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Berberine chloride

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Identification
Molecular formula
C20H18NO4Cl
CAS number
141433-60-5
IUPAC name
1-[(4-ethoxy-3-methoxy-phenyl)methyl]-6,7-dimethoxy-3-methyl-isoquinolin-2-ium;chloride
State
State

Berberine chloride is typically in a solid state at room temperature. It usually comes in the form of a crystalline powder and is stable in dry air.

Melting point (Celsius)
203.00
Melting point (Kelvin)
476.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
372.83g/mol
Molar mass
372.8300g/mol
Density
1.3700g/cm3
Appearence

Berberine chloride is typically a yellow crystalline powder. Its color can range from bright yellow to gold. The compound refracts light, making it appear bright under direct light. It is often available in powdered or crystalline form for laboratory use.

Comment on solubility

Solubility Insights for 1-[(4-ethoxy-3-methoxy-phenyl)methyl]-6,7-dimethoxy-3-methyl-isoquinolin-2-ium;chloride

The solubility of this compound exhibits some distinct characteristics influenced by its complex structure. Understanding its solubility is critical, especially in various solvents. Here are some key points to consider:

  • Solvent Compatibility: This compound is likely to be soluble in polar organic solvents such as methanol and dimethyl sulfoxide (DMSO). Its ethoxy and methoxy groups can enhance interactions with such solvents.
  • Water Solubility: Given its ionic nature (as indicated by the presence of the chloride ion), it may exhibit some level of solubility in water, though it is expected to be limited due to the bulky isoquinoline structure.
  • Temperature Dependence: As with many organic compounds, solubility may increase with temperature. Therefore, dissolving it in warmer solvents could be more effective.
  • pH Influence: The solubility may also be affected by the pH of the solution, especially if the compound can exist in different ionic forms depending on protonation.

In summary, the solubility of 1-[(4-ethoxy-3-methoxy-phenyl)methyl]-6,7-dimethoxy-3-methyl-isoquinolin-2-ium;chloride is multifaceted and can depend on several factors such as solution pH, temperature, and solvent choice. Understanding these elements is crucial for effective usage and formulation in various applications.

Interesting facts

Interesting Facts about 1-[(4-ethoxy-3-methoxy-phenyl)methyl]-6,7-dimethoxy-3-methyl-isoquinolin-2-ium;chloride

This compound, a member of the isoquinoline family, showcases a fascinating structure that captivates both pharmaceutical chemists and researchers interested in organic synthesis. Here are some noteworthy aspects:

  • Biological Relevance: Compounds like this one are often studied for their potential biological activities. Isoquinolines have been linked to various pharmacological effects, which makes them vital in drug discovery efforts.
  • Complex Structure: The intricate arrangement of methoxy and ethoxy groups on the phenyl ring contributes to the compound's unique reactivity and properties. The positioning of these substituents is key in dictating how the compound interacts with biological targets.
  • Characterization Techniques: Understanding compounds like this often relies on advanced characterization techniques such as NMR (Nuclear Magnetic Resonance) and MS (Mass Spectrometry), allowing scientists to unravel their complex molecular structures.
  • Synthetic Challenges: The synthesis of isoquinoline derivatives can present significant challenges. Researchers often develop novel synthetic pathways to yield these compounds efficiently while minimizing by-products.
  • Potential Applications: Beyond their role as precursors in pharmaceuticals, isoquinoline derivatives are explored for applications in materials science and as ligands in coordination chemistry.
  • Future Directions: Ongoing research is focused on optimizing the pharmacological profiles of compounds within this class, aiming to enhance their effectiveness and reduce side effects for therapeutic use.

In summary, 1-[(4-ethoxy-3-methoxy-phenyl)methyl]-6,7-dimethoxy-3-methyl-isoquinolin-2-ium;chloride represents a promising area of study within medicinal chemistry. Its unique structure and biological potential set the stage for exciting scientific discoveries ahead.

Synonyms
Dioxyline hydrochloride
UNII-OU67TQZ8RC
Dimoxyline hydrochloride
OU67TQZ8RC
6,7-Dimethoxy-1-(4'-ethoxy-3'-methoxybenzyl)-3-methyl-isoquinoline, hydrochloride
Isoquinoline, 1-(4-ethoxy-3-methoxybenzyl)-6,7-dimethoxy-3-methyl-, hydrochloride
Isoquinoline, 6,7-dimethoxy-1-(4'-ethoxy-3'-methoxybenzyl)-3-methyl-, hydrochloride
5807-56-7
DIMOXYLINE HYDROCHLORIDE [MI]
ISOQUINOLINE, 1-((4-ETHOXY-3-METHOXYPHENYL)METHYL)-6,7-DIMETHOXY-3-METHYL-, HYDROCHLORIDE (1:1)