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Pipamperone

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Identification
Molecular formula
C26H30ClN3O2
CAS number
1893-33-0
IUPAC name
1-[(4-chlorophenyl)-phenyl-methyl]-4-(m-tolylmethyl)piperazine
State
State

At room temperature, Pipamperone is typically found in a solid state.

Melting point (Celsius)
98.00
Melting point (Kelvin)
371.15
Boiling point (Celsius)
659.10
Boiling point (Kelvin)
932.25
General information
Molecular weight
416.00g/mol
Molar mass
416.0040g/mol
Density
1.1740g/cm3
Appearence

Pipamperone is a white solid substance. It may appear as a powder or crystalline form.

Comment on solubility

Solubility of 1-[(4-chlorophenyl)-phenyl-methyl]-4-(m-tolylmethyl)piperazine

The solubility of 1-[(4-chlorophenyl)-phenyl-methyl]-4-(m-tolylmethyl)piperazine (C26H30ClN3O2) can be intriguing to explore due to its complex structure. This compound exhibits *limited solubility* in water but may be more soluble in organic solvents. Here are some noteworthy points regarding its solubility:

  • Polar vs. Nonpolar Solvents: The presence of the chlorophenyl and tolumbres groups indicates a tendency toward greater solubility in nonpolar organic solvents such as ether or benzene.
  • Effects of Temperature: Increasing temperature often enhances solubility, particularly in nonpolar media.
  • pH Dependency: The solubility may vary with pH, as functional groups may ionize under different pH levels, affecting solvation.
  • Hydrophobic Interactions: The bulky aromatic groups in the structure could lead to strong hydrophobic interactions, thus limiting solubility in aqueous environments.

In summary, while 1-[(4-chlorophenyl)-phenyl-methyl]-4-(m-tolylmethyl)piperazine may not dissolve well in water, its solubility in organic solvents and the influence of temperature and pH make it a compound of significant interest in the field of pharmacology and organic chemistry.

Interesting facts

Interesting Facts about 1-[(4-chlorophenyl)-phenyl-methyl]-4-(m-tolylmethyl)piperazine

This compound, commonly known in the field of medicinal chemistry, exhibits fascinating properties that can have significant implications in pharmacology. Here are some noteworthy points to consider:

  • Pharmaceutical Relevance: This compound is structurally related to piperazine derivatives, which are widely used in the development of drugs, particularly in the treatment of various neurological disorders.
  • Structural Diversity: The presence of a chlorophenyl and a tolylmethyl group in its structure adds to its versatility, potentially affecting its binding affinity and selectivity towards different receptors.
  • Mechanism of Action: Compounds like this often function by modulating neurotransmitter systems in the brain, which makes them crucial candidates for research into new therapeutic agents for conditions such as anxiety and depression.
  • Chiral Centers: The piperazine moiety introduces chirality, which means that the compound may exist in different stereoisomeric forms, each possibly exhibiting unique biological activity.
  • Research Potential: Chemists are continually exploring modifications to similar compounds to improve their efficacy and reduce side effects, making this compound a valuable subject for future studies.

As the famous chemist "All our knowledge begins with the senses, proceeds then to the understanding, and ends with reason." - The development of compounds like 1-[(4-chlorophenyl)-phenyl-methyl]-4-(m-tolylmethyl)piperazine embodies this journey of scientific discovery, where sensory observations and reasoned modifications pave the way for innovative therapies.

In summary, the implications of this compound stretch far beyond its molecular structure, promising advancements in medicine through ongoing research in its applications and effects.

