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pF-159

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Identification
Molecular formula
C26H33FN2O2
CAS number
244824-61-3
IUPAC name
1-(4-fluorophenyl)-7-[4-(2-methoxyphenyl)piperazin-1-yl]heptan-1-one
State
State

At room temperature, pF-159 is a solid. It is stable under normal conditions and typically handled in powdered form for research and development activities.

Melting point (Celsius)
96.00
Melting point (Kelvin)
369.15
Boiling point (Celsius)
344.00
Boiling point (Kelvin)
617.15
General information
Molecular weight
436.57g/mol
Molar mass
436.5650g/mol
Density
1.1123g/cm3
Appearence

pF-159 appears as a white to off-white crystalline powder. The compound has a relatively consistent particle size and is typically odorless.

Comment on solubility

Solubility of 1-(4-fluorophenyl)-7-[4-(2-methoxyphenyl)piperazin-1-yl]heptan-1-one

The solubility of 1-(4-fluorophenyl)-7-[4-(2-methoxyphenyl)piperazin-1-yl]heptan-1-one is influenced by several factors, given its complex molecular structure. Understanding these factors can help predict its behavior in various solvents.

Key Factors Affecting Solubility:

  • Molecular Structure: The presence of bulky aromatic rings, such as 4-fluorophenyl and 2-methoxyphenyl, can hinder solubility in polar solvents.
  • Polarity: The methoxy group can enhance solubility in polar solvents due to its electronegative oxygen, which contributes to hydrogen bonding.
  • Hydrophobicity: The heptan-1-one chain may impart hydrophobic characteristics, decreasing solubility in water but potentially increasing it in organic solvents.

In summary, the solubility of this compound may vary significantly between solvents, presenting challenges and opportunities in formulation and application. A common observation in related compounds is that they tend to exhibit:

  1. Higher solubility in organic solvents (e.g., DMSO, ethanol)
  2. Limited solubility in aqueous solutions

Thus, evaluating specific solubility parameters through empirical testing remains essential to harness the full potential of 1-(4-fluorophenyl)-7-[4-(2-methoxyphenyl)piperazin-1-yl]heptan-1-one in practical applications.

Interesting facts

Interesting Facts about 1-(4-fluorophenyl)-7-[4-(2-methoxyphenyl)piperazin-1-yl]heptan-1-one

1-(4-fluorophenyl)-7-[4-(2-methoxyphenyl)piperazin-1-yl]heptan-1-one, often referred to in the scientific community for its complex structure, possesses several intriguing characteristics that are worthy of exploration. Below are some fascinating aspects:

  • Pharmacological Potential: This compound is being investigated for its potential therapeutic applications, particularly in the realm of neuropharmacology. Its structure suggests possible interactions with neurotransmitter systems, which is pivotal for drug development.
  • Fluorine as a Game-Changer: The presence of fluorine in the compound enhances its lipophilicity, which is often associated with improved bioavailability and altered metabolic pathways. Fluorinated compounds are renowned for their ability to increase the stability of drugs in the body.
  • Piperazine Ring Characteristics: The inclusion of a piperazine moiety not only contributes to the compound’s structural complexity but also imparts unique pharmacological properties. Compounds featuring piperazine derivatives are commonly studied for their effects on psychotropic states.
  • 2-Methoxyphenyl Substitution: The 2-methoxyphenyl group adds an interesting steric factor that may influence the compound's ability to cross the blood-brain barrier, which is critical for central nervous system activity.
  • Structure-Activity Relationship: The intricate design of this compound provides an excellent opportunity for researchers to explore structure-activity relationships (SARs), which is essential for optimizing the efficacy and safety profiles of novel pharmaceuticals.
  • Synthetic Challenges: The synthesis of such a complex organic molecule underscores the advancements in synthetic organic chemistry and poses challenges that encourage innovation in reaction conditions and mechanisms.

In conclusion, 1-(4-fluorophenyl)-7-[4-(2-methoxyphenyl)piperazin-1-yl]heptan-1-one is not just a chemical entity but a promising lead compound that may pave the way for new therapeutic strategies in treating various disorders. As research continues, its full potential is yet to be unveiled, making it a captivating subject for chemists and pharmacologists alike.

Synonyms
BRN 0715641
HEPTANOPHENONE, 4'-FLUORO-7-(4-(o-METHOXYPHENYL)-1-PIPERAZINYL)-
17160-74-6
4'-Fluoro-7-(4-(o-methoxyphenyl)-1-piperazinyl)heptanophenone
DTXSID30169139
DTXCID1091630