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Silodosin

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Identification
Molecular formula
C25H32ClNO4S
CAS number
160970-54-7
IUPAC name
1-(4-isopropylsulfonylphenyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-2-ium;chloride
State
State

Silodosin is typically found as a solid at room temperature.

Melting point (Celsius)
105.00
Melting point (Kelvin)
378.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
495.06g/mol
Molar mass
495.0160g/mol
Density
1.1800g/cm3
Appearence

Silodosin appears as a white to off-white crystalline powder.

Comment on solubility

Solubility of 1-(4-isopropylsulfonylphenyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-2-ium;chloride

The solubility of 1-(4-isopropylsulfonylphenyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-2-ium;chloride is a key characteristic that influences its applications in various fields. Understanding its solubility can aid in predicting its behavior in different environments. Here are some important points regarding its solubility:

  • Polarity: The presence of sulfonyl and an ammonium-like moiety suggests strong polar characteristics, which likely contributes to increased solubility in polar solvents.
  • Hydrochloride Form: As a chloride salt, it generally exhibits better solubility in water compared to its free base form.
  • Temperature Dependence: Solubility typically increases with temperature; thus, higher temperatures may enhance dissolution.
  • Solvent Interaction: This compound may show varying solubility in organic solvents such as methanol and ethanol, depending on the specific interactions between the solvent and the solute.
  • pH Sensitivity: Given its structure, the solubility might also be influenced by the pH of the solution, particularly if the compound could undergo protonation.

To summarize, the solubility of this compound is multifaceted and influenced by various factors such as polarity, the presence of chloride, temperature, solvent type, and pH conditions. Understanding these factors is essential for effectively utilizing this compound in practical applications.

Interesting facts

Exploring 1-(4-Isopropylsulfonylphenyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-2-ium;chloride

The compound 1-(4-isopropylsulfonylphenyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-2-ium; chloride is a fascinating example of a tetrahydroisoquinoline derivative, a category that has garnered attention in medicinal chemistry due to its diverse biological activities.

Key Characteristics

  • Pharmacological relevance: Compounds of this class have been investigated for their potential in treating various conditions, including neurological disorders and cognitive enhancement.
  • Structural features: The unique combination of a sulfonyl group and methoxy substituents allows for interactions that influence the compound's reactivity and biological activity, showcasing the intricacies of organic synthesis.
  • Research background: The tetrahydroisoquinoline scaffold is recognized in pharmacology for its significant role in alkaloid chemistry, which provides insights into natural product synthesis and its applications in drug design.

This compound's unique architecture not only provides an intriguing platform for research but also emphasizes the importance of careful molecular design in the quest for therapeutic agents. As noted by many researchers, "The beauty of chemistry lies in the interplay of structure and function." Therefore, exploring such compounds can unveil new pathways for innovative treatments.

Potential Applications

  • Developing novel analgesics and anti-inflammatory agents.
  • Contributing to the synthesis of compounds with cognitive-enhancing properties.
  • Investigating applications in psychiatric and neurodegenerative conditions.

As research continues to unfold, compounds like 1-(4-isopropylsulfonylphenyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-2-ium; chloride could play a pivotal role in the future landscape of pharmaceutical science.

Synonyms
20884-91-7
Isoquinoline, 1,2,3,4-tetrahydro-1-(p-(isopropylsulfonyl)phenyl)-6,7-dimethoxy-2-methyl-, hydrochloride
1,2,3,4-Tetrahydro-1-(p-(isopropylsulfonyl)phenyl)-6,7-dimethoxy-2-methyl-isoquinoline HCl
RefChem:349914