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Ziprasidone

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Identification
Molecular formula
C21H21FN4O1
CAS number
146939-27-7
IUPAC name
1-(4-fluorophenyl)-4-(10-methoxy-6-methyl-1,2,4,5-tetrahydroazepino[4,5-b]indol-3-yl)butan-1-one
State
State

At room temperature, Ziprasidone is a solid. It is usually utilized in its hydrochloride salt form for medical usage, which facilitates its dissolution and absorption in the human body.

Melting point (Celsius)
201.50
Melting point (Kelvin)
474.65
Boiling point (Celsius)
85.00
Boiling point (Kelvin)
358.15
General information
Molecular weight
412.94g/mol
Molar mass
412.9430g/mol
Density
1.3000g/cm3
Appearence

Ziprasidone is typically found as a fine, white to slightly pink powder. It is often provided in pharmaceutical preparations where it is encapsulated or tableted for use in medication. The compound may appear different when formulated with excipients for drug delivery.

Comment on solubility

Solubility Overview

The compound 1-(4-fluorophenyl)-4-(10-methoxy-6-methyl-1,2,4,5-tetrahydroazepino[4,5-b]indol-3-yl)butan-1-one presents interesting solubility characteristics that are influenced by its complex molecular structure.

Solubility Characteristics

  • Polarity: The presence of various functional groups, especially the methoxy and the fluorophenyl groups, contributes to the overall polarity of the molecule, which can enhance solubility in polar solvents.
  • Solvent Compatibility: This compound may exhibit good solubility in solvents such as:
    • Dimethyl sulfoxide (DMSO)
    • Methanol
    • Aqueous buffers at appropriate pH levels
  • Hydrophobic Regions: The hydrophobic portions of the molecule can lead to reduced solubility in water, potentially limiting its application in aqueous environments.
  • Temperature Effects: As with many organic compounds, increased temperature may enhance solubility, making it crucial to consider how thermal conditions affect solubility in practical applications.

In summary, while the solubility of 1-(4-fluorophenyl)-4-(10-methoxy-6-methyl-1,2,4,5-tetrahydroazepino[4,5-b]indol-3-yl)butan-1-one can vary significantly with solvent choice, temperature, and the molecular interactions at play, understanding its solubility profile can guide effective utilization in chemical processes and formulations.

Interesting facts

Interesting Facts about 1-(4-fluorophenyl)-4-(10-methoxy-6-methyl-1,2,4,5-tetrahydroazepino[4,5-b]indol-3-yl)butan-1-one

This compound, a member of the indole family, boasts a fascinating structure that combines various functional groups, making it a subject of interest in both medicinal and synthetic chemistry. Here are several key points to highlight:

  • Complex Structure: The compound features both a tetrahydroazepine ring and an indole moiety, which are known for their diverse biological activities and complexities in synthesis.
  • Potential Pharmacological Applications: Given its indole structure, this compound is likely to exhibit interactions with serotonin receptors, potentially marking it as a candidate for antidepressant or anxiolytic properties.
  • Fluorine's Role: The presence of a fluorine atom in the para-position of the phenyl ring enhances the compound’s lipophilicity and metabolic stability, aspects that are advantageous for drug design.
  • Natural Products Inspiration: The design of this molecule may have been inspired by natural compounds that display complex frameworks, highlighting the importance of nature in synthetic chemistry.
  • Research Interest: Scientists are continually investigating compounds with such intricate designs, as they can lead to new insights and breakthroughs in medicinal chemistry.

In the words of a renowned chemist, “The beauty of chemistry lies not only in the simplicity of reactions but in the complexity of the compounds we can create.” This compound is a testament to that beauty, encouraging further exploration and study in the realm of chemical sciences.

Synonyms
BRN 0711853
24441-77-8
Butyrophenone, 4'-fluoro-4-(10-methoxy-6-methyl-1,4,5,6-tetrahydroazepino(4,5-b)indol-3(2H)-yl)-
DTXSID60179201
4'-Fluoro-4-(10-methoxy-6-methyl-1,4,5,6-tetrahydroazepino(4,5-b)indol-3(2H)-yl)butyrophenone
RefChem:331403
DTXCID50101692