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4'-Fluorocinnamoyl chloride

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Identification
Molecular formula
C10H8ClFO
CAS number
2200-63-3
IUPAC name
1-(4-fluorophenyl)-4-[3-(2-methoxyphenoxy)pyrrolidin-1-yl]butan-1-one;hydrochloride
State
State

At room temperature, the compound is typically found in a solid state.

Melting point (Celsius)
89.00
Melting point (Kelvin)
362.15
Boiling point (Celsius)
311.00
Boiling point (Kelvin)
584.15
General information
Molecular weight
238.65g/mol
Molar mass
238.6530g/mol
Density
1.2103g/cm3
Appearence

The compound appears as a crystalline solid and is typically white to off-white in color.

Comment on solubility

Solubility of 1-(4-fluorophenyl)-4-[3-(2-methoxyphenoxy)pyrrolidin-1-yl]butan-1-one;hydrochloride

The solubility of 1-(4-fluorophenyl)-4-[3-(2-methoxyphenoxy)pyrrolidin-1-yl]butan-1-one;hydrochloride can be an intriguing aspect of its chemical behavior. This compound, being a hydrochloride salt, typically exhibits enhanced solubility in polar solvents compared to its free base form. This is due to the ionization of the hydrochloride group, which allows for stronger interactions with the solvent molecules.

Factors Influencing Solubility:

  • Polarity: The presence of polar functional groups, such as the methoxy and pyrrolidine moieties, increases affinity for polar solvents.
  • Temperature: Generally, as the temperature increases, solubility in most solvents increases due to greater molecular movement.
  • pH Levels: The ionization state of the compound can vary with pH, affecting solubility in certain environments.

Commonly, hydrochlorides are more soluble in water. Therefore, one can expect that this compound may dissolve well in aqueous solutions, useful for applications that rely on bioavailability and efficacy in biological systems. It's essential to note that while the hydrochloride variant may demonstrate these solubility characteristics, the free base form may require different solvents or conditions for optimal dissolution.

In summary, understanding the solubility of 1-(4-fluorophenyl)-4-[3-(2-methoxyphenoxy)pyrrolidin-1-yl]butan-1-one;hydrochloride is crucial for its application in pharmacology and formulations, as solubility plays a significant role in the effectiveness and delivery of pharmaceutical compounds.

Interesting facts

Interesting Facts about 1-(4-fluorophenyl)-4-[3-(2-methoxyphenoxy)pyrrolidin-1-yl]butan-1-one; hydrochloride

This compound, commonly referred to in scientific literature as a complex pharmaceutical agent, exhibits intriguing pharmacological properties. Here are some fascinating aspects of this compound:

  • Pharmacological Potential: The compound is often explored for its capacity to function as a selective serotonin reuptake inhibitor (SSRI), which may contribute to its use in treating various mood disorders.
  • Structural Features: The integration of a 4-fluorophenyl moiety is significant since fluorine substitution can enhance a compound's lipophilicity, potentially improving its bioavailability.
  • Pyrrolidine Ring: The presence of the pyrrolidine ring is noteworthy; these cyclic amines are frequently associated with various biological activities, making this compound of great interest in medicinal chemistry.
  • Versatility in Drug Design: As part of the evolving landscape of drug formulations, this compound exemplifies how structural modifications can lead to novel therapeutic agents targeting specific biochemical pathways.
  • Research Applications: Various studies have investigated the potential neurochemical mechanisms of this compound, aiming to understand how it impacts neurotransmitter dynamics and contributes to mental health treatment.

In essence, 1-(4-fluorophenyl)-4-[3-(2-methoxyphenoxy)pyrrolidin-1-yl]butan-1-one; hydrochloride stands as a compelling example of contemporary approaches in pharmacology. This compound not only enriches the field of medicinal chemistry but also presents immense opportunities for novel therapies targeting mental health conditions. As researchers continue to dissect its mechanisms of action, its full therapeutic potential remains to be fully realized.

Synonyms
21492-45-5
AHR-1900 hydrochloride
KRS9VEH7W5
4'-Fluoro-4-(3-(2-methoxyphenoxy)-1-pyrrolidinyl)butyrophenone hydrochloride
UNII-KRS9VEH7W5
BUTYROPHENONE, 4'-FLUORO-4-(3-(2-METHOXYPHENOXY)-1-PYRROLIDINYL)-, HYDROCHLORIDE
4'-FLUORO-4-(3-(O-METHOXYPHENOXY)-1-PYRROLIDINYL)BUTYROPHENONE HYDROCHLORIDE
1-BUTANONE, 1-(4-FLUOROPHENYL)-4-(3-(2-METHOXYPHENOXY)-1-PYRROLIDINYL)-, HYDROCHLORIDE (1:1)
RefChem:199399
1-(4-fluorophenyl)-4-[3-(2-methoxyphenoxy)pyrrolidin-1-yl]butan-1-one;hydrochloride
orb1698655
DTXSID40944095
AKOS040750221
AHR-1900 hydrochloride, AHR-1900 HCl
1-(4-Fluorophenyl)-4-[3-(2-methoxyphenoxy)pyrrolidin-1-yl]butan-1-one--hydrogen chloride (1/1)