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Fluxoybiprazol

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Identification
Molecular formula
C21H29FN2O2
CAS number
5746-46-7
IUPAC name
1-(4-fluorophenyl)-4-[4-(2-methoxyphenyl)piperazin-1-yl]butan-1-ol
State
State

At room temperature, Fluxoybiprazol is in a solid state. It is commonly handled in its powder form for pharmaceutical and research applications.

Melting point (Celsius)
158.50
Melting point (Kelvin)
431.70
Boiling point (Celsius)
502.15
Boiling point (Kelvin)
775.30
General information
Molecular weight
366.47g/mol
Molar mass
366.4700g/mol
Density
1.2050g/cm3
Appearence

Fluxoybiprazol typically appears as a white crystalline powder. Its appearance may vary depending on the specific formulation and state of purity.

Comment on solubility

Solubility of 1-(4-fluorophenyl)-4-[4-(2-methoxyphenyl)piperazin-1-yl]butan-1-ol

The solubility of 1-(4-fluorophenyl)-4-[4-(2-methoxyphenyl)piperazin-1-yl]butan-1-ol can be influenced by various factors, including its molecular structure, polarity, and intermolecular interactions. This compound, with its complex organic structure, presents some interesting solubility attributes:

  • Polarity: The presence of polar functional groups such as the hydroxyl (-OH) and piperazine moiety suggests that the compound may exhibit reasonable solubility in polar solvents, including water.
  • Hydrophobic Interactions: The aromatic rings and alkyl chain contribute to hydrophobic interactions, which may limit solubility in highly polar solvents but enhance solubility in non-polar organic solvents.
  • Solvent Compatibility: This compound may be more soluble in solvents like ethanol, methanol, and dimethyl sulfoxide (DMSO) compared to traditional hydrocarbon solvents.
  • Temperature Effects: Like many organic compounds, solubility may increase with temperature, suggesting that warm solutions could enhance dissolution rates.
  • pH Sensitivity: The solubility could also be affected by the pH of the solution, particularly through protonation or deprotonation of the piperazine. It is typically expected that solubility will vary in acidic, neutral, and basic conditions.

In conclusion, understanding the solubility behavior of this compound is essential for its potential applications in pharmacology and material science, where the effects of solubility can significantly impact bioavailability and efficacy.

Interesting facts

Exploring 1-(4-Fluorophenyl)-4-[4-(2-methoxyphenyl)piperazin-1-yl]butan-1-ol

This intriguing compound belongs to a class of compounds known as piperazines, which are recognized for their significance in medicinal chemistry. It exhibits many features that make it a subject of interest among scientists and chemists.

Key Features

  • Pharmacological Importance: Compounds containing piperazine structures are often studied for their potential therapeutic effects, particularly in the treatment of various psychiatric disorders.
  • Fluorine Substitution: The presence of a fluorine atom in the phenyl ring enhances the lipophilicity and bioavailability of the compound, allowing for better interaction with biological targets.
  • Functional Groups: The compound showcases various functional groups, including hydroxyl and ether, which can significantly alter its pharmacodynamic properties.
  • Synthetic Pathways: The complexity of its synthesis offers rich grounds for exploration in organic chemistry, as the introduction of both the fluorine atom and methoxy group requires careful consideration of reaction conditions.

Scientific Insights

According to research, compounds with similar structures have been linked to various biological activities, such as:

  • Antidepressant effects
  • Antipsychotic capabilities
  • Potential applications in treating anxiety disorders

"The structure-activity relationship (SAR) of piperazine derivatives reveals the significance of small modifications leading to substantial changes in activity."

Interestingly, the presence of the methoxy group contributes to its ability to cross the blood-brain barrier, which is essential for drug candidates intended for central nervous system targeting. Beyond pharmacology, this compound serves as a fascinating example for students learning about the interplay between structure and function in organic compounds, bridging the gap between theoretical chemistry and practical application.

Synonyms
Anisopirol
Haloisol
857-62-5
Anisopirol [INN]
R 2159
NSC-167758
162A01WTAJ
CHEMBL104515
1-(4-fluorophenyl)-4-[4-(2-methoxyphenyl)piperazin-1-yl]butan-1-ol
1-Piperazinebutanol, alpha-(4-fluorophenyl)-4-(2-methoxyphenyl)-
1-Piperazinebutanol, beta-(p-fluorophenyl)-4-(o-methoxyphenyl)-, (+-)-
dl-1-(4-Fluorophenyl)-4-(1-(4-(2-methoxyphenyl))piperazinyl)butanol
Anisopirolum
Amisopirol
1-Piperazinebutanol, beta-(4-fluorophenyl)-4-(2-methoxyphenyl)-
(+-)-beta-(p-Fluorophenyl)-4-(o-methoxyphenyl)-1-piperazinebutanol
R-2159
13382-33-7
NSC 167758
BRN 0711238
UNII-162A01WTAJ
1-(4-p-Fluorophenyl-4-hydroxybutyl)-4-o-methoxy-phenylpiperazine
alpha-(3-(4-(o-Methoxyphenyl)-1-piperazinyl)propyl)-p-fluorobenzyl alcohol
5-23-02-00063 (Beilstein Handbook Reference)
SCHEMBL2111067
DTXSID20861938
1-Piperazinebutanol, alpha-(p-fluorophenyl)-4-(o-methoxyphenyl)-
BDBM50056039
NSC167758
AKOS040746572
BENZYL ALCOHOL, alpha-(3-(4-(o-METHOXYPHENYL)-1-PIPERAZINYL)PROPYL)-p-FLUORO-
NS00123097
Q27251767
1-(4-Fluoro-phenyl)-4-[4-(2-methoxy-phenyl)-piperazin-1-yl]-butan-1-ol
1-(4-Fluorophenyl)-4-[4-(2-methoxyphenyl)-1-piperazinyl]-1-butanol
(+/-)-.ALPHA.-(P-FLUOROPHENYL-4-(O-METHOXYPHENYL)-1-PIPERAZINEBUTANOL