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Cloperastine hydrochloride

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Identification
Molecular formula
C21H26ClN3 · HCl
CAS number
3703-76-2
IUPAC name
1-[(4-chlorophenyl)methyl]-2-(pyrrolidin-1-ium-1-ylmethyl)benzimidazole;chloride
State
State

Cloperastine hydrochloride is typically found as a solid at room temperature. It is used in pharmaceutical applications, particularly in the formulation of cough suppressants.

Melting point (Celsius)
157.00
Melting point (Kelvin)
430.15
Boiling point (Celsius)
281.00
Boiling point (Kelvin)
554.15
General information
Molecular weight
485.39g/mol
Molar mass
485.3870g/mol
Density
1.2000g/cm3
Appearence

Cloperastine hydrochloride appears as a white or off-white crystalline powder. It is typically odorless or has a faint characteristic odor. The compound is usually supplied in a powdered form, which facilitates its use in pharmaceutical formulations.

Comment on solubility

Solubility of 1-[(4-chlorophenyl)methyl]-2-(pyrrolidin-1-ium-1-ylmethyl)benzimidazole;chloride

The solubility of the compound 1-[(4-chlorophenyl)methyl]-2-(pyrrolidin-1-ium-1-ylmethyl)benzimidazole;chloride can be characterized by several key factors:

  • Polarity: As a quaternary ammonium compound, the presence of the pyrrolidinium moiety enhances its solubility in polar solvents, especially in water.
  • Chloride Ion: The inclusion of the chloride ion not only contributes to ionic interactions but also aids in solvation in aqueous environments.
  • Hydrophobic Regions: The 4-chlorophenyl group introduces a degree of hydrophobic character, which can affect solubility in less polar solvents.

Consequently, this compound is expected to be:

  • Highly soluble in polar solvents, particularly in water due to ionic nature and the ability to form hydrogen bonds.
  • Less soluble in non-polar solvents, where the hydrophobic characteristics may lead to reduced interaction and solvation.

As such, understanding the solubility profile of this compound is crucial for its application in various chemical and pharmaceutical settings. The unique balance of hydrophilic and hydrophobic properties provides a fascinating insight into its behavior in different solvent systems.

Interesting facts

Interesting Facts about 1-[(4-chlorophenyl)methyl]-2-(pyrrolidin-1-ium-1-ylmethyl)benzimidazole;chloride

This compound, a member of the class of benzimidazole derivatives, showcases the fascinating interplay of organic chemistry and medicinal applications. With its unique molecular structure, it holds potential therapeutic benefits that make it a notable subject of study.

Key Features

  • Dual Functionalization: The presence of a pyrrolidine moiety combined with a chlorophenyl group gives this compound both lipophilicity and the ability to interact with biological targets.
  • Pharmacological Implications: Compounds like this one are often investigated for their activity against various diseases, including cancer, due to their capability to modify biological pathways.
  • Structural Versatility: The benzimidazole framework is known for its versatility, serving as a core for various active pharmaceuticals.
  • Chlorine Atom Influence: The 4-chlorophenyl group can enhance the compound's potency and bioavailability by affecting how it interacts with enzymes and receptors in the body.

Research and Development

Ongoing research into this compound may unveil additional properties, such as:

  • Antimicrobial Activity: It may possess properties effective against certain bacteria and fungi.
  • Cognitive Effects: Given its structure, studies could explore its potential as a neuroprotective agent or its impact on brain activity.
  • Novel Derivatives: By modifying the existing structure, chemists hope to improve efficacy and reduce toxicity in clinical settings.

In summary, 1-[(4-chlorophenyl)methyl]-2-(pyrrolidin-1-ium-1-ylmethyl)benzimidazole;chloride exemplifies the intrigue of chemical compounds that lie at the intersection of structure and function. As research progresses, this compound could lead to valuable advancements in medicinal chemistry and therapeutic development.