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Paroxetine hydrochloride

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Identification
Molecular formula
C19H21ClFN2O3
CAS number
110429-35-1
IUPAC name
1-(4-fluorophenyl)-4-[4-(2-methoxyphenyl)piperazin-1-ium-1-yl]butan-1-one;chloride
State
State

Paroxetine hydrochloride is typically in a solid state at room temperature. It is stable under normal temperatures and pressures.

Melting point (Celsius)
120.00
Melting point (Kelvin)
393.00
Boiling point (Celsius)
300.00
Boiling point (Kelvin)
573.00
General information
Molecular weight
329.82g/mol
Molar mass
329.8210g/mol
Density
1.3567g/cm3
Appearence

Paroxetine hydrochloride appears as a white to off-white crystalline powder. It is often available in tablet or capsule form when used as a medication.

Comment on solubility

Solubility Insights on 1-(4-fluorophenyl)-4-[4-(2-methoxyphenyl)piperazin-1-ium-1-yl]butan-1-one;chloride

The solubility of the compound 1-(4-fluorophenyl)-4-[4-(2-methoxyphenyl)piperazin-1-ium-1-yl]butan-1-one;chloride can be characterized by several intriguing aspects:

  • Solvent Dependency: This compound exhibits varying solubility in different solvents. It is generally more soluble in polar solvents such as water and methanol due to ion-dipole interactions.
  • Ionic Nature: As a salt (indicated by the chloride anion), it displays high solubility in aqueous solutions which can enhance its bioavailability.
  • Temperature Influence: Increased temperatures often lead to higher solubility rates for many organic compounds, making it a relevant factor for solubility studies.
  • pH Sensitivity: The solubility can also be influenced by the pH of the solution, given the presence of a piperazine moiety that can be protonated, thereby increasing the solubility in acidic conditions.

In summary, when studying the solubility characteristics of this compound, it is essential to consider the solvent type, temperature, and pH to fully understand its behavior in various environments. As stated, "The interactions between solute and solvent define the solubility landscape." Thus, these factors play a crucial role in optimizing the application of this compound in different fields.

Interesting facts

Interesting Facts about 1-(4-fluorophenyl)-4-[4-(2-methoxyphenyl)piperazin-1-ium-1-yl]butan-1-one;chloride

This compound is an intriguing example of a quaternary ammonium compound that showcases the complex interplay between organic chemistry and pharmacology. Here are some captivating insights:

  • Pharmaceutical Relevance: The structure indicates potential pharmaceutical applications, often linked to the behavior of drugs that target neurotransmitter systems. It may influence serotonin and dopamine pathways, making it a candidate for mood-related disorders.
  • Unique Structure: The presence of both a fluorine atom and a methoxy group allows for a unique interaction with biological targets, which can enhance the compound's potency and selectivity.
  • Piperazine Moiety: The piperazine ring is a well-known scaffold in medicinal chemistry, frequently utilized in the development of antipsychotic and antidepressant medications due to its favorable pharmacological properties.
  • Ionization Behavior: This compound exists as a chloride salt, which impacts its solubility and stability in various conditions, making it easier to handle during synthesis and formulation.
  • Research Interest: Scientists are continuously investigating similar compounds for their ability to modulate receptor activity, exploring their structural-activity relationships (SAR) to optimize efficacy and reduce side effects.

The exploration of such compounds emphasizes the significance of molecular design in developing new therapeutic agents that can target specific biological systems. As chemistry continues to advance, compounds like this one will play a crucial role in shaping future medical treatments.

Synonyms
Hypnorm
17160-71-3
Companin
1-(4-fluorophenyl)-4-[4-(2-methoxyphenyl)piperazin-1-ium-1-yl]butan-1-one;chloride
Sedavic
Solusediv
Haloanisone compositum
Fluanisone hydrochloride
BUTYROPHENONE, 4'-FLUORO-4-(4-(o-METHOXYPHENYL)-1-PIPERAZINYL)-, HYDROCHLORIDE