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Clotiamidine

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Identification
Molecular formula
C13H13ClN4
CAS number
104206-82-8
IUPAC name
1-(4-chlorophenyl)-2-(4,6-dimethylpyrimidin-2-yl)guanidine
State
State

At room temperature, clotiamidine is typically found in a solid state. The compound is often found in its crystalline form under ambient conditions.

Melting point (Celsius)
171.00
Melting point (Kelvin)
444.15
Boiling point (Celsius)
469.50
Boiling point (Kelvin)
742.65
General information
Molecular weight
261.72g/mol
Molar mass
261.7160g/mol
Density
1.3400g/cm3
Appearence

Clotiamidine is a crystalline solid that can appear as white to pale yellow in color. Its structure consists of aromatic rings that may impart a faint color depending on the level of purity and the specific physical form of the sample.

Comment on solubility

Solubility of 1-(4-chlorophenyl)-2-(4,6-dimethylpyrimidin-2-yl)guanidine

The solubility of the compound 1-(4-chlorophenyl)-2-(4,6-dimethylpyrimidin-2-yl)guanidine can be influenced by its molecular structure and interactions with solvents. Here are some essential insights into its solubility characteristics:

  • Polarity: This compound features both polar and non-polar regions, which can affect how it dissolves in different solvents.
  • Solvent Type: It is likely to demonstrate varying solubility in:
    • Water: Potentially low solubility due to hydrophobic aromatic portions.
    • Organic solvents: Likely to be more soluble in solvents like ethanol or dimethyl sulfoxide (DMSO) due to better interaction between their molecular structures.
  • Temperature Influence: Increased temperature may promote solubility, allowing greater interaction between the solute and solvent molecules.

Understanding the solubility behavior of 1-(4-chlorophenyl)-2-(4,6-dimethylpyrimidin-2-yl)guanidine is crucial for its application in chemical synthesis and pharmaceuticals. As with many compounds, a comprehensive solubility profile can be essential for predicting its behavior in various environments.

Interesting facts

1-(4-Chlorophenyl)-2-(4,6-dimethylpyrimidin-2-yl)guanidine: An Interesting Compound

This compound is an intriguing member of the guanidine family, known for its diverse applications in medicinal chemistry and organic synthesis. Here are some interesting facts about this unique compound:

  • Pharmacological Potential: Compounds containing guanidine structures are often investigated for their pharmacological properties. The presence of a chlorophenyl group can enhance the bioactivity of the molecule, potentially impacting its therapeutic effects.
  • Structure and Function: The dual role of the 4,6-dimethylpyrimidine group suggests that this compound might interact with biological targets through specific mechanisms, such as enzyme inhibition or receptor binding. This could provide insight into its effects on biological systems.
  • Synthetic Versatility: The guanidine framework is recognized for its ability to be modified easily, making it a useful intermediate in the synthesis of more complex compounds. This versatility can pave the way for the development of new drugs.
  • Cognitive Enhancement: Some studies suggest that guanidine derivatives may exhibit cognitive-enhancing effects, which can make them candidates for treating neurological disorders. The unique pyrimidine moiety may contribute to this property.
  • Research Applications: This compound can serve as a valuable tool in chemical research, providing insights into structure-activity relationships and helping researchers design new pharmaceuticals tailored for specific therapeutic needs.

Overall, 1-(4-chlorophenyl)-2-(4,6-dimethylpyrimidin-2-yl)guanidine represents an exciting avenue for exploration in both chemical and biological fields. Its unique structure and potential applications underscore the importance of continued research in understanding its properties and uses.

Synonyms
DTXSID00166817
BRN 0258353
16018-51-2
1-(p-Chlorophenyl)-3-(4,6-dimethyl-2-pyrimidinyl)guanidine
N-(4-Chlorophenyl)-N'-(4,6-dimethyl-2-pyrimidinyl)guanidine
DTXCID5089308
5-25-10-00231 (Beilstein Handbook Reference)
Guanidine, 1-(p-chlorophenyl)-3-(4,6-dimethyl-2-pyrimidinyl)-
SCHEMBL4099597
SCHEMBL4099599
SCHEMBL10501444
SCHEMBL10501448