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Fluorophenyl piperidine derivative

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Identification
Molecular formula
C21H25ClFNO2
CAS number
178475-82-6
IUPAC name
1-(4-fluorophenyl)-4-[4-hydroxy-4-(p-tolyl)piperidin-1-ium-1-yl]butan-1-one;chloride
State
State

The compound is generally in solid state at room temperature, appearing as a crystalline solid.

Melting point (Celsius)
125.00
Melting point (Kelvin)
398.00
Boiling point (Celsius)
300.00
Boiling point (Kelvin)
573.00
General information
Molecular weight
343.83g/mol
Molar mass
343.8290g/mol
Density
1.2000g/cm3
Appearence

This compound typically appears as a white to off-white crystalline solid. Its fine powdery texture allows for easy dissolution in various solvents suitable for analytical applications.

Comment on solubility

Solubility of 1-(4-fluorophenyl)-4-[4-hydroxy-4-(p-tolyl)piperidin-1-ium-1-yl]butan-1-one; chloride

The solubility of 1-(4-fluorophenyl)-4-[4-hydroxy-4-(p-tolyl)piperidin-1-ium-1-yl]butan-1-one; chloride is influenced by its unique molecular structure, which combines organic and ionic characteristics. Due to the presence of a quaternary ammonium moiety in its structure, this compound is likely to exhibit substantial solubility in polar solvents.

Key solubility characteristics:

  • Polar solvents: High solubility is expected in water and alcohols because of the ionic chloride group.
  • Non-polar solvents: Limited solubility may occur in organic non-polar solvents due to the polar nature of the molecule.
  • Temperature effects: Solubility can increase with temperature, which is a common behavior in many ionic compounds.

In summary, because of its ionic nature imparted by the chloride, the solubility of this compound can be described as moderate to high in polar environments, making it potentially useful in various applications where dissolution in water or other polar media is advantageous.

Interesting facts

Interesting Facts about 1-(4-Fluorophenyl)-4-[4-hydroxy-4-(p-tolyl)piperidin-1-ium-1-yl]butan-1-one;chloride

This compound, a member of the piperidine class, showcases remarkable diversity in its chemical properties and potential applications. Here are some key points to consider:

  • Pharmaceutical Relevance: Its structure suggests potential applications in the pharmaceutical industry, particularly in the development of drugs targeting neurological disorders, given the presence of the piperidine and hydroxy groups which are often found in active compounds.
  • Substituent Influence: The inclusion of 4-fluorophenyl and p-tolyl groups can significantly influence the compound's reactivity and biological activity. Fluorine substituents, for example, can enhance lipophilicity and metabolic stability.
  • Ionization Properties: The presence of the quaternary ammonium group (indicated by the "piperidin-1-ium" moiety) suggests that this compound behaves as a salt in solution, which may affect its solubility and interaction with biological membranes.
  • Synthesis Challenges: The synthesis of such complex compounds typically requires multiple steps and careful handling of reagents, making it a subject of interest in synthetic organic chemistry.
  • Research Potential: With ongoing research into new psychoactive substances, compounds like this one are of interest for their potential therapeutic effects and mechanisms of action in the brain.

As researchers continue to explore the full breadth of this compound's properties, it stands as a testament to the intricate relationships between molecular structure and biological function. The *multidisciplinary nature* of its study encapsulates the essence of modern chemistry, merging synthetic techniques with biological insights.

In summary, the compound 1-(4-fluorophenyl)-4-[4-hydroxy-4-(p-tolyl)piperidin-1-ium-1-yl]butan-1-one;chloride not only exemplifies the complexity of chemical synthesis but also emphasizes the importance of structural diversity in the quest for advanced therapeutic agents.

Synonyms
1-[3-(p-fluorobenzoyl)propyl]-4-hydroxy-4-(p-tolyl)piperidinium chloride
1-(4-fluorophenyl)-4-[4-hydroxy-4-(4-methylphenyl)piperidin-1-ium-1-yl]butan-1-one;chloride
1-(3-(p-Fluorobenzoyl)propyl)-4-hydroxy-4-(p-tolyl)piperidinium chloride
1-[3-(p-Fluorobenzoyl)propyl]-4-hydroxy-4-(p-tolyl)piperidinium chloride;1-[3-(p-Fluorobenzoyl)propyl]-4-hydroxy-4-(p-tolyl)piperidinium chloride
NS00081881