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4'-Fluoroacetophenone

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Identification
Molecular formula
C8H7FO
CAS number
403-42-9
IUPAC name
1-(4-fluorophenyl)ethanone
State
State

At room temperature, 4'-Fluoroacetophenone is in a liquid state.

Melting point (Celsius)
4.00
Melting point (Kelvin)
277.15
Boiling point (Celsius)
198.00
Boiling point (Kelvin)
471.15
General information
Molecular weight
138.14g/mol
Molar mass
138.1490g/mol
Density
1.1160g/cm3
Appearence

4'-Fluoroacetophenone is a colorless liquid with a distinctive aromatic, floral odor. It is typically clear and can be slightly oily in texture.

Comment on solubility

Solubility of 1-(4-fluorophenyl)ethanone

1-(4-fluorophenyl)ethanone, also known by its IUPAC name, showcases interesting solubility characteristics largely influenced by its molecular structure. Key aspects of its solubility include:

  • Solvent Affinity: This compound tends to be soluble in a variety of organic solvents, such as ethanol, ether, and chloroform. The presence of the fluorophenyl group enhances its interaction with non-polar solvents.
  • Water Insolubility: 1-(4-fluorophenyl)ethanone exhibits low solubility in water. This is primarily due to the hydrophobic nature of the aromatic system, making it less favorable for solvation by polar solvents.
  • Temperature Dependence: As with many organic compounds, solubility can be affected by temperature changes, often increasing with a rise in temperature.

Overall, the solubility of 1-(4-fluorophenyl)ethanone underlines the importance of its molecular interactions, highlighting how functional groups can dramatically influence the physicochemical properties of chemical compounds.

Interesting facts

Interesting Facts About 1-(4-Fluorophenyl)ethanone

1-(4-Fluorophenyl)ethanone, also known as 4-Fluoroacetophenone, is a fascinating compound that finds applications in various fields of chemistry and beyond. Here are some noteworthy aspects of this chemical:

  • Reactivity: This compound belongs to the class of ketones, which are characterized by the presence of a carbonyl group (C=O). Ketones can undergo a variety of reactions, making them versatile intermediates in organic synthesis.
  • Fluorine Substitution: The substitution of a fluorine atom in the phenyl ring not only enhances the compound's reactivity but can also influence its biological activity. Fluorinated compounds are often more lipophilic, which can improve their ability to penetrate biological membranes.
  • Industrial Applications: 4-Fluoroacetophenone is utilized in the pharmaceutical industry as a building block for the synthesis of various drugs, illustrating the significance of ketones in organic chemistry.
  • Research Significance: This compound is a subject of interest in chemical research due to its potential role in developing new materials and its efficacy in biological systems. Its properties can be explored for applications in medicinal chemistry and agrochemicals.
  • Toxicity Considerations: Like many organic compounds, handling 1-(4-fluorophenyl)ethanone requires caution. It is important to understand the potential hazards associated with its use, including the need for protective equipment when working in the laboratory.

In summary, 1-(4-fluorophenyl)ethanone is not just a simple ketone; it serves as a crucial player in the dynamic world of organic synthesis and pharmaceutical development. Its unique characteristics provide opportunities for innovative reactions and the synthesis of complex molecules. As we expand our knowledge of such compounds, we pave the way for advancements in science and technology.

Synonyms
4'-Fluoroacetophenone
403-42-9
1-(4-Fluorophenyl)ethanone
4-FLUOROACETOPHENONE
p-Fluoroacetophenone
1-(4-Fluorophenyl)Ethan-1-One
Ethanone, 1-(4-fluorophenyl)-
Acetophenone, 4'-fluoro-
1-acetyl-4-fluorobenzene
MFCD00000354
UNII-TVQ090602V
P-FLUOROHYPNONE
para-Fluoroacetophenone
TVQ090602V
EINECS 206-960-9
NSC 30635
NSC-30635
4-FLUOROPHENYLETHANAL
4-fluorophenyl methyl ketone
4-ACETYLPHENYL FLUORIDE
1-(4-fluoro-phenyl)-ethanone
CHEMBL257923
DTXSID0059952
ZDPAWHACYDRYIW-UHFFFAOYSA-
METHYL 4-FLUOROPHENYL KETONE
acetophenone, p-fluoro-
BROMPERIDOL DECANOATE IMPURITY L [EP IMPURITY]
HALOPERIDOL DECANOATE IMPURITY L [EP IMPURITY]
4 fluoroacetophenone
p-fluoro acetophenone
BROMPERIDOL DECANOATE IMPURITY L (EP IMPURITY)
HALOPERIDOL DECANOATE IMPURITY L (EP IMPURITY)
1-(4-fluorophenyl) ethanone
pFluoroacetophenone
4fluoroacetophenone
4-fluoracetophenone
1-(4-Fluorophenyl)ethanone; Haloperidol Decanoate Imp. L (EP); Haloperidol Decanoate Impurity L
NSC30635
4'-fluoracetophenone
4'-fluoroactophenone
4- fluoroacetophenone
4-fluoro acetophenone
4-fluoroaceto phenone
4' -fluoroacetophenone
4'-fluoro-acetophenone
Acetophenone, 4'fluoro
Pipamperone metabolite M-X
1-fluoro-4-acetyl-benzene
Ethanone, 1(4fluorophenyl)
SCHEMBL54677
1-(4'-fluorophenyl)ethanone
1-(4-fluorophenyl)-ethanone
4'-Fluoroacetophenone, 99%
1-(4-Fluorophenyl)ethanone #
Acetophenone, 4'fluoro (8CI)
DTXCID3039749
SCHEMBL13341603
Acetophenone, 4'-fluoro-(8CI)
HY-Y0779
BDBM50376210
STK328125
AKOS000119732
AC-3641
CS-W020117
FF37945
PS-9091
F0261
NS00043755
EN300-18001
D70558
4 inverted exclamation mark(R)-Fluoroacetophenone
1-(4-Fluorophenyl)ethanone; 4'-Fluoroacetophenone
Q27290448
Z57127466
F0001-1142