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4'-Fluorococaine

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Identification
Molecular formula
C21H24FNO2
CAS number
35572-78-2
IUPAC name
1-(4-fluorophenyl)-4-(4-hydroxy-4-phenyl-1-piperidyl)butan-1-one
State
State

At room temperature, 4'-Fluorococaine exists as a solid. It is a crystalline substance that can occasionally be seen as a powder, underlining its solid state characteristics.

Melting point (Celsius)
197.00
Melting point (Kelvin)
470.15
Boiling point (Celsius)
415.15
Boiling point (Kelvin)
688.30
General information
Molecular weight
317.36g/mol
Molar mass
317.3640g/mol
Density
1.1365g/cm3
Appearence

4'-Fluorococaine is typically observed as a solid crystalline powder. It may appear in various shades of white to off-white, depending on the purity and the specific synthesis method used. The structure consists of its characteristic aromatic ring and piperidyl groups.

Comment on solubility

Solubility of 1-(4-fluorophenyl)-4-(4-hydroxy-4-phenyl-1-piperidyl)butan-1-one

The solubility of 1-(4-fluorophenyl)-4-(4-hydroxy-4-phenyl-1-piperidyl)butan-1-one can be described as follows:

  • Polarity: Due to the presence of hydroxyl (-OH) groups and various aromatic structures, this compound exhibits polar characteristics, which generally enhance its solubility in polar solvents.
  • Solvent Interaction: It is likely to be soluble in solvents such as water and alcohols due to hydrogen bonding capabilities from the hydroxy group.
  • Temperature Dependency: Solubility may vary with temperature; typically, an increase in temperature can lead to greater solubility for many organic compounds.
  • pH Effects: The compound may demonstrate different solubility behaviors under varying pH conditions due to the ionization of the hydroxyl group, which might enhance solubility in basic solutions.

In summary, the solubility of this compound is influenced by its molecular structure, polarity, and the nature of the solvent used. As noted, "the combination of functional groups plays a crucial role in determining the overall solubility profile." Understanding these factors is essential for applications involving this compound.

Interesting facts

Interesting Facts about 1-(4-fluorophenyl)-4-(4-hydroxy-4-phenyl-1-piperidyl)butan-1-one

This compound, known for its complex structure, falls under the category of piperidine derivatives. Its significance in the field of medicinal chemistry is noteworthy due to its potential pharmacological applications. Here are some engaging insights:

  • Pharmacological Potential: Compounds like this piperidine derivative are often explored for their therapeutic capabilities, particularly in the treatment of various mental health disorders. The presence of a fluorine atom can enhance bioactivity.
  • Structure-Activity Relationship: The intricate design of 1-(4-fluorophenyl)-4-(4-hydroxy-4-phenyl-1-piperidyl)butan-1-one makes it an interesting subject for structure-activity relationship studies. Scientists aim to understand how modifications to the structure can improve effectiveness and reduce side effects.
  • Research Applications: Its unique chemical features allow it to serve as a suitable candidate for various experiments in drug development and testing. Researchers are keen on examining its interactions at molecular levels.
  • Production Techniques: The synthesis of this compound often involves advanced organic chemistry techniques, which highlight the importance of understanding synthetic pathways and the principles of chirality in pharmaceutical preparations.

As the field of chemistry continues to evolve, compounds such as 1-(4-fluorophenyl)-4-(4-hydroxy-4-phenyl-1-piperidyl)butan-1-one serve as a reminder of how intricate molecular designs can lead to significant advancements in therapeutic applications. The exploration of such compounds not only deepens our understanding of chemical interactions but also brings hope for future medicinal innovations.

Synonyms
Dechlorohaloperidol
3109-12-4
1-(4-fluorophenyl)-4-(4-hydroxy-4-phenylpiperidin-1-yl)butan-1-one
BRN 0316568
QKZ09O18R6
BUTYROPHENONE, 4'-FLUORO-4-(4-HYDROXY-4-PHENYLPIPERIDINO)-
UNII-QKZ09O18R6
DTXSID90953192
4-(4'-Phenyl-4'-hydroxypiperidino)-p-fluorobutyrophenone
HALOPERIDOL IMPURITY A [EP IMPURITY]
R-1838
4-21-00-00656 (Beilstein Handbook Reference)
1-Butanone, 1-(4-fluorophenyl)-4-(4-hydroxy-4-phenyl-1-piperidinyl)-
HALOPERIDOL IMPURITY A (EP IMPURITY)
DTXCID501381250
Dechloro Haloperidol
Dechloro Haloperidol (Haloperidol Impurity B)
CHEMBL54206
Deschlorohaloperidol
SCHEMBL8986042
BDBM50019949
FD158067
Q27287314
1-(4-Fluoro-phenyl)-4-(4-hydroxy-4-phenyl-piperidin-1-yl)-butan-1-one