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Glimepiride

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Identification
Molecular formula
C24H34ClN3O5S
CAS number
93479-97-1
IUPAC name
1-(4-fluorophenyl)sulfonyl-3-sec-butyl-urea
State
State

At room temperature, Glimepiride is in a solid state, specifically as a crystalline powder. It is not volatile and is stable under normal conditions of use and storage.

Melting point (Celsius)
207.50
Melting point (Kelvin)
480.65
Boiling point (Celsius)
300.00
Boiling point (Kelvin)
573.15
General information
Molecular weight
490.62g/mol
Molar mass
490.6170g/mol
Density
1.5580g/cm3
Appearence

Glimepiride generally appears as a white to yellowish-white crystalline powder. It may have a slight odor. The powder is typically fine and can be mixed with other substances to form tablets for pharmaceutical use.

Comment on solubility

Solubility of 1-(4-fluorophenyl)sulfonyl-3-sec-butyl-urea

The solubility of 1-(4-fluorophenyl)sulfonyl-3-sec-butyl-urea can be influenced by several factors, including its molecular structure and the presence of functional groups. Typically, this compound features a sulfonyl group, which significantly impacts its solubility in various solvents.

  • Polar solvents: Compounds with sulfonyl groups tend to be more soluble in polar solvents due to the formation of hydrogen bonds.
  • Non-polar solvents: Conversely, the presence of the sec-butyl group may enhance solubility in non-polar solvents, although likely to a lesser degree.
  • Temperature effects: Solubility can also improve with temperature; as temperatures increase, solute-solvent interactions often become more favorable.
  • pH dependency: The solubility might vary with pH, especially if the compound can undergo protonation or deprotonation.

In general, one might expect moderate solubility in water and higher solubility in organic solvents like dimethyl sulfoxide (DMSO) or methanol. It’s important to conduct specific solubility tests to determine the exact solubility characteristics and behavior of this compound in different environments.

To summarize, the solubility of 1-(4-fluorophenyl)sulfonyl-3-sec-butyl-urea is determined not only by the inherent properties of the molecule but also by the solvent and conditions used during the assessment. Conducting experiments to understand these interactions will provide deeper insights into its solubility patterns.

Interesting facts

Interesting Facts about 1-(4-Fluorophenyl)sulfonyl-3-sec-butyl-urea

1-(4-Fluorophenyl)sulfonyl-3-sec-butyl-urea is a fascinating compound that has drawn attention in the fields of medicinal chemistry and pharmacology. This compound is notable for several reasons:

  • Pharmacological Potential: The unique structure of this compound suggests that it may have valuable applications in drug development, especially in designing new therapeutic agents.
  • Fluorination: The presence of a fluorine atom is critical because it often enhances the biological activity of organic molecules. Fluorinated compounds can lead to improved metabolic stability and bioavailability.
  • Urea Derivative: As a urea derivative, this compound can mimic natural substrates, which is essential in designing inhibitors for enzymes involved in various biochemical pathways.
  • Sulfonyl Group: The sulfonyl functional group can impart unique electronic and steric properties, influencing the binding interactions within biological systems.
  • Structure-Activity Relationships (SAR): Researchers analyze the relationship between the molecular structure and the biological activity of this compound to understand how modifications can lead to enhanced effects.

Researchers are continually exploring the properties and potential applications of compounds like 1-(4-fluorophenyl)sulfonyl-3-sec-butyl-urea as they hold promises in pharmaceutical innovations. The continuous study of such compounds is not only vital for advancing drug discovery but also for increasing our understanding of how molecular modifications affect biological behavior.

As one scientist highlighted, "The journey of discovering the potential of a compound like this is as exciting as it is complex, showcasing the elegance of chemistry in the realm of life sciences."

Synonyms
889-84-9
FVA53FG54W
N1-(p-Fluorobenzenesulfonyl)-N2-(1-methylpropyl)urea
Benzenesulfonamide, 4-fluoro-N-(((1-methylpropyl)amino)carbonyl)-
1-butan-2-yl-3-(4-fluorophenyl)sulfonylurea
N-(sec-Butylcarbamoyl)-4-fluorobenzenesulfonamide
UNII-FVA53FG54W
DTXSID601008566
UREA, 1-SEC-BUTYL-3-((P-FLUOROPHENYL)SULFONYL)-
N'-Butan-2-yl-N-(4-fluorobenzene-1-sulfonyl)carbamimidic acid