Synonyms
meclizine
Meclozine
569-65-3
Parachloramine
Bonadettes
Histamethine
Histamethizine
Histametizine
Histametizyne
Peremesin
Postafene
Sea-Legs
Vomisseis
Calmonal
Chiclida
Itinerol
Monamine
Navicalm
Ravelon
Siguran
Suprimal
Travelon
Bonine
Sabari
Neo-istafene
Neo-suprimal
Neo-suprimel
Ancolan
Antivert
1-((4-Chlorophenyl)(phenyl)methyl)-4-(3-methylbenzyl)piperazine
Meclozina
Vomissels
(+-)-Meclizine
Dramamine II
Meclozinum
Ancolon
Meclizine hydrochloride
UCB 5062
UCB 170
Meclozinum [INN-Latin]
Meclozina [INN-Spanish]
Meclozine [INN]
Bonamine
Diadril
U.C.B. 5062
NSC 169189
HSDB 3113
1-[(4-chlorophenyl)(phenyl)methyl]-4-[(3-methylphenyl)methyl]piperazine
1-[(4-chlorophenyl)-phenylmethyl]-4-[(3-methylphenyl)methyl]piperazine
1-(p-Chlorobenzhydryl)-4-(m-methylbenzyl)diethylenediamine
UCB 5052
EINECS 209-323-3
1-p-Chlorobenzhydryl-4-m-methylbenzylpiperazine
NSC-169189
BRN 0332002
UNII-3L5TQ84570
1-(p-Chloro-alpha-phenylbenzyl)-4-(m-methylbenzyl)piperazine
3L5TQ84570
Piperazine, 1-(p-chloro-alpha-phenylbenzyl)-4-(m-methylbenzyl)-
1-((4-Chlorophenyl)phenylmethyl)-4-((3-methylphenyl)methyl)piperazine
1-(p-Chlorobenzhydryl)-4-(m-methylbenzyl)piperazine
Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]-
Piperazine,1-[(4-chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]-
U. C. B. 5062
CHEBI:6709
DTXSID0023242
1-(p-Chloro-.alpha.-phenylbenzyl)-4-(m-methylbenzyl)piperazine
Piperazine, 1-((4-chlorophenyl)phenylmethyl)-4-((3-methylphenyl)methyl)-
Subari
Meclozinum (INN-Latin)
Meclozina (INN-Spanish)
Meclizine [INN:BAN]
Nevidoxine
Piperazine, 1-(p-chloro-.alpha.-phenylbenzyl)-4-(m-methylbenzyl)-
Nevidoxine (TN)
Meclozine (BAN)
NSC169189
Meclozin
1-[(4-Chlorophenyl)(phenyl)methyl]-4-(3-methylbenzyl)piperazine
Meclozine?
Diadril (Salt/Mix)
Bonamine (Salt/Mix)
Bonadoxin (Salt/Mix)
Vertizine (Salt/Mix)
Spectrum_000891
MECLIZINE [MI]
MECLIZINE [HSDB]
(.+/-.)-Meclizine
Prestwick0_000457
Prestwick1_000457
Prestwick2_000457
Prestwick3_000457
Spectrum2_000110
Spectrum3_000485
Spectrum4_000037
Spectrum5_000919
MECLIZINE [VANDF]
MECLOZINE [WHO-DD]
SCHEMBL4649
CHEMBL1623
BSPBio_000534
BSPBio_001949
KBioGR_000473
KBioSS_001371
DivK1c_000407
SPBio_000100
SPBio_002473
BPBio1_000588
DTXCID703242
GTPL2757
BDBM81467
KBio1_000407
KBio2_001371
KBio2_003939
KBio2_006507
KBio3_001449
NINDS_000407
Meclizine;Meclozine; Parachloramine
BCP28339
NSC_4034
MFCD00242697
AKOS015951354
DB00737
IDI1_000407
NCGC00018296-02
NCGC00018296-04
NCGC00018296-08
BS-17628
CAS_569-65-3
SBI-0051433.P003
WLN: T6N DNTJ AYR&R DG& D1R C1
AB00053493
NS00000507
EN300-58334
C07116
D08163
D81963
AB00053493_14
AB00053493_15
L001136
Q386441
BRD-A50311610-300-05-4
BRD-A50311610-300-06-2
BRD-A50311610-300-09-6
BRD-A50311610-300-10-4
Z53003552
1-[(4-Chlorophenyl)(phenyl)methyl]-4-(3-methylbenzyl)piperazine #
PIPERAZINE, 1-((4-CHLOROPHENYL)PHENYLMETHYL)-4-((3-METHYPHENYL)METHYL)-
209-323-3