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Chalcone derivative

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Identification
Molecular formula
C27H26ClNO2
CAS number
NA
IUPAC name
1-(4-chlorophenyl)-2-phenyl-3-[4-(2-pyrrolidin-1-ylethoxy)phenyl]prop-2-en-1-one
State
State

This compound is typically a solid at room temperature. Its crystalline form gives it a rigid structure, and it may appear powdery or granular depending upon specific conditions of synthesis and storage.

Melting point (Celsius)
128.00
Melting point (Kelvin)
401.15
Boiling point (Celsius)
457.00
Boiling point (Kelvin)
730.15
General information
Molecular weight
399.91g/mol
Molar mass
399.9110g/mol
Density
1.2251g/cm3
Appearence

This compound typically appears as a pale yellow to yellow crystalline solid. The intensity of the yellow can depend on the exact chemical environment or the presence of impurities. It might also appear as a powder.

Comment on solubility

Solubility Insights

The compound 1-(4-chlorophenyl)-2-phenyl-3-[4-(2-pyrrolidin-1-ylethoxy)phenyl]prop-2-en-1-one exhibits intriguing solubility characteristics that are influenced by its unique structure. Understanding its solubility is critical for its applications in various fields.

Key Factors Influencing Solubility

  • Polarity: The presence of both aromatic and aliphatic groups in the chemical structure affects the polarity of the compound. Generally, nonpolar compounds have lower solubility in polar solvents.
  • Hydrogen Bonding: The functional groups, particularly the ethoxy group, may participate in hydrogen bonding, thereby enhancing solubility in polar solvents such as ethanol or methanol.
  • Temperature Dependency: Like many organic compounds, the solubility may increase with temperature, making it essential to consider the conditions under which the compound is utilized.

In practical terms, researchers often find that:

  • The compound may be more soluble in organic solvents such as dimethyl sulfoxide (DMSO) or acetone.
  • Limited solubility in water due to its large hydrophobic aromatic groups.
  • Solubility testing in various pH levels may reveal changes in its characteristics, particularly if ionizable groups are involved.

Overall, the solubility profile of 1-(4-chlorophenyl)-2-phenyl-3-[4-(2-pyrrolidin-1-ylethoxy)phenyl]prop-2-en-1-one is a dynamic aspect that merits detailed investigation to optimize its use in chemical applications.

Interesting facts

Interesting Facts about 1-(4-chlorophenyl)-2-phenyl-3-[4-(2-pyrrolidin-1-ylethoxy)phenyl]prop-2-en-1-one

This compound belongs to a fascinating class of compounds known as chalcones, which are characterized by their unique structure comprising of two aromatic rings joined by an enone unit. Chalcones have garnered significant interest in the field of medicinal chemistry due to their diverse biological activities.

Key Attributes of Chalcones:

  • Bioactivity: Research indicates that chalcones exhibit a variety of pharmacological effects, including anti-inflammatory, antimicrobial, and anticancer properties.
  • Natural Sources: Several naturally occurring chalcones have been isolated from plants, leading to investigations into their potential health benefits.
  • Synthetic Versatility: The structural versatility of chalcones allows chemists to modify their components, which can increase their efficacy as drug candidates.

For instance, this specific compound, with its intricate combination of chlorophenyl and pyrrolidine moieties, suggests the potential for enhanced biological activity and selectivity in pharmacological applications. The pyrrolidine moiety may contribute to unique interactions within biological systems, making it a valuable subject of study.

Exciting Research Directions:

  • Drug Development: Ongoing research aims to explore the use of chalcones in drug formulation and therapy for various diseases, including cancer.
  • Structure-Activity Relationship (SAR): Investigations into how structural modifications influence biological activity can pave the way for designing more effective therapeutic agents.
  • Mechanistic Studies: Understanding the mechanisms of action of chalcones can lead to the identification of new drug targets and pathways in disease treatment.

In summary, the compound 1-(4-chlorophenyl)-2-phenyl-3-[4-(2-pyrrolidin-1-ylethoxy)phenyl]prop-2-en-1-one exemplifies the rich potential of chalcones in pharmaceutical research. The exploration of its chemical properties and biological implications continues to inspire scientists and contribute to advancements in medicinal chemistry.