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1-[(4-methoxyphenoxy)methyl]-3,4-dihydroisoquinoline

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Identification
Molecular formula
C17H17NO2
CAS number
330981-73-8
IUPAC name
1-[(4-methoxyphenoxy)methyl]-3,4-dihydroisoquinoline
State
State

At room temperature, 1-[(4-methoxyphenoxy)methyl]-3,4-dihydroisoquinoline is typically in a solid state.

Melting point (Celsius)
78.50
Melting point (Kelvin)
351.65
Boiling point (Celsius)
370.00
Boiling point (Kelvin)
643.15
General information
Molecular weight
255.32g/mol
Molar mass
255.3010g/mol
Density
1.2203g/cm3
Appearence

The compound typically appears as a pale yellow to light brown solid. It exists in crystalline form and is relatively stable under normal conditions of use and storage.

Comment on solubility

Solubility of 1-[(4-methoxyphenoxy)methyl]-3,4-dihydroisoquinoline (C17H17NO2)

The solubility of 1-[(4-methoxyphenoxy)methyl]-3,4-dihydroisoquinoline is influenced by various factors including its structural properties and the presence of specific functional groups. This compound exhibits a moderate level of solubility in common organic solvents, which can be detailed as follows:

  • Polar Solvents: It shows limited solubility in water due to its hydrophobic isoquinoline moiety.
  • Non-Polar Solvents: Increased solubility is observed in solvents like ethanol and methanol, thanks to the presence of the methoxy group, which can interact favorably with the solvent.
  • Aromatic Compounds: Being aromatic in nature, it can dissolve well in aromatic hydrocarbons, allowing for better interactions.

As a general trend, compounds of this class can often be described in terms of their solubility as:

"Like dissolves like."

This principle indicates that the polarity of a solvent should match with the polarity of the solute for optimal solubility. Given the functional groups present in 1-[(4-methoxyphenoxy)methyl]-3,4-dihydroisoquinoline, it is important to consider the solvent choice carefully in any practical application or experimental setup. Overall, while solubility is moderate in various solvents, it is crucial for researchers to empirically determine solubility in specific conditions for best results.

Interesting facts

Exploring 1-[(4-methoxyphenoxy)methyl]-3,4-dihydroisoquinoline

1-[(4-methoxyphenoxy)methyl]-3,4-dihydroisoquinoline is a fascinating compound with a unique structure that brings together both aromatic and heterocyclic components. Here are some interesting facts about this compound:

  • Diverse Applications: This compound has garnered attention in the fields of pharmaceuticals and medicinal chemistry due to its potential therapeutic properties.
  • Isoquinoline Framework: The isoquinoline moiety is notable for its presence in numerous natural products and biologically active molecules, making its derivatives like this one significant in drug discovery.
  • Ester Bonding: The 4-methoxyphenoxy group introduces interesting steric and electronic effects, which can influence the reactivity and binding affinity of the compound in biological systems.
  • Synthetic Routes: The synthesis of this compound often involves methodologies that are featured in advanced organic chemistry, showcasing the creativity and complexity of synthetic strategies used by chemists.
  • Research Insights: Ongoing research aims to further understand its biological activities, leading to potential implications in the treatment of various diseases, particularly those involving neurological pathways.
  • Interdisciplinary Relevance: The study of this compound not only requires knowledge of organic chemistry but also insights from fields such as pharmacology, materials science, and molecular biology.

In summary, 1-[(4-methoxyphenoxy)methyl]-3,4-dihydroisoquinoline exemplifies how complex molecular architectures can lead to rich avenues for research and application, embodying the innovative spirit of modern chemistry.

Synonyms
MEMOTINE
Memotine [INN]
18429-69-1
UNII-42BHH3WP14
42BHH3WP14
DTXSID90171551
Isoquinoline, 3,4-dihydro-1-[(4-methoxyphenoxy)methyl]-
3,4-DIHYDRO-1-((P-METHOXYPHENOXY)METHYL)ISOQUINOLINE
ISOQUINOLINE, 3,4-DIHYDRO-1-((4-METHOXYPHENOXY)METHYL)-
DTXCID3094042
1-[(4-methoxyphenoxy)methyl]-3,4-dihydroisoquinoline
Memotina
CHEMBL2111034
Q27258528