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Clotrimazole

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Identification
Molecular formula
C22H17ClN2O
CAS number
23593-75-1
IUPAC name
1-(4-chlorophenyl)-2-imidazol-1-yl-ethanone
State
State

At room temperature, Clotrimazole is solid. It is generally available in a powder form and is used in pharmaceutical preparations.

Melting point (Celsius)
147.50
Melting point (Kelvin)
420.70
Boiling point (Celsius)
419.19
Boiling point (Kelvin)
692.34
General information
Molecular weight
344.85g/mol
Molar mass
344.8450g/mol
Density
1.2489g/cm3
Appearence

Clotrimazole typically appears as a white or pale yellow crystalline powder. It is odorless and has a slightly bitter taste. The compound is stable under normal temperatures and pressures.

Comment on solubility

Solubility of 1-(4-chlorophenyl)-2-imidazol-1-yl-ethanone

The solubility of 1-(4-chlorophenyl)-2-imidazol-1-yl-ethanone exhibits some interesting characteristics that are important to consider:

  • Polarity: The presence of the imidazole ring potentially increases the polarity of the compound, which can enhance its solubility in polar solvents.
  • Solvent Interaction: It is expected to be more soluble in polar protic solvents such as water and alcohols due to hydrogen bonding capabilities.
  • Hydrophobic Effects: However, its aromatic chlorophenyl group introduces a degree of hydrophobicity that may limit its solubility in highly polar solvents.
  • Considerations: Factors such as temperature and pH can also influence solubility; as temperature increases, solubility in many organic compounds generally increases.

In summary, while 1-(4-chlorophenyl)-2-imidazol-1-yl-ethanone may exhibit reasonable solubility in polar solvents, its unique structural characteristics mean that experimental determination of solubility is crucial for practical applications. It’s essential to test solubility under various conditions to fully understand its behavior.

Interesting facts

Interesting Facts About 1-(4-chlorophenyl)-2-imidazol-1-yl-ethanone

1-(4-chlorophenyl)-2-imidazol-1-yl-ethanone is a fascinating compound that belongs to the class of imidazole derivatives. This molecule has garnered significant interest in the field of medicinal chemistry due to its potential biological activities and applications.

Key Features and Potential Applications

  • Biological Activity: Research indicates that imidazole derivatives may exhibit a range of pharmacological effects, making them valuable in drug design. The presence of the 4-chlorophenyl group enhances its interactions with biological targets.
  • Antimicrobial Properties: Some studies suggest that compounds with imidazole rings are effective against various microorganisms, making them relevant in the development of new antimicrobial agents.
  • Role in Coordination Chemistry: Imidazole is often a ligand in coordination complexes, potentially influencing catalytic and electronic properties in advanced materials.

Furthermore, the versatility of the imidazole ring allows for modifications that can tailor the compound for specific applications, such as:

  1. Agricultural Chemistry: Potential use as a pesticide due to its biological activity.
  2. Pharmaceutical Research: Continued exploration of its derivatives might lead to novel therapeutics.
  3. Bioorganic Studies: Understanding its mechanism of action can provide insights into how compounds interact with biological systems.

As we delve deeper into the properties of this compound, it is essential to appreciate its structure and functionality. The *imidazole* moiety contributes not only to its chemical behavior but also to its engagement in a variety of biochemical pathways. The exploration of 1-(4-chlorophenyl)-2-imidazol-1-yl-ethanone embodies the excitement of modern chemistry, where each compound represents a potential key to scientific advancement.

Synonyms
24155-32-6
1-(4-Chlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-one
1-(4-chlorophenyl)-2-(1h-imidazol-1-yl)ethanone
DTXSID60178855
RefChem:1054325
DTXCID20101346
246-040-4
1-(4-chlorophenyl)-2-(1H-imidazol-1-yl)-1-ethanone
1-(4-chlorophenyl)-2-imidazol-1-ylethanone
MFCD00215352
EINECS 246-040-4
MLS001165449
CHEMBL162057
SCHEMBL10247505
PWFVNVYRKXDPGV-UHFFFAOYSA-N
HMS2867C04
AKOS009984491
NCGC00246522-01
AC-16383
SMR000549592
CS-0328251
NS00027568
1-(4-chlorophenyl)-2-imidazol-1-yl-ethanone
1E-184