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Loratadine

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Identification
Molecular formula
C22H24ClN3O
CAS number
93957-54-1
IUPAC name
1-(4-methoxyphenyl)-2-(4-methylpiperazin-1-ium-1-yl)imino-ethanone;chloride
State
State

At room temperature, loratadine is typically found as a solid. Due to its crystalline nature, it may be ground into a fine powder for medicinal use or for formulation into tablets or other solid dosage forms.

Melting point (Celsius)
135.00
Melting point (Kelvin)
408.15
Boiling point (Celsius)
284.00
Boiling point (Kelvin)
557.15
General information
Molecular weight
383.86g/mol
Molar mass
383.8560g/mol
Density
1.2000g/cm3
Appearence

Loratadine hydrochloride is a white to off-white crystalline powder. It may appear as a solid in powdered form and does not have any particular odor. The powder is soluble in water and will typically form a clear solution when dissolved.

Comment on solubility

Solubility of 1-(4-methoxyphenyl)-2-(4-methylpiperazin-1-ium-1-yl)imino-ethanone;chloride

The solubility of 1-(4-methoxyphenyl)-2-(4-methylpiperazin-1-ium-1-yl)imino-ethanone;chloride is influenced by its ionic nature and the presence of functional groups that can interact with solvents.

Factors Affecting Solubility:

  • Ionic Nature: The chloride ion increases the compound’s solubility in polar solvents like water due to ion-dipole interactions.
  • Functional Groups: The methoxy and piperazine moieties can participate in hydrogen bonding, enhancing interactions with polar solvents.
  • Temperature: As with many ionic compounds, solubility can increase with temperature, allowing more dissolution in aqueous solutions.
  • pH Levels: Being a salt, the solubility may vary with changes in pH, potentially altering the ionization state of the piperazine group.

In general, ionic compounds like this one demonstrate a tendency to be more soluble in polar solvents and less soluble in non-polar solvents. Therefore, it is anticipated that this compound exhibits good solubility in water and other polar aprotic solvents, making it suitable for various applications in chemical formulations.

Interesting facts

Interesting Facts about 1-(4-Methoxyphenyl)-2-(4-methylpiperazin-1-ium-1-yl)imino-ethanone; Chloride

This intriguing compound, which we can refer to as compound X for convenience, has garnered attention in both pharmaceutical research and organic chemistry due to its potential applications. Here are some compelling aspects of this compound:

  • Pharmacological Interest: The structure of compound X suggests possible activity in psychiatric and neurological disorders, particularly due to the presence of the piperazine moiety, which is commonly associated with a variety of pharmacological properties.
  • Synthetic Versatility: The synthetic pathway to produce compound X involves multi-step reactions that highlight the creativity in organic synthesis. This compound serves as an excellent example of how different functional groups can be combined to yield complex molecules.
  • Intermolecular Interactions: The presence of both methoxy and piperazinium groups in compound X allows for various intermolecular interactions, such as hydrogen bonding and dipole-dipole interactions. These can significantly influence its chemical reactivity and biological activity.
  • Research Applications: Being a subject of interest for drug design, compound X could potentially lead to the discovery of new therapeutic agents that may address unmet medical needs.
  • Safety and Toxicology: As with many synthetic compounds, understanding the safety profile and toxicological aspects of compound X is crucial for its advancement into therapeutic use, making research in these areas essential.

In conclusion, compound X is not just a simple molecular entity; it's a representation of the complex interplay of chemistry, pharmacology, and synthetic capability. As the research continues, this compound may contribute significantly to scientific advancements.