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4'-Fluorocyclohexylketone hydrochloride

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Identification
Molecular formula
C15H20ClFNO2
CAS number
314728-85-3
IUPAC name
1-(4-fluorophenyl)-4-(4-hydroxy-1-piperidyl)butan-1-one;hydrochloride
State
State

At room temperature, 4'-Fluorocyclohexylketone hydrochloride is typically a solid. The hydrochloride form aids in its stability and ability to be handled as a solid material.

Melting point (Celsius)
222.00
Melting point (Kelvin)
495.00
Boiling point (Celsius)
400.00
Boiling point (Kelvin)
673.00
General information
Molecular weight
303.79g/mol
Molar mass
303.7910g/mol
Density
1.2570g/cm3
Appearence

The compound appears as a white to off-white crystalline powder. Its crystalline nature is typical for many compounds that contain a hydrochloride salt, providing added stability and distinct physical properties.

Comment on solubility

Solubility of 1-(4-fluorophenyl)-4-(4-hydroxy-1-piperidyl)butan-1-one; hydrochloride

This compound, 1-(4-fluorophenyl)-4-(4-hydroxy-1-piperidyl)butan-1-one hydrochloride, exhibits interesting solubility characteristics that are critical for its application in various fields. Typically, salts formed with hydrochloric acid, such as this compound, tend to show improved water solubility compared to their free base counterparts.

Key points regarding the solubility of this compound include:

  • Soluble in Water: The hydrochloride form is generally soluble in water, making it easier to formulate for pharmaceutical applications.
  • Influence of pH: The solubility can be affected by the pH of the solution, as the ionization of the -NH group plays a significant role.
  • Organic Solvents: May exhibit varying degrees of solubility in organic solvents, often depending on the solvent polarity.
  • Temperature Effects: Higher temperatures can enhance solubility; thus, temperature control is important in laboratory settings.

To summarize, the solubility of 1-(4-fluorophenyl)-4-(4-hydroxy-1-piperidyl)butan-1-one hydrochloride is notably influenced by its ionic form, environmental conditions, and the presence of other solvents. As stated, "Solubility is the gateway to bioavailability," and understanding these factors can greatly enhance the efficacy of this compound in its intended uses.

Interesting facts

Interesting Facts about 1-(4-Fluorophenyl)-4-(4-hydroxy-1-piperidyl)butan-1-one; hydrochloride

This compound, commonly referred to in the context of medicinal chemistry, is notable for its complex structure that integrates both aromatic and alicyclic components. Here are some fascinating aspects of this molecule:

  • Pharmacological Relevance: As a derivative of piperidine, this compound is often studied for its potential therapeutic applications, particularly in the fields of neuroscience and psychiatry.
  • Fluorinated Aromatic Ring: The presence of the 4-fluorophenyl group can enhance the lipophilicity and metabolic stability of the compound, influencing its efficacy and bioavailability.
  • Hydroxy Group Influence: The 4-hydroxy group at the piperidine moiety may play a crucial role in interacting with biological targets, modifying receptor affinity and activity.
  • Chloride Salt Form: As a hydrochloride salt, this form is often preferred in pharmaceutical formulations due to its improved solubility and stability, facilitating easier absorption in biological systems.
  • Potential Research Areas: Ongoing research often focuses on the compound's impact on neurotransmitter systems, particularly those related to mood regulation, anxiety, and cognitive function.

As the scientific community continues to explore its properties, this compound represents a unique intersection of organic chemistry and pharmacology. The complexity of its structure enables a broader understanding of how slight modifications can lead to significant changes in biological activity.

In summary, 1-(4-fluorophenyl)-4-(4-hydroxy-1-piperidyl)butan-1-one; hydrochloride is not just a compound of interest but a potential key in unraveling new therapeutic pathways in medicine!

Synonyms
AL-499
BUTYROPHENONE, 4'-FLUORO-4-(4-HYDROXYPIPERIDINO)-, HYDROCHLORIDE
4-(4-Hydroxypiperidino)-4'-fluorobutyrophenone hydrochloride
3Q66C69AGM
DTXSID70173336
1-BUTANONE, 1-(4-FLUOROPHENYL)-4-(4-HYDROXY-1-PIPERIDINYL)-, HYDROCHLORIDE (1:1)
DTXCID6095827
RefChem:200020
19668-15-6
UNII-3Q66C69AGM
SCHEMBL30658979