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4'-Fluoroketamine hydrochloride

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Identification
Molecular formula
C19H20ClFN2O
CAS number
1119827-47-0
IUPAC name
1-(4-fluorophenyl)-4-(1,2,3,4-tetrahydroisoquinolin-2-ium-2-yl)butan-1-one;chloride
State
State
At room temperature, 4'-fluoroketamine hydrochloride is a solid. It is commonly found in a powdered or crystalline form.
Melting point (Celsius)
178.00
Melting point (Kelvin)
451.00
Boiling point (Celsius)
236.00
Boiling point (Kelvin)
509.00
General information
Molecular weight
294.78g/mol
Molar mass
294.7750g/mol
Density
1.2470g/cm3
Appearence

4'-Fluoroketamine hydrochloride typically appears as a crystalline solid. The transparency can vary from translucent to opaque, and it often has a whitish or colorless appearance.

Comment on solubility

Solubility of 1-(4-fluorophenyl)-4-(1,2,3,4-tetrahydroisoquinolin-2-ium-2-yl)butan-1-one;chloride

The solubility of 1-(4-fluorophenyl)-4-(1,2,3,4-tetrahydroisoquinolin-2-ium-2-yl)butan-1-one;chloride can be quite complex due to its unique molecular structure. Several factors influence its solubility profile:

  • Polarity: The presence of the tetrahydroisoquinoline moiety along with the chloride ion often leads to a polar character, which may enhance solubility in polar solvents.
  • Hydrogen Bonding: The potential for hydrogen bonding interactions between the compound and solvent molecules can significantly affect solubility, especially in a water-based medium.
  • Utilization of Solvents: Experimentation typically shows better solubility in organic solvents such as ethanol or dimethyl sulfoxide (DMSO) as opposed to water.
  • Temperature Effects: Often, increasing the temperature during dissolution can improve the solubility of such compounds.

As a general rule, when considering the solubility of complex organic compounds like this one, it is crucial to analyze both the alkyl chain and the aromatic rings present. This combination can lead to varying solubility results based on the chosen solvent as well as environmental conditions.

In conclusion, while the overall solubility may seem limited in certain environments, understanding the specific interactions at play can lead to effective solubilization techniques.

Interesting facts

Interesting Facts About 1-(4-fluorophenyl)-4-(1,2,3,4-tetrahydroisoquinolin-2-ium-2-yl)butan-1-one;chloride

This complex organic compound, often simplified in discussions, is notable for its applications in medicinal chemistry and drug design. Here are some intriguing points to consider:

  • Pharmaceutical Relevance: The compound's structure suggests potential usefulness in developing treatments for neurological disorders. The presence of the tetrahydroisoquinoline moiety is particularly significant, as this structure is a common component in several bioactive compounds.
  • Mechanism of Action: The unique combination of the 4-fluorophenyl group and the tetrahydroisoquinoline might influence its pharmacological properties. Fluorine atoms can improve metabolic stability and lipophilicity, potentially enhancing the compound's effectiveness in biological systems.
  • Research Insights: Studies have indicated that similar compounds exhibit neurotransmitter modulation, which could pave the way for innovative antidepressants or anxiolytics.
  • Synthetic Pathways: The synthesis of this compound involves relatively sophisticated organic reactions. This provides a fascinating opportunity for chemists to explore various synthetic methodologies and reaction conditions.
  • Exploration in Neuropharmacology: Compounds of this nature are valuable in neuropharmacological research, aiding scientists in understanding the pathways involved in mood regulation and cognitive function.

Overall, the compound's intricate structure and the potential properties derived from its components offer endless avenues for research and application in the field of chemistry and pharmacology. As scientists continue to explore such compounds, we gain deeper insights into the intricate interplay of chemical structures and biological functions.

Synonyms
p-Fluoro-4-(1,2,3,4-tetrahydroisoquinolinyl)butyrophenone hydrochloride
15997-83-8
1-(4-fluorophenyl)-4-(1,2,3,4-tetrahydroisoquinolin-2-ium-2-yl)butan-1-one;chloride
BUTYROPHENONE, 4'-FLUORO-4-(1,2,3,4-TETRAHYDROISOQUINOLIN-2-YL)-, HYDROCHLORIDE