]methylamino]-
Gamanil (Salt/Mix)
Gamonil (Salt/Mix)
Timelit (Salt/Mix)
Tymelyt (Salt/Mix)
CHEBI:47782
LOFEPRAMINE [MI]
Ethanone, 1-(4-chlorophenyl)-2-((3-(10,11-dihydro-5H-dibenz(b,f)azepin-5-yl)propyl)methylamino)-
LOFEPRAMINE [INN]
LOFEPRAMINE [JAN]
LOFEPRAMINE [HSDB]
LOFEPRAMINE [WHO-DD]
1-(4-chlorophenyl)-2-[3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)propyl-methylamino]ethanone
DTXSID2023220
Lofepramin hydrochloride (Salt/Mix)
Acetophenone, 4'-chloro-2-((3-(10,11-dihydro-5H-dibenz(b,f)azepin5-yl)propyl)methylamino)-
1-(4-Chlorophenyl)-2-((3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)propyl)(methyl)amino)ethan-1-one
1-(4-chlorophenyl)-2-{[3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)propyl](methyl)amino}ethanone
Amplit (TN)
Lofepraminum (INN-Latin)
Lofepramina (INN-Spanish)
4'-chloro-2-((3-(10,11-dihydro-5H-dibenz(b,f)azepin5-yl)propyl)methylamino)acetophenone
4'-Chloro-2-[[3-(10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propyl]methylamino]acetophenone
1-(4-chlorophenyl)-2-{[3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)propyl]methylamino}ethanone
4'-CHLORO-2-((3-(10,11-DIHYDRO-5H-DIBENZ(B,F)AZEPIN-5-YL)PROPYL)METHYLAMINO)ACETOPHENONE
N-Methyl-N(4-chlorobenzoylmethyl)-3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)propylamine hydrochloride
NCGC00166397-02
1-(4-chlorophenyl)-2-((3-(10,11-dihydro-5H-dibenzo(b,f)azepin-5-yl)propyl)(methyl)amino)ethanone
1-(4-chlorophenyl)-2-((3-(10,11-dihydro-5H-dibenzo(b,f)azepin-5-yl)propyl)methylamino)ethanone
1-(4-chlorophenyl)-2-(3-(5,6-dihydrobenzo(b)(1)benzazepin-11-yl)propyl-methylamino)ethanone
N-Methyl-N(4-chlorobenzoylmethyl)-3-(10,11-dihydro-5H-dibenzo(b,f)azepin-5-yl)propylamine hydrochloride
4'-Chloro-2-
Gamanil (United Kingdom)
1-(4-Chlorophenyl)-2-
1-(4-Chlorophenyl)-2-[[3-(10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propyl]methylamino]ethanone
SCHEMBL35028
CHEMBL87708
DTXCID303220
GTPL7551
Lofepramine - Bio-X trade mark
BDBM82437
N06AA07
HMS3269O19
HMS3413F21
HMS3677F21
HMS3715L16
NSC_3947
AKOS024457158
CCG-221257
DB13411
FL24917
NCGC00166397-01
NCGC00166397-03
BL164630
DA-54990
HY-12390
US8629135, SW-06
CAS_23047-25-8
CS-0011244
NS00004691
D08140
G12703
AB00698521-05
L000944
Q368941
BRD-K82147103-001-02-7
BRD-K82147103-003-05-6
Z2681890859
N-methyl-N-(4-chlorobenzoylmethyl)-3-(10,11-dihydro-5H-dibenzo
1-(4-Chlorophenyl)-2-[[3-(10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propyl]methylamino]ethanone;4'-Chloro-2-[[3-(10,11-dihydro-5H-dibe nz[b,f]azepin-5-yl)propyl-methylamino]acetophenone
1-(4-Chlorophenyl)-2-[[3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)propyl](methyl)amino]ethanone #
245-396-8