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4'-Fluorocarbonyl)-N-(2-pyridyl)piperazine

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Identification
Molecular formula
C19H22FN3O
CAS number
91595-80-1
IUPAC name
1-(4-fluorophenyl)-4-[4-(2-pyridyl)piperazin-1-yl]butan-1-one
State
State

The compound is typically in a solid state at room temperature, specifically in the form of a powder or crystalline solid.

Melting point (Celsius)
82.50
Melting point (Kelvin)
355.65
Boiling point (Celsius)
453.20
Boiling point (Kelvin)
726.35
General information
Molecular weight
330.40g/mol
Molar mass
330.3870g/mol
Density
1.2487g/cm3
Appearence

4'-Fluorocarbonyl)-N-(2-pyridyl)piperazine is a white to off-white solid. It might appear as a crystalline powder depending on its preparation method and purity.

Comment on solubility

Solubility of 1-(4-fluorophenyl)-4-[4-(2-pyridyl)piperazin-1-yl]butan-1-one

The solubility of the compound 1-(4-fluorophenyl)-4-[4-(2-pyridyl)piperazin-1-yl]butan-1-one can be influenced by several key factors:

  • Polarity: The presence of both aromatic and heterocyclic groups may result in a moderately polar character, affecting its solubility in various solvents.
  • Solvent Effects: Typically, such compounds demonstrate varied solubility in:
    • Polar solvents: May exhibit reasonable solubility in alcohols or water, depending on specific functional groups.
    • Non-polar solvents: Might dissolve better in organic solvents like dichloromethane or ethyl acetate.
  • Temperature Dependence: Generally, solubility increases with temperature. It is advisable to conduct solubility tests at different temperatures to ascertain behavior.

In conclusion, better understanding the solubility characteristics of this compound can aid in various applications, ranging from formulation development to pharmacological activity assessments. Hence, conducting empirical solubility studies is encouraged to determine precise dissolution behavior, which can significantly impact its efficacy and usability.

Interesting facts

Interesting Facts about 1-(4-fluorophenyl)-4-[4-(2-pyridyl)piperazin-1-yl]butan-1-one

This compound, known for its complex structure, plays a significant role in medicinal chemistry, particularly in the development of potential pharmaceutical agents. Here are some intriguing insights about this compound:

  • Unique Structure: The compound features a distinct combination of a piperazine ring and a pyridine moiety, which are known to confer important biological properties.
  • Pharmacological Potential: Studies suggest that compounds with similar structural frameworks may exhibit antipsychotic, antidepressant, or anxiolytic effects, making this compound a subject of interest in neuroscience research.
  • Fluorine Substitution: The presence of the fluorine atom in the phenyl ring is known to enhance the lipophilicity and metabolic stability of compounds, which can lead to improved pharmacokinetic profiles.
  • Research Applications: This compound can serve as a versatile building block for the synthesis of even more complex molecules in drug discovery processes.
  • Interaction with Receptors: Due to its ability to interact with various neurotransmitter receptors, it may contribute to our understanding of receptor mechanisms and their role in mental health.

In conclusion, 1-(4-fluorophenyl)-4-[4-(2-pyridyl)piperazin-1-yl]butan-1-one represents a fascinating area of study that merges organic synthesis with pharmacology. The research surrounding such compounds is pivotal in forging new pathways for therapeutic development.

