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Chloramphenicol

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Identification
Molecular formula
C11H12Cl2N2O5
CAS number
56-75-7
IUPAC name
1-(4-chlorophenyl)-2-[4-(2,2-dichloroacetyl)anilino]-2-hydroxy-ethanone
State
State

Chloramphenicol is typically found in a solid state at room temperature.

Melting point (Celsius)
150.00
Melting point (Kelvin)
423.15
Boiling point (Celsius)
185.00
Boiling point (Kelvin)
458.15
General information
Molecular weight
323.13g/mol
Molar mass
323.1330g/mol
Density
1.6500g/cm3
Appearence

Chloramphenicol commonly appears as a white to yellowish-white, fine, crystalline powder. It is odorless and has a characteristic bitter taste.

Comment on solubility

Solubility of 1-(4-chlorophenyl)-2-[4-(2,2-dichloroacetyl)anilino]-2-hydroxy-ethanone

The solubility of 1-(4-chlorophenyl)-2-[4-(2,2-dichloroacetyl)anilino]-2-hydroxy-ethanone can be influenced by a variety of factors, making it quite intriguing. Understanding its solubility behavior is essential for applications ranging from pharmaceuticals to chemical synthesis.

Key Factors Influencing Solubility:

  • Polarity: Compounds with polar functional groups tend to be more soluble in polar solvents, while non-polar substances dissolve better in non-polar solvents.
  • Hydrogen Bonding: The presence of hydroxyl (-OH) and amine (-NH) groups can enhance solubility through hydrogen bonding interactions with solvents.
  • Molecular Size: Larger molecules may have decreased solubility due to steric hindrance that affects interactions with solvent molecules.

In practical terms, the solubility of this compound may vary in common solvents as follows:

  • Water: Often limited solubility due to hydrophobic regions.
  • Alcohols: Possible increased solubility due to hydrogen bonding with the -OH group.
  • Organic Solvents: May exhibit higher solubility depending on the solvent's polarity.

Overall, it is crucial to examine solubility data and conduct empirical testing to determine the most suitable solvents for this compound. As it stands, the intricate balance of molecular characteristics and solvent interactions will ultimately dictate the solubility performance.

Interesting facts

Interesting Facts about 1-(4-chlorophenyl)-2-[4-(2,2-dichloroacetyl)anilino]-2-hydroxy-ethanone

This compound, known for its complex structure and unique functional groups, is a fascinating subject of study in the field of organic chemistry. Here are some interesting aspects of this compound:

  • Pharmaceutical Applications: The presence of the anilino and hydroxy groups may suggest potential usage in medicinal chemistry, as these functionalities are often associated with bioactivity and pharmacological properties.
  • Chlorinated Compounds: The inclusion of chlorinated components, such as the 4-chlorophenyl and 2,2-dichloroacetyl groups, can enhance the compound's reactivity and interaction with biological systems, making it a point of interest in drug development.
  • Structure-Activity Relationship (SAR): Understanding the relationship between the compound’s structure and its biological activity is crucial. Researchers often study how modifying certain groups can impact efficacy and toxicity.
  • Industrial Significance: Beyond its potential applications in medicine, this compound could also have applications in materials science or agrochemicals, thanks to its structural reactivity.

Due to its intricate design, 1-(4-chlorophenyl)-2-[4-(2,2-dichloroacetyl)anilino]-2-hydroxy-ethanone serves as a perfect example of how synthetic chemistry can lead to the development of molecules with diverse applications. The exploration of such compounds not only broadens our understanding of chemical interactions but also drives innovation in various scientific fields.

Synonyms
1-(4-Chlorophenyl)-2-((4-(dichloroacetyl)phenyl)amino)-2-hydroxyethanone
Ketone, 1-(4-chlorophenyl)-2-((4-(dichloroacetyl)phenyl)amino)-2-hydroxy-
27700-41-0
ETHANONE, 1-(4-CHLOROPHENYL)-2-((4-(DICHLOROACETYL)PHENYL)AMINO)-2-HYDROXY-
RefChem:341216
DTXSID60950375
1-(4-Chlorophenyl)-2-[4-(dichloroacetyl)anilino]-2-hydroxyethan-1-one