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Clonazepam hydrochloride

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Identification
Molecular formula
C15H10ClNO2 • HCl
CAS number
1622-61-3
IUPAC name
1-(4-chlorophenyl)-2-[3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)propyl-methyl-amino]ethanone;hydrochloride
State
State

At room temperature, Clonazepam hydrochloride is in a solid state, appearing as a crystalline powder.

Melting point (Celsius)
235.00
Melting point (Kelvin)
508.15
Boiling point (Celsius)
280.00
Boiling point (Kelvin)
553.15
General information
Molecular weight
315.69g/mol
Molar mass
315.2000g/mol
Density
1.2300g/cm3
Appearence

Clonazepam hydrochloride is typically observed as a white to off-white crystalline powder.

Comment on solubility

Solubility of 1-(4-chlorophenyl)-2-[3-(5,6-dihydrobenzob[1]benzazepin-11-yl)propyl-methyl-amino]ethanone; hydrochloride

The solubility of 1-(4-chlorophenyl)-2-[3-(5,6-dihydrobenzob[1]benzazepin-11-yl)propyl-methyl-amino]ethanone; hydrochloride can be quite complex, influenced by factors such as pH, temperature, and the presence of other solutes. Here are some key points regarding its solubility:

  • Hydrochloride Salt Form: The presence of the hydrochloride salt typically increases the solubility of the compound in aqueous solutions, compared to its free base form.
  • Polar and Non-Polar Attributes: The compound contains both polar and non-polar characteristics, which may lead to differential solubility in various solvents.
  • pH Dependence: The solubility may be significantly influenced by the pH of the solution, with potential increases in solubility observed in acidic conditions.
  • Temperature Effects: Higher temperatures often facilitate greater solubility, making them essential in practical applications.
  • Solvent Choice: Organic solvents like methanol or ethanol might show varying solubility profiles, providing needed flexibility depending on the application.

In conclusion, the solubility of this complex compound showcases an intriguing interplay of chemical structure and environmental conditions, significantly affecting its behavior in different media. As with many biological compounds, understanding these solubility dynamics is crucial for effective application in medicinal chemistry and pharmacology.

Interesting facts

In-Depth Look at 1-(4-Chlorophenyl)-2-[3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)propyl-methyl-amino]ethanone; Hydrochloride

This compound is a fascinating member of the expanding world of pharmaceuticals, particularly in the realm of central nervous system agents. Its structure suggests intriguing pharmacological potential, which scientists are eager to explore.

Key Features

  • Complex Structure: The compound contains a unique blend of a benzazepine core and a 4-chlorophenyl ring. This complex architecture is indicative of compounds with nuanced interactions at biological targets.
  • Psychotropic Potential: Given its structural elements, it may possess properties linked to mood modulation, potentially impacting serotonin or dopamine pathways, which could contribute to treatments for various neuropsychiatric disorders.
  • Hydrochloride Salt Form: The hydrochloride salt form can improve the compound's solubility and stability, which are critical factors for excellent bioavailability in therapeutic applications.

As part of a growing class of novel drugs, compounds like this one highlight the importance of multi-targeting approaches in drug design. By engaging several biological mechanisms, they potentially offer more effective treatment options with fewer side effects.

Research Implications

Researchers are currently exploring the potential benefits and risks associated with this compound. Investigating its behavior in biological systems could reveal:

  • How the **dihydrobenzo[b][1]benzazepin** moiety contributes to its efficacy.
  • Potential side effects arising from its pharmacological activity.
  • Insights into how similar compounds can be synthesized for enhanced therapeutic profiles.

In summary, 1-(4-Chlorophenyl)-2-[3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)propyl-methyl-amino]ethanone; hydrochloride is not just an ordinary chemical compound; it holds the promise of improving human health through innovative therapeutic pathways. As we venture further into its study, we may uncover new horizons in medical chemistry.

