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Linagliptin

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Identification
Molecular formula
C25H28ClN5O
CAS number
668270-12-0
IUPAC name
1-(4-chlorophenyl)-2-(6-methyl-4-oxo-1H-pyrimidin-2-yl)guanidine
State
State

Linagliptin is a solid under standard conditions and is typically encountered in its pure form as a crystalline powder.

Melting point (Celsius)
202.00
Melting point (Kelvin)
475.15
Boiling point (Celsius)
542.20
Boiling point (Kelvin)
815.35
General information
Molecular weight
472.98g/mol
Molar mass
472.9390g/mol
Density
1.3700g/cm3
Appearence

Linagliptin is a white to yellowish solid. It typically appears as a crystalline powder and may vary slightly in color depending on purity and conditions.

Comment on solubility

Solubility of 1-(4-chlorophenyl)-2-(6-methyl-4-oxo-1H-pyrimidin-2-yl)guanidine

The solubility of the compound 1-(4-chlorophenyl)-2-(6-methyl-4-oxo-1H-pyrimidin-2-yl)guanidine can be influenced by its complex molecular structure. Understanding the factors that affect its solubility is essential for applications in pharmaceuticals and other fields. Here are some key considerations:

  • Molecular Polarities: The presence of various functional groups contributes to a balance between polar and non-polar characteristics.
  • Hydrogen Bonding: The guanidine moiety can engage in hydrogen bonding, which enhances solubility in polar solvents.
  • Solvent Properties: This compound is likely more soluble in polar solvents such as water or alcohols, while showing limited solubility in non-polar solvents.
  • Temperature Effects: Higher temperatures may increase solubility, allowing for greater interaction with solvent molecules.
  • pH Sensitivity: Solubility can also be pH-dependent, particularly due to the ionizable groups present in the structure.

In conclusion, the solubility of 1-(4-chlorophenyl)-2-(6-methyl-4-oxo-1H-pyrimidin-2-yl)guanidine is determined by its molecular interactions and environmental conditions. This understanding is pivotal for tailoring formulations and optimizing its use in various applications.

Interesting facts

Interesting Facts about 1-(4-chlorophenyl)-2-(6-methyl-4-oxo-1H-pyrimidin-2-yl)guanidine

This compound, known for its unique structure and properties, belongs to a class of molecules that are often explored in medicinal chemistry. It exhibits potential as a pharmaceutical agent and has garnered attention for its biological activity.

Key Features:

  • Pharmacological Interest: This compound is investigated for its role in therapeutic applications, particularly in the fields of antimicrobial and anti-inflammatory research.
  • Structural Diversity: The combination of a chlorophenyl group and a pyrimidinyl moiety provides a rich platform for modifications, making it a versatile scaffold for drug development.
  • Active Research Area: Researchers are continuously exploring its behavior in biological systems, including its mechanism of action, efficacy, and safety profiles.

Furthermore, the guanidine functional group is significant in organic and medicinal chemistry due to its basicity and ability to participate in hydrogen bonding. As noted by chemists, “The synthesis of compounds with guanidine functionality often leads to novel biological activities.”
This opens up potential pathways for creating new drugs that might offer enhanced therapeutic benefits.

Potential Applications:

  • Antimicrobial agents: Holds promise in combating infectious diseases.
  • Anti-inflammatory drugs: Could be useful in treating conditions characterized by inflammation.
  • Cancer therapy: May be explored for its potential effects in cancer treatment protocols.

In conclusion, 1-(4-chlorophenyl)-2-(6-methyl-4-oxo-1H-pyrimidin-2-yl)guanidine represents a fascinating area of study in chemical science. Its structural intricacies and potential biological implications make it a compound of significant interest for future research.