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1-(4-fluorophenyl)-6-methoxy-2-phenyl-tetralin-1-ol

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Identification
Molecular formula
C22H21FO2
CAS number
154057-56-4
IUPAC name
1-(4-fluorophenyl)-6-methoxy-2-phenyl-tetralin-1-ol
State
State

At room temperature, 1-(4-Fluorophenyl)-6-methoxy-2-phenyl-tetralin-1-ol is typically found in a solid state.

Melting point (Celsius)
168.00
Melting point (Kelvin)
441.20
Boiling point (Celsius)
462.50
Boiling point (Kelvin)
735.70
General information
Molecular weight
320.37g/mol
Molar mass
320.3660g/mol
Density
1.2091g/cm3
Appearence

1-(4-Fluorophenyl)-6-methoxy-2-phenyl-tetralin-1-ol typically appears as a crystalline solid. The color can vary from white to off-white, depending on the presence of any impurities or synthesis method variations.

Comment on solubility

Solubility of 1-(4-Fluorophenyl)-6-methoxy-2-phenyl-tetralin-1-ol

The solubility of 1-(4-fluorophenyl)-6-methoxy-2-phenyl-tetralin-1-ol is an intriguing aspect that can significantly influence its application in various fields. Understanding its solubility in different solvents is crucial for both practical and theoretical considerations. Here are some key points about the solubility of this compound:

  • Polarity: Given the presence of a methoxy group and a hydroxyl group, the polarity of this compound is notably affected. Generally, compounds with polar functional groups tend to exhibit increased solubility in polar solvents, such as water.
  • Solvent Compatibility: Solubility can vary dramatically between solvents. Here are some potential solvent interactions:
    • Water: Limited solubility expected due to the hydrophobic nature of the phenyl groups.
    • Organic solvents: Better solubility likely in organic solvents such as ethanol, methanol, or dimethyl sulfoxide (DMSO).
  • Temperature Influence: The solubility may increase with temperature, which is a common trend for many organic compounds—higher thermal energy can aid in overcoming intermolecular forces.
  • pH Dependence: If the compound is dissolved in aqueous solutions, the pH level may alter its solubility through ionization of the hydroxyl group, consequently affecting its solubility profile.

In summary, while 1-(4-fluorophenyl)-6-methoxy-2-phenyl-tetralin-1-ol presents some challenges in achieving high solubility in water, it may show better solubility in organic solvents. This crucial knowledge aids in its utilization for synthesis and further research applications.

Interesting facts

Interesting Facts about 1-(4-fluorophenyl)-6-methoxy-2-phenyl-tetralin-1-ol

This intriguing compound, with its complex structure, offers a fascinating glimpse into the world of organic chemistry and pharmacology. It belongs to a class of chemical compounds known as tetralins, which are characterized by their bicyclic structure. Here are some notable points about this particular tetralin derivative:

  • Structural Diversity: The presence of a fluorine atom and methoxy group in its structure contributes to a unique set of properties. Fluorine’s electronegativity enhances biological activity, making this compound a potential candidate for medicinal research.
  • Pharmacological Potential: Compounds that share structural similarities with this tetralin derivative have been explored for their roles in various therapeutic areas including neuroprotection, anti-inflammatory, and antidepressant activities. Researchers are continuously investigating their mechanisms of action.
  • Synthetic Pathways: The synthesis of such compounds often involves multi-step reactions that can include Friedel-Crafts alkylation, nucleophilic substitution, and others. This highlights the creativity and innovation required in synthetic organic chemistry.
  • Role in Research: Compounds like this one are often used as lead compounds in drug discovery processes, allowing scientists to create and test variations to optimize for desired biological activity.
  • Intriguing Interactions: The interactions between various functional groups present in the compound could influence its binding affinity to biological targets, amplifying the interest among researchers to understand these interactions.

In summary, 1-(4-fluorophenyl)-6-methoxy-2-phenyl-tetralin-1-ol is not only a compound of significant interest due to its structural characteristics but also a promising subject for ongoing scientific inquiry. As the field of medicinal chemistry evolves, the exploration of such compounds will undoubtedly lead to breakthroughs in therapies for various health conditions.

Synonyms
4310-62-7
1,2,3,4-Tetrahydro-1-(p-fluorophenyl)-6-methoxy-2-phenyl-1-naphthol
1-NAPHTHOL, 1,2,3,4-TETRAHYDRO-1-(p-FLUOROPHENYL)-6-METHOXY-2-PHENYL-
BRN 2016145
1-(p-Fluorophenyl)-6-methoxy-2-phenyl-1,2,3,4-tetrahydro-1-naphthol
7MGG5ZC6LW
DTXSID40962895
1-(4-Fluorophenyl)-1,2,3,4-tetrahydro-6-methoxy-2-phenyl-1-naphthalenol
1-(4-Fluorophenyl)-6-methoxy-2-phenyl-1,2,3,4-tetrahydronaphthalen-1-ol
1-Naphthalenol, 1-(4-fluorophenyl)-1,2,3,4-tetrahydro-6-methoxy-2-phenyl-