Synonyms
lofepramine hydrochloride
26786-32-3
Lofepramine HCl
Clopepramine hydrochloride
Amplit
WHR-2908A
4'-Chloro-2-((3-(10,11-dihydro-5H-dibenz(b,f)azepin-5-yl)propyl)methylamino)acetophenone monohydrochloride
DTXSID9047833
CHEBI:31780
Z24K96F991
DTXCID5027809
Ethanone, 1-(4-chlorophenyl)-2-((3-(10,11-dihydro-5H-dibenz(b,f)azepin-5-yl)propyl)methylamino)-, monohydrochloride
RefChem:800018
Hydrochloride, Lofepramine
248-002-2
4'-Chloro-2-((3-(10,11-Dihydro-5H-Dibenz(b, f)azepin-5-yl)Propyl)Methylamino)acetophenone Monohydrochloride
Ethanone, 1-(4-Chlorophenyl)-2-((3-(10,11-Dihydro-5H-Dibenz(b, f)azepin-5-yl)Propyl)Methylamino)-, Monohydrochloride
Ethanone, 1-(4-chlorophenyl)-2-((3-(10,11-dihydro-5H-dibenz(b,f)azepin-5-yl)propyl)methylamino)-, hydrochloride (1:1)
LOFEPRAMINEHYDROCHLORIDE
Lofepramine (hydrochloride)
Lopramine (hydrochloride)
Gamanil
N-(4-Chlorobenzoylmethyl)-3-(10,11-dihydro-5h-dibenz[b,f]azepin-5-yl)-n-methylpropylamine hydrochloride
1-(4-Chlorophenyl)-2-((3-(10,11-dihydro-5H-dibenz(b,f)azepin-5-yl)propyl)methylamino)ethan-1-one monohydrochloride
1-(4-chlorophenyl)-2-[3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)propyl-methylamino]ethanone;hydrochloride
Iopramine hydrochloride
Leo 640 hydrochloride
CAS-26786-32-3
WHR 2908A
NCGC00166397-02
EINECS 248-002-2
Lofepramine hydrochloride [USAN:JAN]
DB-2182
UNII-Z24K96F991
Amplit (TN)
5H-Dibenz(b,f)azepine, 5-(3-((p-chlorobenzoylmethyl)-N-methylamino)propyl)-, hydrochloride
N-Methyl-N-(4'-chlorophenacyl)-3-(10,11-dihydro-5H-dibenzo(b,f)azepin-5-yl)propylamine HCl
MLS001423956
SCHEMBL120115
orb1703133
CHEMBL2106638
SCHEMBL29357807
ZWZIQPOLMDPIQM-UHFFFAOYSA-N
BCP29730
EX-A3769
Tox21_112414
HY-12390A
MFCD00941486
Lofepramine hydrochloride (JAN/USAN)
LOFEPRAMINE HYDROCHLORIDE [MI]
AKOS015994728
Tox21_112414_1
CCG-100861
KS-1301
LOFEPRAMINE HYDROCHLORIDE [JAN]
NC00111
LOFEPRAMINE HYDROCHLORIDE [USAN]
LOFEPRAMINE HYDROCHLORIDE [MART.]
NCGC00166397-04
Acetophenone, 4'-chloro-2-((3-(10,11-dihydro-5H-dibenz(b,f)azepin-5-yl)propyl)methylamino)-, hydrochloride
LOFEPRAMINE HYDROCHLORIDE [WHO-DD]
SMR000469292
DB-047016
NS00084021
D01285
Q27114684
Lofepramine HCl;DB-2182; WHR 2908A; WHR-2908A;Hydrochloride, Lofepramine
1-(4-chlorophenyl)-2-{[3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)propyl](methyl)amino}ethanone hydrochloride
1-(4-chlorophenyl)-2-{[3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)propyl]methylamino}ethanone hydrochloride
4'-CHLORO-2-((3-(10,11-DIHYDRO-5H-DIBENZ(B,F)AZEPIN-5-YL)PROPYL)METHYLAMINO)ACETOPHENONE HYDROCHLORIDE
Lofepramine hydrochloride, 1.0 mg/mL in methanol (with 1% 1 M HCL; as free base), certified reference material