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4'-fluoro-α-(2-methoxyphenyl)piperazine

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Identification
Molecular formula
C19H21FN2O2
CAS number
95783-69-0
IUPAC name
1-(4-fluorophenyl)-2-[4-(2-methoxyphenyl)piperazin-1-yl]ethanone
State
State

Under standard conditions, this compound exists as a solid.

Melting point (Celsius)
114.50
Melting point (Kelvin)
387.70
Boiling point (Celsius)
576.40
Boiling point (Kelvin)
849.60
General information
Molecular weight
331.39g/mol
Molar mass
331.3750g/mol
Density
1.2350g/cm3
Appearence

This compound typically appears as a solid at room temperature. Its precise appearance can vary based on purity and specific formulation, but it often appears as a white to off-white crystalline powder.

Comment on solubility

Solubility of 1-(4-fluorophenyl)-2-[4-(2-methoxyphenyl)piperazin-1-yl]ethanone

The solubility of 1-(4-fluorophenyl)-2-[4-(2-methoxyphenyl)piperazin-1-yl]ethanone is a pivotal aspect to consider in pharmacological and chemical applications. Understanding its solubility characteristics can significantly influence its behavior in biological systems and its overall effectiveness as a compound.

Some key points to note regarding the solubility of this compound include:

  • Polarity: The presence of a piperazine ring and methoxy group contributes to the overall polarity of the molecule, likely enhancing its solubility in polar solvents.
  • Solvent Compatibility: It is expected to exhibit reasonable solubility in organic solvents like ethanol and dichloromethane, due to its organic nature and the presence of aromatic systems.
  • pH Dependence: The ionization state of the piperazine ring may influence solubility at different pH levels, suggesting that testing in various pH conditions is important.
  • Crystal Form: The solid-state form could also affect solubility; it's worth investigating whether it exists in different polymorphs, each possibly having unique solubility properties.

In conclusion, while the solubility profile of 1-(4-fluorophenyl)-2-[4-(2-methoxyphenyl)piperazin-1-yl]ethanone can be anticipated to be favorable in certain organic solvents due to its structural features, experimental solubility tests across various conditions are essential for precise applications and formulations.

Interesting facts

Interesting Facts about 1-(4-fluorophenyl)-2-[4-(2-methoxyphenyl)piperazin-1-yl]ethanone

This fascinating compound is known for its intriguing properties and potential applications. As a researcher, one cannot help but appreciate the complexity and beauty of its structure, especially the unique combination of both a piperazine and a carbonyl group. Here are some compelling points to consider:

  • Pharmacological Significance: The presence of the piperazine moiety is particularly notable, as piperazine derivatives are widely researched for their activity in treating various mental health disorders. This compound may hold potential as a candidate for further pharmacological exploration.
  • Substituent Effects: With a fluorine atom strategically placed on the aromatic ring, this compound exhibits altered electronic properties. The fluorine substituent can enhance metabolic stability, making it an interesting subject for medicinal chemistry.
  • Molecular Interactions: The methoxy group contributes to the compound's lipophilicity, which can affect its interaction with biological membranes, thereby influencing its bioavailability and overall activity.
  • Synthetic Pathways: The synthesis of this compound involves intricate reactions, allowing students to explore various methods of organic synthesis. Understanding these pathways can deepen one's appreciation of the fundamental concepts of chemistry.
  • Research Implications: This compound not only serves as a model for understanding structure-activity relationships in drug design but also motivates ongoing research to discover new therapeutic agents with enhanced efficacy and safety profiles.

In conclusion, the compound 1-(4-fluorophenyl)-2-[4-(2-methoxyphenyl)piperazin-1-yl]ethanone serves as an intriguing example of how the combination of various chemical groups can lead to potential pharmacological advancements. As scientists and students continue to study this compound, they are reminded of the endless possibilities within the realm of chemical research.

Synonyms
ACETOPHENONE, 4'-FLUORO-2-(4-(o-METHOXYPHENYL)-1-PIPERAZINYL)-
17135-52-3
BRN 0700837
4'-Fluoro-2-(4-(o-methoxyphenyl)-1-piperazinyl)acetophenone
5-23-02-00201 (Beilstein Handbook Reference)
CHEMBL1618951
DTXSID20169067
HMS1694K14
AKOS000775897
NCGC00244975-01
VU0451323-1
SR-01000350642
SR-01000350642-1