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4'-Fluoropropiophenone

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Identification
Molecular formula
C13H16FNO
CAS number
19134-50-0
IUPAC name
1-(4-fluorophenyl)-4-(1-piperidyl)butan-1-one
State
State

At room temperature, 4'-Fluoropropiophenone is typically found in a liquid state.

Melting point (Celsius)
14.00
Melting point (Kelvin)
287.15
Boiling point (Celsius)
254.00
Boiling point (Kelvin)
527.15
General information
Molecular weight
205.27g/mol
Molar mass
205.2700g/mol
Density
1.1720g/cm3
Appearence

4'-Fluoropropiophenone appears as a clear, colorless to pale yellow liquid. It is typically free-flowing and has a subtle, characteristic aromatic odor.

Comment on solubility

Solubility of 1-(4-fluorophenyl)-4-(1-piperidyl)butan-1-one

The solubility of 1-(4-fluorophenyl)-4-(1-piperidyl)butan-1-one can be complex due to its unique structure. Here are some key points to consider:

  • Polarity: The compound contains both a fluorophenyl group and a piperidyl group, which can influence its overall polarity. The presence of the electronegative fluorine atom increases the polarity of the aromatic ring, potentially enhancing solubility in polar solvents.
  • Solvent Compatibility: It is likely to be soluble in a range of polar organic solvents such as ethanol and methanol, while possibly having limited solubility in non-polar solvents due to the piperidyl group's saturation.
  • Hydrogen Bonding: The piperidyl nitrogen can participate in hydrogen bonding, which may increase solubility in protic solvents by forming strong interactions with the solvent molecules.
  • Practical Use: Understanding the solubility properties is essential for its applications, particularly in pharmaceutical formulations, where solubility can dictate absorption and bioavailability.

In conclusion, while the exact solubility data for 1-(4-fluorophenyl)-4-(1-piperidyl)butan-1-one may require empirical testing, its structure suggests a potential for good solubility in polar environments but reduced solubility in non-polar solvents.

Interesting facts

Interesting Facts about 1-(4-fluorophenyl)-4-(1-piperidyl)butan-1-one

1-(4-fluorophenyl)-4-(1-piperidyl)butan-1-one, often referred to by its more common name, is a fascinating compound that has garnered attention in various fields, particularly in medicinal chemistry and pharmacology.

Key Characteristics

  • Potential Therapeutic Applications: This compound has been studied for its potential as a therapeutic agent, showing promise in treating conditions like anxiety and depression.
  • Structural Insights: The presence of the 4-fluorophenyl group is significant as fluorine can influence the biological activity and pharmacokinetics of a molecule, often increasing lipophilicity.
  • Piperidine Moiety: The piperidyl group is known for its role in various pharmaceutical compounds, enhancing binding affinities to neurological pathways, which may contribute to the compound’s effects on the central nervous system.
  • Research Implications: Its unique structure makes it a subject of interest in chemical research, leading to numerous studies aimed at optimizing its efficacy or synthesizing related compounds.

Quote from the Field

As one researcher aptly put it, "Understanding the chemical properties of compounds like 1-(4-fluorophenyl)-4-(1-piperidyl)butan-1-one can provide insights into future therapeutic development and safety profiles."

Conclusion

In summary, 1-(4-fluorophenyl)-4-(1-piperidyl)butan-1-one is not just a simple molecule; it represents a bridge between chemical structure and biological application, underscoring the ever-evolving landscape of medicinal chemistry. The combination of its functional groups and structural nuances contributes to its potential, making it a valuable subject of research in drug development.

Synonyms
Primaperone
1219-35-8
Primaperonum
Primaperona
1-(4-fluorophenyl)-4-piperidin-1-ylbutan-1-one
Primaperone [INN:DCF]
CHEMBL82519
BR551134L6
1-(4-fluorophenyl)-4-(piperidin-1-yl)butan-1-one
Primaperonum [INN-Latin]
Primaperona [INN-Spanish]
UNII-BR551134L6
EINECS 214-941-1
PRIMAPERONE [INN]
SCHEMBL310299
DTXSID50153434
4'-Fluoro-4-piperidinobutyrophenone
BDBM50044442
gamma-piperidino-p-fluorobutyrophenone
AKOS009057837
NS00081177
EN300-6545618
1-(4-Fluoro-phenyl)-4-piperidin-1-yl-butan-1-one
Q27274834
Z137503452