Synonyms
Azaperone
1649-18-9
Azaperon
Suicalm
Fluoperidol
Eucalmyl
Azeperone
Sedaperone vet
Azaperona
1-Butanone, 1-(4-fluorophenyl)-4-[4-(2-pyridinyl)-1-piperazinyl]-
Azaperonum
NSC 170976
R 1929
1-(3-(4-Fluorobenzoyl)propyl)-4-(2-pyridyl)piperazine
4'-Fluoro-4-(4-(2-pyridyl)-1-piperazinyl)butyrophenone
CCRIS 1586
Azaperonum [INN-Latin]
Azaperona [INN-Spanish]
Azaperone for veterinary use
EINECS 216-715-8
UNII-19BV78AK7W
NSC-170976
BRN 0565491
19BV78AK7W
DTXSID2045361
CHEBI:88301
1-(4-Fluorophenyl)-4-[4-(2-pyridinyl)-1-piperazinyl]-1-butanone
1-Butanone, 1-(4-fluorophenyl)-4-(4-(2-pyridinyl)-1-piperazinyl)-
DTXCID0025361
Azaperone [USAN:USP:INN:BAN]
1-(4-fluorophenyl)-4-(4-(pyridin-2-yl)piperazin-1-yl)butan-1-one
5-23-03-00041 (Beilstein Handbook Reference)
Butyrophenone, 4'-fluoro-4-[4-(2-pyridyl)-1-piperazinyl]-
Azaperonum (INN-Latin)
1-(4-Fluorophenyl)-4-(4-(2-pyridinyl)-1-piperazinyl)-1-butanone
Azaperona (INN-Spanish)
1-(4-fluorophenyl)-4-[4-(pyridin-2-yl)piperazin-1-yl]butan-1-one
BUTYROPHENONE, 4'-FLUORO-4-(4-(2-PYRIDYL)-1-PIPERAZINYL)-
AZAPERONE (MART.)
AZAPERONE [MART.]
AZAPERONE (USP-RS)
AZAPERONE [USP-RS]
AZAPERONE (USP IMPURITY)
AZAPERONE [USP IMPURITY]
4'-Fluoro-4-[4-(2-pyridyl)-1-piperazinyl]butyrophenone
AZAPERONE (USP MONOGRAPH)
AZAPERONE [USP MONOGRAPH]
Azaperone (USAN:USP:INN:BAN)
Stresnil Injection
216-715-8
Stresnil
R-1929
1-(4-fluorophenyl)-4-(4-pyridin-2-ylpiperazin-1-yl)butan-1-one
MLS003106751
CHEMBL340211
NSC170976
NCGC00016590-01
Azaperone 100 microg/mL in Acetonitrile
CAS-1649-18-9
C19H22FN3O
Azaperone (1.0 mg/mL in Methanol)
SMR001233462
SR-05000001712
Stresnil (TN)
Azaperone VETRANAL
MFCD00866692
Azaperone (Standard)
Azaperone (USP/INN)
AZAPERONE [INN]
AZAPERONE [MI]
AZAPERONE [USAN]
Prestwick0_001117
Prestwick1_001117
Prestwick2_001117
Prestwick3_001117
Spectrum2_001250
Spectrum3_001966
BSPBio_001254
BSPBio_003566
MLS002154163
SCHEMBL121134
SPECTRUM1505332
SPBio_001160
SPBio_003117
AZAPERONE [GREEN BOOK]
BPBio1_001379
HY-B1470R
KBio3_002914
Lamotrigine 5-N-?-D-Glucuronide
HMS1571O16
HMS1922D20
HMS2090K03
HMS2093D03
HMS2098O16
HMS2230C17
HMS3369I10
HMS3652D15
HMS3715O16
HMS3885F11
Pharmakon1600-01505332
1-(4-fluorophenyl)-4-[4-(2-pyridyl)piperazin-1-yl]butan-1-one
BCP12176
EX-A9409
HY-B1470
YWB02172
Tox21_110512
BBL011031
BDBM50036733
CCG-39158
NSC758969
PDSP1_000828
PDSP2_000815
s4219
STK802185
AKOS005622715
Tox21_110512_1
CS-5158
DB11376
FA18061
KS-5204
NSC-758969
NCGC00016590-02
NCGC00016590-03
NCGC00016590-04
NCGC00016590-06
NCGC00016590-08
NCGC00095171-01
NCGC00095171-02
NCGC00095171-03
SY067157
Azaperone 1000 microg/mL in Acetonitrile
SBI-0206748.P001
WLN: T6N DNTJ D3VR DF& A- BT6NJ
AB00514057
NS00000088
SW196387-3
Azaperone, VETRANAL(TM), analytical standard
C73189
D02620
AB00514057-06
AB00514057_07
L000791
Q4832244
SR-05000001712-1
SR-05000001712-3
BRD-K45861246-001-05-0
BRD-K45861246-001-08-4
BRD-K45861246-001-13-4
BRD-K45861246-001-14-2
BRD-K45861246-001-15-9
Azaperone, British Pharmacopoeia (BP) Reference Standard
{4'-Fluoro-4-[4-(2-pyridyl)-1-piperazinyl]butyrophenone}
4'-Fluoro-4-[4-(2-pyridinyl)-1-piperazinyl]butyrophenone
Azaperone, European Pharmacopoeia (EP) Reference Standard
1-(4-Fluorophenyl)-4-(4-pyridin-2-ylpiperazin-1-yl)butan-
Azaperone, United States Pharmacopeia (USP) Reference Standard
Butyrophenone, {4'-fluoro-4-[4-(2-pyridyl)-1-piperazinyl]-}
1-Butanone, {1-(4-fluorophenyl)-4-[4-(2-pyridinyl)-1-piperazinyl]-}
1-(4-Fluoro-phenyl)-4-(4-pyridin-2-yl-piperazin-1-yl)-butan-1-one(Azaperone)
1-(4-Fluorophenyl)-4-[4-(2-pyridinyl)-1-piperazinyl]-1-butanone;4'-Fluoro-4-[4-(2-pyridyl)-1-piperazinyl]butyrophenone;Fluoperidol