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Rolipram

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Identification
Molecular formula
C16H21NO4
CAS number
61413-54-5
IUPAC name
1-[4-methoxy-2-(2-morpholinoethoxy)phenyl]butan-1-one
State
State

At room temperature, rolipram is typically found in a solid powdered form. It is odorless and stable under standard laboratory conditions.

Melting point (Celsius)
72.00
Melting point (Kelvin)
345.20
Boiling point (Celsius)
443.30
Boiling point (Kelvin)
716.50
General information
Molecular weight
289.35g/mol
Molar mass
275.3610g/mol
Density
1.2000g/cm3
Appearence

Rolipram typically appears as a white to off-white crystalline powder.

Comment on solubility

Solubility of 1-[4-methoxy-2-(2-morpholinoethoxy)phenyl]butan-1-one

The solubility of 1-[4-methoxy-2-(2-morpholinoethoxy)phenyl]butan-1-one can be understood by considering its chemical structure and properties. This compound is characterized by:

  • Aromatic Character: The presence of an aromatic system generally enhances solubility in organic solvents.
  • Functional Groups: The methoxy group and morpholino ring contribute to the overall polarity, which may affect its solubility in polar solvents.
  • Chain Length: The butan-1-one structure provides hydrophobic characteristics that can influence solubility in non-polar solvents.

As a result, one might find that:

  1. The compound is likely soluble in organic solvents such as ethanol and dimethyl sulfoxide (DMSO).
  2. It may exhibit limited solubility in water due to its larger hydrophobic tail.
  3. Understanding the balance between hydrophilic and hydrophobic portions is key to predicting its solubility behavior.

In summary, while 1-[4-methoxy-2-(2-morpholinoethoxy)phenyl]butan-1-one demonstrates reasonable solubility in organic solvents, its solubility in aqueous solutions may be significantly lower, making it crucial to consider the solvent system when working with this compound.

Interesting facts

Interesting Facts about 1-[4-methoxy-2-(2-morpholinoethoxy)phenyl]butan-1-one

1-[4-methoxy-2-(2-morpholinoethoxy)phenyl]butan-1-one is a fascinating compound that bridges the realms of organic chemistry and medicinal applications. This compound has garnered attention due to its unique structural features and potential biological activity.

Key Characteristics:

  • Functional Groups: The molecule contains both a methoxy group and a morpholino group, which enhances its versatility and reactivity.
  • Pharmacological Interest: Given its structural components, this compound is of significant interest in pharmaceutical research, particularly in drug design targeting various biological pathways.
  • Structure-Activity Relationship (SAR): Researchers often explore the effects of different substituents on the aromatic ring, demonstrating how small changes can lead to vastly different biological outcomes.

The morpholino moiety in the compound is particularly intriguing, as morpholines have been linked to a variety of pharmacological activities including antitumor and antimicrobial effects. As noted by many scientists, "the structural sophistication of amine-containing compounds opens new avenues in medicinal chemistry."

Additionally, compounds like 1-[4-methoxy-2-(2-morpholinoethoxy)phenyl]butan-1-one are excellent candidates for developing new therapies due to:

  • Potential to undergo metabolic transformations in biological systems.
  • Possibility of altering lipophilicity, which affects drug absorption and distribution.
  • Ability to interact with diverse biological targets, making them suitable for further development.

In summary, 1-[4-methoxy-2-(2-morpholinoethoxy)phenyl]butan-1-one is not just a compound, but a **gateway** to explore the intersection of chemistry and health sciences, highlighting how organic synthesis contributes to advancements in pharmacology.