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Noscapine phosphate

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Identification
Molecular formula
C22H23NO7·H3PO4
CAS number
6082-05-5
IUPAC name
1-[(4-ethoxy-3-methoxy-phenyl)methyl]-6,7-dimethoxy-3-methyl-isoquinoline;phosphoric acid
State
State
The compound is typically found as a crystalline solid at room temperature.

This state allows it to be used efficiently in various pharmaceutical formulations.

Melting point (Celsius)
195.00
Melting point (Kelvin)
468.15
Boiling point (Celsius)
428.00
Boiling point (Kelvin)
701.15
General information
Molecular weight
671.63g/mol
Molar mass
671.6310g/mol
Density
1.2160g/cm3
Appearence

The compound appears as a white to slightly yellowish crystalline powder, often hygroscopic, meaning it can absorb moisture from the environment.

Comment on solubility

Solubility of 1-[(4-ethoxy-3-methoxy-phenyl)methyl]-6,7-dimethoxy-3-methyl-isoquinoline;phosphoric acid

The solubility of the compound 1-[(4-ethoxy-3-methoxy-phenyl)methyl]-6,7-dimethoxy-3-methyl-isoquinoline;phosphoric acid can be intricate and is largely influenced by several factors. Here are some key points to consider:

  • Polarity: The presence of phosphoric acid introduces polar functional groups that can enhance solubility in polar solvents.
  • Hydrogen Bonding: The compound has the potential to participate in hydrogen bonding, which can aid in solubility in aqueous environments.
  • Solvent Dependence: Solubility may vary significantly between different solvents, with possible higher solubility in polar solvents such as water or ethanol.
  • Temperature Effects: Like many organic compounds, solubility may increase with temperature, suggesting that heating the solvent could enhance dissolution.

In practice, it is recommended to experiment with various solvents to determine the specific solubility characteristics of this compound in applicable conditions. The unique combination of aromatic and methoxy groups in the structure further influences its overall solubility profile. Thus, while general trends can be observed, detailed solubility studies are essential to ascertain the optimal conditions for use.

Interesting facts

Interesting Facts about 1-[(4-Ethoxy-3-methoxy-phenyl)methyl]-6,7-dimethoxy-3-methyl-isoquinoline; Phosphoric Acid

The compound 1-[(4-ethoxy-3-methoxy-phenyl)methyl]-6,7-dimethoxy-3-methyl-isoquinoline, complex as it may sound, holds intriguing applications and characteristics that merit attention.

1. Structural Diversity

This compound stands out due to its elaborate structure, featuring a nitrogen-containing isoquinoline core that is modified with various methoxy and ethoxy substituents. Such structural diversity often contributes to unique biological activities, making it a point of interest for medicinal chemistry.

2. Potential Pharmacological Applications

  • Isoquinoline derivatives: Compounds of this class are known for their diverse pharmacological properties, including antimicrobial, anti-inflammatory, and antioxidant activities.
  • Drug Development: Researchers are actively investigating its potential in the development of new therapeutic agents.

3. Phosphoric Acid Complexation

The presence of phosphoric acid in this compound can enhance its solubility and stability, often allowing for improved bioavailability. This interaction can lead to:

  • Increased efficacy: by ensuring that the active component remains in a bioavailable form.
  • Potential targeted delivery: through multiple pathways, possibly improving the selectivity of its biological activities.

4. Research Significance

This compound represents a fascinating area of study within synthetic organic chemistry, with its intricate structure paving the way for:

  • Synthetic challenges: Researchers continuously seek efficient methods to synthesize such complex molecules.
  • Interdisciplinary collaboration: The study of such compounds often necessitates cooperation between chemists, biologists, and pharmacologists.

In summary, 1-[(4-ethoxy-3-methoxy-phenyl)methyl]-6,7-dimethoxy-3-methyl-isoquinoline; phosphoric acid not only embodies the complexity of organic chemistry but also holds promise in the realm of drug discovery and development, making it a valuable subject of scientific inquiry.

Synonyms
Dioxyline phosphate
Paveril phosphate
Paverone
Livera
5667-46-9
DIMOXYLINE PHOSPHATE
9M18MC2SIE
1-[(4-ethoxy-3-methoxyphenyl)methyl]-6,7-dimethoxy-3-methylisoquinoline;phosphoric acid
6,7-Dimethoxy-1-(4'-ethoxy-3'-methoxybenzyl)-3-methylisoquinoline phosphate
6670-95-7
Isoquinoline, 1-((4-ethoxy-3-methoxyphenyl)methyl)-6,7-dimethoxy-3-methyl-, phosphate (1:1)
Isoquinoline, 1-(4-ethoxy-3-methoxybenzyl)-6,7-dimethoxy-3-methyl-, phosphate (1:1)
DIOXYLINEPHOSPHATE
UNII-9M18MC2SIE
EINECS 227-126-0
SCHEMBL4315552
DIMOXYLINE PHOSPHATE [MI]
DTXSID40205234
YZKZXTBSUSEYQZ-UHFFFAOYSA-N
DIMOXYLINE PHOSPHATE [WHO-DD]
AKOS040751596
L-08146
Q27272718
1-((4-Ethoxy-3-methoxyphenyl)methyl)-6,7-dimethoxy-3-methylisoquinolinium dihydrogen phosphate